Degradable scaffold medical film preparation method

A kind of equipment, polylactic acid technology, applied in medical science, textiles and papermaking, non-woven fabrics, etc., can solve problems such as spinning difficulties, poor degradation controllability, slow degradation rate, etc., to achieve tissue regeneration, absorption, Simple operation effect

A kind of equipment, polylactic acid technology, applied in medical science, textiles and papermaking, non-woven fabrics, etc., can solve problems such as spinning difficulties, poor degradation controllability, slow degradation rate, etc., to achieve tissue regeneration, absorption, Simple operation effect

CN105396181AInactive Publication Date: 2016-03-16WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Degradable scaffold medical film preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of polymer electrospinning solution: Dissolve polylactic acid (PLLA) material in ethyl acetate, put the prepared mixture on a magnetic stirrer for stirring (stirring time is 6 hours), stir and disperse evenly. The proportioning concentration of the electrospinning solution is 8%;

[0023] (2) Electrospinning process: put the solution obtained in step (1) in the feeding injector of the spinning equipment, the injection volume is 10ml / h, the high voltage power supply is 20kv, the injector and the rotating drum receiving device The receiving is 18cm; Finally, the mesh support medical film is obtained on the receiving drum;

[0024] (3) Removal of organic solvents: put the medical film prepared in step (2) in a vacuum drying oven, adjust the temperature to 50°, and the drying cycle to 6 hours. Until the residual organic solvent is less than the national standard.

Embodiment 2

[0026] (1) Preparation of polymer electrospinning solution: Dissolve polylactic acid (PLLA) material in the co-solution of ethyl acetate and DMF (1:1), and put the prepared mixture on a magnetic stirrer for stirring (stirring time is 6 hours), stir to disperse evenly. The proportioning concentration of the electrospinning solution is 10%;

[0027] (2) Electrospinning process: place the solution obtained in step (1) in the feeding injector of the spinning equipment, the injection volume is 9ml / h, the high voltage power supply is 20kv, the injector and the rotating drum receiving device The receiving is 20cm; Finally, the mesh support medical film is obtained on the receiving drum;

[0028] (3) Removal of organic solvents: put the medical film prepared in step (2) in a vacuum drying oven, adjust the temperature to 55°, and the drying cycle to 8 hours. Until the residual organic solvent is less than the national standard.

Embodiment 3

[0030] (1) Preparation of polymer electrospinning solution: Dissolve polylactic acid (PLLA) material in ethyl acetate and tetrahydrofuran (1:1), and stir the prepared mixture on a magnetic stirrer (stirring time is 5 hours ), and stir to disperse evenly. The proportioning concentration of the electrospinning solution is 12%;

[0031] (2) Electrospinning process: put the solution obtained in step (1) in the feeding injector of the spinning equipment, the injection volume is 11ml / h, the high voltage power supply is 20kv, the injector and the rotating drum receiving device The receiving is 20cm; Finally, the mesh support medical film is obtained on the receiving drum;

[0032] (3) Removal of organic solvents: put the medical film prepared in step (2) in a vacuum drying oven, adjust the temperature to 45°, and the drying cycle to 6 hours. Until the residual organic solvent is less than the national standard.

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Abstract

The present invention discloses a degradable scaffold medical film preparation method, wherein electrostatic spinning equipment is used and appropriate process parameters are selected to prepare and mold the medical film having a mesh scaffold structure. According to the present invention, polylactic acid is adopted as a raw material and is dissolved in one or two organic solvents selected from ethyl acetate, tetrahydrofuran, dimethylformamide, chloroform and the like according to different ratios to prepare a spinning solution, and an electrostatic spinning method is used to prepare the degradable scaffold medical film; the prepared product has characteristics of physical isolation property, flexibility, degradability and selective permeation property, wherein the film can be well attached on the wound surface tissue through the physical isolation property and the flexibility so as to provide the tissue adhesion prevention effect, the re-operation pain on the patient can be reduced through the degradability, the transmission functions of blood, nutrition substances and growth factors in vivo can be effectively promoted through the selective permeation property, and the wound surface tissue cell proliferation and the rapid wound surface healing are easily achieved through the scaffold structure; and the operation of the method is simple, the practicality is strong, the stability of the product is high, and the product has large application space in the medicine field.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of a degradable stent medical film. Background technique [0002] According to reports, 90% of surgical procedures will lead to different degrees of adhesions. The sequelae of postoperative tissue adhesions are: persistent pain at the surgical site, postoperative adhesions, partial loss of function, and increased difficulty in reoperation and the potential for complications. In surgery, products to prevent postoperative adhesions are still in urgent need of the market. The anti-adhesion film is usually a comfortable semi-permeable film with good waterproof, anti-bacterial, breathable, physical isolation and other characteristics. At present, there are many kinds of materials used to prepare surgical medical membranes in clinical practice, such as sodium hyaluronate, chitosan, polyethylene glycol, etc., but the above-mentioned materials not only ha...

Claims

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Application Information

Patent Timeline
16 Mar 2016
Publication
CN105396181A
IPC
A61L31/06; A61L31/14; D04H1/728; D04H1/435
Inventors
许世生; 唐小雄