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A kind of norisopoldin chitosan microsphere and preparation method thereof

A technology of meisobolidine chitosan acetate and norisobolidine, which is applied in the direction of bone diseases, non-central analgesics, antipyretics, etc., can solve the problem of low bioavailability, and achieve the goal of reducing drug consumption. The effect of dosage, good application prospect and simple operation

Inactive Publication Date: 2018-02-27
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0005] The object of the present invention is to provide a kind of norisobolidine chitosan microsphere and preparation method thereof for the low bioavailability problem of norisobolidine

Method used

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  • A kind of norisopoldin chitosan microsphere and preparation method thereof
  • A kind of norisopoldin chitosan microsphere and preparation method thereof
  • A kind of norisopoldin chitosan microsphere and preparation method thereof

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Embodiment 1

[0029] Experimental raw materials:

[0030] Norisoboldine (provided by Shanghai Traditional Chinese Medicine Standardization Research Center, purity > 98%); chitosan (Shanghai Boao Biotechnology Co., Ltd., batch number 130204, deacetylation degree ≥ 90.0%, viscosity < 100cps); acetonitrile, Formic acid (Merck, chromatographically pure); acetic acid (Sinopharm Chemical Reagent Co., Ltd., analytically pure); liquid paraffin (Sinopharm Chemical Reagent Co., Ltd., analytically pure), ethyl acetate, petroleum ether (manufactured by Tianjin Hengxing Chemical Reagent Co., Ltd. Co., Ltd., analytically pure); Span-80, Tween-20, Tween-80 (Sinopharm Chemical Reagent Co., Ltd., chemically pure); glutaraldehyde (Aladdin Industrial Company, with a mass fraction of 50%, chemically pure ); water is ultrapure water.

[0031] Main instruments:

[0032] Waters Alliance high performance liquid chromatograph; Waters 2998 PAD detector; H7650 transmission electron microscope (TEM) from HITACH comp...

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Abstract

The invention belongs to the field of preparation of chitosan microspheres, in particular to a norisoboldine chitosan microsphere and a preparation method thereof. Specifically, it includes the following steps: 1) first dissolving norisoboldine in acetic acid solution, then adding chitosan to swell and then ultrasonically degassing, to prepare norisoboldine chitosan acetic acid solution; 2) in the round bottom Add liquid paraffin and emulsifier to the flask, add the norisoboldine chitosan acetic acid solution prepared in step 1) dropwise with stirring, and stir and emulsify at 40 °C for 0.5 h; 3) add crosslinking agent dropwise to prepare Get norisoboldine chitosan microspheres. Norisoboldine is prepared into chitosan microspheres, and the encapsulation rate of norisoboldine reaches 69.27%, which can improve the bioavailability of norisoboldine in vivo and reduce the frequency of clinical administration. Reduce dosage and reduce adverse reactions. The preparation method of the norisoboldine chitosan microspheres is simple in operation, easy to repeat, and has good controllability, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of chitosan microspheres, and in particular relates to a norisopoldin chitosan microsphere and a preparation method thereof. Background technique [0002] Norisoboldine is a herbaceous herbaceous plant from the lauraceae Lindera aggregate (Sims) Kosterm. isolated from dry tubers, content up to 1%. In recent years, research on the anti-inflammatory and analgesic effects of black medicine found that total alkaloids of black medicine can significantly inhibit secondary paw swelling in rats with adjuvant arthritis, and also have a tendency to inhibit primary paw swelling. At the same time, the total alkaloids of black medicine can also reduce the severity of collagen arthritis in mice, reduce anti-collagen antibodies in serum, and protect bone and joint damage. The mechanism of action is to prevent the activation of NF-κB in RAW264.7 cells induced by lipopolysaccharide. And MAPKs phosphorylation and play ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/473A61K47/36A61P19/02A61P29/00
Inventor 陈建忠侴桂新李彧
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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