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Porous calcium phosphate microsphere material with surface big holes and preparation method and application of porous calcium phosphate microsphere material

A technology of porous calcium phosphate and calcium phosphate bone, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulations, medical science, etc. It can solve the problems of unfavorable growth of blood vessels and bone tissue, failure to match the growth rate of new bone, slow degradation rate, etc. problems, to achieve the effect of diversification of functions, realization of drug loading, and promotion of degradation speed

Active Publication Date: 2015-11-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a bone repair filling material, although calcium phosphate bone cement microspheres are rich in micropores, they lack macropores and poor connectivity between pores, which is not conducive to the growth of blood vessels and bone tissue into the material; in addition, its degradation rate is slow and cannot Matches the growth rate of new bone

Method used

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  • Porous calcium phosphate microsphere material with surface big holes and preparation method and application of porous calcium phosphate microsphere material
  • Porous calcium phosphate microsphere material with surface big holes and preparation method and application of porous calcium phosphate microsphere material

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Embodiment 1

[0033] Using gelatin as polysaccharide glue, modified starch as thickener, and "calcium dihydrogen phosphate-α-tricalcium phosphate-calcium carbonate" system bone cement to prepare porous calcium phosphate microspheres with large surface pores include:

[0034] (1) Dissolving gelatin at a ratio of 6g / 100mL in deionized water at 30°C to prepare a gelatin solution with a concentration of 6% (w / v);

[0035] (2) Dissolve the modified starch at a ratio of 2g / 100mL in deionized water at 25°C to prepare a modified starch solution with a concentration of 2% (w / v);

[0036] (3) Mix the gelatin solution obtained in step (1) with the modified starch solution obtained in step (2) to obtain a gelatin / modified starch mixed solution as "calcium dihydrogen phosphate-α-tricalcium phosphate-calcium carbonate" The liquid phase of the systemic bone cement;

[0037] (4) Mix the gelatin / modified starch mixed solution obtained in step (3) with the "calcium dihydrogen phosphate-α-tricalcium phosphat...

Embodiment 2

[0042] Using modified starch as polysaccharide glue, sodium alginate as thickener, and "tetracalcium phosphate-β-tricalcium phosphate-calcium dihydrogen phosphate" system bone cement to prepare porous calcium phosphate microspheres with large surface pores include:

[0043] (1) dissolving the modified starch at a ratio of 12g / 100mL in deionized water at 35°C to prepare a modified starch solution with a concentration of 12% (w / v);

[0044] (2) Sodium alginate was dissolved in 30°C deionized water at a ratio of 2g / 100mL to prepare a sodium alginate solution with a concentration of 2% (w / v);

[0045] (3) Mix the modified starch solution obtained in step (1) with the sodium alginate solution obtained in step (2) to obtain a modified starch / sodium alginate mixed solution as "tetracalcium phosphate-β-tricalcium phosphate-dicalcium phosphate The liquid phase of bone cement in hydrogen calcium” system;

[0046] (4) The modified starch / sodium alginate mixed solution obtained in step (...

Embodiment 3

[0051] The steps of preparing porous calcium phosphate microspheres with large surface pores by using xanthan gum as polysaccharide gum, hydroxypropyl cellulose sodium as thickener, and "partially crystalline calcium phosphate-calcium hydrogen phosphate" system bone cement include:

[0052] (1) dissolving xanthan gum in a ratio of 8g / 100mL in 40°C deionized water to make a xanthan gum solution with a concentration of 8% (w / v);

[0053] (2) Sodium hydroxypropyl cellulose was dissolved in 60°C deionized water at a ratio of 4g / 100mL to make a sodium hydroxypropyl cellulose solution with a concentration of 4% (w / v);

[0054] (3) The xanthan gum solution obtained in step (1) is mixed with the sodium hydroxypropyl cellulose solution obtained in step (2) to obtain a mixed solution of xanthan gum / sodium hydroxypropyl cellulose, which is used as "partial crystalline calcium phosphate" - the liquid phase of the bone cement of the "calcium hydrogen phosphate" system;

[0055] (4) Fully ...

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Abstract

The invention discloses a preparation method of a porous calcium phosphate microsphere material with surface big holes. The method includes the following steps of firstly, dissolving polysaccharide gum in deionized water to prepare a polysaccharide gum solution; secondly, dissolving a thickener in deionized water to prepare a thickener solution; thirdly, mixing the polysaccharide gum solution with the thickener solution to obtain a polysaccharide gum / thickener solution; fourthly, mixing calcium phosphate bone cement powder with the polysaccharide gum / thickener solution to obtain calcium phosphate bone cement slurry; fifthly, stirring the calcium phosphate bone cement slurry at a high speed, conducting ultrasonic treatment, dropwise adding the slurry to liquid nitrogen, and conducting curing and vacuum drying on refrigerated microspheres to obtain porous calcium phosphate microspheres with the surface big holes. The invention further discloses the porous calcium phosphate microsphere material with the surface big holes and application of the porous calcium phosphate microsphere material. The porous calcium phosphate microsphere material is provided with the surface big holes and has high porosity, pore connectivity and disintegration resistance.

Description

technical field [0001] The invention relates to the medical field of bone defect repair, in particular to a porous calcium phosphate microsphere material with large surface pores, a preparation method and an application. Background technique [0002] The artificial bone materials clinically used to replace bone defects are mainly calcium phosphate materials, including hydroxyapatite ceramics, β-tricalcium phosphate ceramics, biphasic calcium phosphate, calcium phosphate bone cement, bioactive glass and various calcium phosphate-based materials. composite material. Generally speaking, the application forms of calcium phosphate materials in the field of bone repair are mainly divided into dense and porous types according to their structure. The low porosity of dense bone repair materials is not conducive to tissue and cell ingrowth and angiogenesis, which affects the biological properties of the material. The interconnected pores in the material can provide channels for bloo...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56A61K47/04A61K9/16
CPCA61K9/16A61L27/12A61L27/56
Inventor 叶建东李海燕李继彦
Owner SOUTH CHINA UNIV OF TECH
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