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Method and process for synthesizing riboflavin sodium phosphate

A technology for riboflavin sodium phosphate and synthesis process, which is applied to the synthesis process of riboflavin sodium phosphate and the field of producing pharmaceutical products, can solve problems such as difficulties, and achieve the effects of low cost, easy control and high yield

Inactive Publication Date: 2016-01-27
天津盛丰源机械设备有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

The process seems very simple, but because only 5'-FMN has physiological activity in the phosphorylation reaction product of riboflavin, it is difficult to carry out the reaction selectively

Method used

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  • Method and process for synthesizing riboflavin sodium phosphate

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Experimental program
Comparison scheme
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Embodiment

[0016] 1. Add acetonitrile, pyridine, phosphorus oxychloride and riboflavin to the reaction kettle, then add water (1h), and keep at 15°C for 16h.

[0017] 2. Filtrate, filter with a metal rod microporous filter for 3 hours, and beat the filtrate to the hydrolysis tank.

[0018] 3. Hydrolysis, add hydrochloric acid (9%) to acidify in the hydrolysis tank, react at 50°C for 6h, add sodium hydroxide (25%) to adjust the pH to about 9, and cool down to 40°C, react for 12h.

[0019] 4. Filter, filter with a metal rod microporous filter for 3 hours, and put the filter cake into the crystallization tank.

[0020] 5. For crystallization, add hydrochloric acid (30%) to the crystallization tank to neutralize excess sodium hydroxide, adjust the pH to 5.5, and let cool to 5°C. Keep for 10h.

[0021] 6. Filtrate, filter with a centrifuge for 1.5 hours, add the wet filter cake into the beating tank, beat with ethanol water, stir for one hour, and then filter for 1.5 hours.

[0022] 7. Dry...

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Abstract

The invention relates to a method for producing a medical product, in particular to a process for synthesizing riboflavin sodium phosphate and belongs to the technical field of medicinal chemistry. The process mainly comprises the following steps that riboflavin and phosphorus oxychloride are subjected to an esterification reaction under certain conditions to generate riboflavin phosphate; the riboflavin phosphate is filtered to remove solid materials; the filtrate is hydrolyzed to generate the crude product of riboflavin sodium phosphate; the crude product of riboflavin sodium phosphate is filtered; the filter cakes are collected and crystallized to generate riboflavin sodium phosphate crystals; the riboflavin sodium phosphate crystals are filtered; the filter cakes are dried in a drier to obtain the product. The method is available in raw materials, low in cost, simple in reaction, easy to control and high in yield, and can be applied to batch production in workshops. The method has a wide application prospect in the aspect of synthesizing process of the riboflavin sodium phosphate.

Description

technical field [0001] The invention relates to a production of pharmaceutical products, in particular to a synthesis process of riboflavin sodium phosphate, which belongs to the technical field of medicinal chemistry. Background technique [0002] Riboflavin sodium phosphate is an anti-inflammatory drug, suitable for the treatment of angular cheilitis, cheilitis, glossitis, meningitis and scrotitis caused by riboflavin deficiency. It can also be used in the prevention and treatment of cardiovascular diseases, iron-deficiency anemia, and malignant tumors of the esophagus system, and can also be used as a food nutrition enhancer in large quantities. At present, the chemical synthesis route of riboflavin sodium phosphate can be divided into two kinds: the production technology of riboflavin 5'-sodium phosphate at home and abroad all adopts chemical synthesis method, and its synthetic route mainly contains two: one is in organic solvent , using riboflavin and partially hydroly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6561
Inventor 王娜
Owner 天津盛丰源机械设备有限公司
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