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Method for improving anaerobic fermentation efficiency of antibiotic drug residues containing sporophore

A technology of antibiotic dregs and anaerobic fermentation, which is applied in the direction of fermentation and fungi, and can solve the problems of low organic load of anaerobic fermentation of cephalosporin dregs, mismatch between processing capacity and output, and inability to meet processing requirements, etc. Achieve the effects of shortening the processing time, increasing the biogas production, and simple implementation

Active Publication Date: 2016-03-16
BIOLOGY INST OF HEBEI ACAD OF SCI
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  • Application Information

AI Technical Summary

Problems solved by technology

Although some pharmaceutical companies took the lead in carrying out anaerobic fermentation treatment of dregs and achieved initial results, there are still many problems. One of the key problems is that the main component of dregs of cephalosporins is not mycelium, but fungal differentiation. Sporozoites are extremely difficult to break the wall, resulting in low organic load of anaerobic fermentation of cephalosporin dregs, unstable system operation, serious mismatch between processing capacity and production volume, far from meeting processing needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Biogas production test by anaerobic fermentation: using 250mL anaerobic bottle, fully mixed anaerobic fermentation process, with 2 treatments:

[0018] Treatment 1: Cephalosporin C dregs were used as raw materials without any treatment, as a control;

[0019] Treatment 2: Use cephalosporin C dregs cultivated for 10 hours as raw material (the culture medium is 0.3% glucose aqueous solution, pH value 7.0-7.2, the amount of dregs added is 50% (v / v), and the culture temperature is 35± 2°C).

[0020] The organic load TS is 2%, (TS is also called the dry matter concentration, which refers to placing a certain amount of fermentation feed liquid in an oven at 100-105 °C and drying it to a constant weight, and the percentage of the dried material to the total weight), with normal The biogas slurry in the fermentation biogas digester is the inoculum, the inoculum amount is 20-30% (volume ratio), the fermentation temperature: medium temperature (35±2) ℃, the fermentation time is ...

Embodiment 2

[0024] Biogas production test by anaerobic fermentation: using 250mL anaerobic bottle, fully mixed anaerobic fermentation process, with 6 treatments,

[0025] Treatment 1: use cephalosporin C dregs as raw material, without any treatment, as a control;

[0026] Treatment 2: Use cephalosporin C dregs cultivated for 8 hours as raw material (the culture medium is 0.5% glucose aqueous solution, pH value 7.0-7.2, the amount of dregs added is 60% (v / v), and the culture temperature is 27± 2°C);

[0027] Treatment 3: Ultrasonic treatment of medicinal residues for 30 minutes (ultrasonic sound density: 0.6W / mL);

[0028] Treatment 4: ultrasonically treat the dregs cultivated in Treatment 2 for 30 minutes;

[0029] Treatment 5: Microwave treatment of medicinal residues for 2 minutes (power: 575W);

[0030] Treatment 6: Microwave the medicinal residues cultured in Treatment 2 for 2 minutes.

[0031] The organic load TS is 3%, (TS is also called the dry matter concentration, which refer...

Embodiment 3-7

[0036] Biogas production test by anaerobic fermentation: use 250mL anaerobic bottle, fully mixed anaerobic fermentation process, culture temperature of cephalosporin C dregs at 30±2°C, use biogas slurry in normal fermentation digester as inoculum, inoculum size 20 -30% (volume ratio), fermentation temperature 25-35°C, fermentation time 50d, each treatment was used as 5 parallels. The results are shown in Table 3. Anaerobic fermentation was performed on the cultivated cephalosporin C dregs, and the biogas production rate was significantly higher than that of the control. There was no significant difference in the average methane content of different treatments.

[0037] Table 3 Example 3-7 Biogas Production Situation

[0038] .

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Abstract

The invention discloses a method for improving anaerobic fermentation efficiency of antibiotic drug residues containing sporophore. The method includes the step of anaerobic fermentation, and the step of culturing the antibiotic drug residues containing sporophore is further included before the step of anaerobic fermentation. Taking cephalosporin C drug residues for example, after the culture step is added, the yield of marsh gas is raised by 50% or more; the method can be further combined with ultrasound, microwave, thermokalite and the like for pretreatment, and the yield of marsh gas is also raised by 50% or more. By means of the method, the problems of recycling of a great number of antibiotic drug residues and environmental pollution can be solved, and the method has great significance in promoting sustainable development of the antibiotics pharmaceutical industry and protecting the ecological environment and has actual economic and social benefits and wide application prospect.

Description

technical field [0001] The invention relates to the technical field of biogas resource treatment of antibiotic dregs, in particular to a method for improving the anaerobic fermentation efficiency of sporophyte-containing antibiotic dregs, especially cephalosporin C dregs. Background technique [0002] my country is the world's largest producer and exporter of antibiotic raw materials. The production of 1 ton of antibiotics produces about 8 to 10 tons of wet fungal residues. Therefore, the annual discharge of antibiotic residues reaches millions of tons. The residual culture medium and antibiotics in antibiotic residues The parent body and its degradation products are potentially harmful to the ecological environment and human health. The country has clearly listed antibiotic dregs as hazardous waste and prohibited them from being used in feed and fertilizer. The disposal method approved by the current policy is mainly incineration, and the incineration of 1 ton of medicinal r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P35/06
Inventor 程辉彩习彦花张丽萍王慧何强王宏伟崔冠慧张根伟尹淑丽刘洪伟
Owner BIOLOGY INST OF HEBEI ACAD OF SCI
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