Degradable scaffold medical film preparation method

Abstract

The present invention discloses a degradable scaffold medical film preparation method, wherein electrostatic spinning equipment is used and appropriate process parameters are selected to prepare and mold the medical film having a mesh scaffold structure. According to the present invention, polylactic acid is adopted as a raw material and is dissolved in one or two organic solvents selected from ethyl acetate, tetrahydrofuran, dimethylformamide, chloroform and the like according to different ratios to prepare a spinning solution, and an electrostatic spinning method is used to prepare the degradable scaffold medical film; the prepared product has characteristics of physical isolation property, flexibility, degradability and selective permeation property, wherein the film can be well attached on the wound surface tissue through the physical isolation property and the flexibility so as to provide the tissue adhesion prevention effect, the re-operation pain on the patient can be reduced through the degradability, the transmission functions of blood, nutrition substances and growth factors in vivo can be effectively promoted through the selective permeation property, and the wound surface tissue cell proliferation and the rapid wound surface healing are easily achieved through the scaffold structure; and the operation of the method is simple, the practicality is strong, the stability of the product is high, and the product has large application space in the medicine field.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of a degradable stent medical film. Background technique [0002] According to reports, 90% of surgical procedures will lead to different degrees of adhesions. The sequelae of postoperative tissue adhesions are: persistent pain at the surgical site, postoperative adhesions, partial loss of function, and increased difficulty in reoperation and the potential for complications. In surgery, products to prevent postoperative adhesions are still in urgent need of the market. The anti-adhesion film is usually a comfortable semi-permeable film with good waterproof, anti-bacterial, breathable, physical isolation and other characteristics. At present, there are many kinds of materials used to prepare surgical medical membranes in clinical practice, such as sodium hyaluronate, chitosan, polyethylene glycol, etc., but the above-mentioned materials not only ha...

AI Technical Summary

Problems solved by technology

At present, there are many kinds of materials used to prepare surgical medical membranes in clinical practice, such as sodium hyaluronate, chitosan, polyethylene glycol, etc., but the above-mentioned materials not only have limited flexibility, but also have poor degradation controllability. conducive to practical application

Absorbable polylactic acid solid materials with a certain strength and shape are usually used abroad to achieve the purpose of isolating wounds and reducing adhesions, but due to their high strength and rigidity, poor flexibility and impact resistance, their clinical use effect is not good. not ideal

International patent WO2006 / 100895 discloses a medical film composed of lactide and caprolactone copolymer, which has good flexibility and strength, but the degradation rate of the material itself is relatively slow, and it takes 6 months for complete absorption, which may affect Wound healing and tissue repair function

Publication Nos. CN1241442A and CN1305928C Chinese patent documents respectively make polyglycolic acid and polylactic acid copolymers, polyethylene glycol and polylactic acid blends into surgical medical films, although the introduction of polyglycolic acid and polyethylene glycol can Accelerate the degradation rate of polylactic acid in vivo, but the purity of the film is not high and has no anti-inflammatory effect, which limits its wide application in the clinical medical field

The publication number is CN104056297A. The Chinese patent application discloses a polylactic acid-based composite material surgical medical membrane and its preparation method. However, the composite material is ibuprofen, although antibiotics can play anti-inflammatory and antibacterial effects, but it is difficult to spin and the quality is stable. Insufficient performance, it is difficult to realize industrial production

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