Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of bone repair material having multi-dimensional channel structure

A channel structure and bone repair technology, applied in the field of biomedical materials, can solve the problems of poor pore permeability, small pore size, low mechanical properties of artificial bone repair materials, etc. Effect

Inactive Publication Date: 2016-03-23
宋占涛
View PDF12 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defects of low mechanical properties, small pore diameter and poor pore permeability of artificial bone repair materials, the present invention provides a method for preparing bone repair materials with a multi-dimensional channel structure, which adopts the following technical solutions:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of bone repair material having multi-dimensional channel structure
  • Preparation method and application of bone repair material having multi-dimensional channel structure
  • Preparation method and application of bone repair material having multi-dimensional channel structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Bone repair material preparation

[0061] Step 1 Prepare the base material

[0062] Weigh 50g of mineralized collagen material (water content is 80%), add ceramic powder 2g therein, stir clockwise with the rotating speed of 100rpm, adjust the pH value to 7.0 with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye, Then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitation, make the coagulation enzyme activity be 1600 μ g / g, add 37.5g collagen material (the purity of collagen is 40mg / g), continue to stir uniformly in the same direction, and adjust the precipitation to make the composite mineral The pH value of the collagen matrix is ​​7.2, and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and t...

Embodiment 2

[0075] Step 1 Prepare the base material

[0076] Weigh 65g mineralized collagen material (water content is 80%), add ceramic powder 2g therein, stir clockwise with the rotating speed of 100rpm, then adjust the pH value to 7.0 with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye , and then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitate to make the coagulase activity 3200 μg / g, add 75g of collagen material (the purity of collagen is 40mg / g), continue to stir evenly in the same direction, and adjust the precipitate to make the composite mineralization The pH of the collagen matrix is ​​7.2 and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and then continue to use 1.0M phosphoric acid solution and...

Embodiment 3

[0089] Step 1 Prepare the base material

[0090] Weigh 50g mineralized collagen material (water content is 80%), add ceramic powder 1g therein, stir clockwise with the rotating speed of 100rpm, then adjust the pH value to 7.0 with 1.0M phosphoric acid solution and 1.0M sodium hydroxide lye , and then adjust the pH value to 7.2 with 0.5M sodium carbonate solution, and the conductivity is 1.5ms / cm. Stand still for 30 minutes, then centrifuge at 10000rpm at 4°C for 30 minutes to remove the supernatant. Add Staphylococcus aureus fermentation liquid filtrate to the precipitate to make the coagulase activity 1600 μg / g, add 75g of collagen material (the purity of collagen is 40mg / g), continue to stir evenly in the same direction, and adjust the precipitate to make the complex mineralization The pH of the collagen matrix is ​​7.2 and the conductivity is 3.0ms / cm. At greater than 1.01×10 2 Degas under Pa vacuum conditions, and then continue to adjust with 1.0M phosphoric acid soluti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
bending strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method and application of a bone repair material having a multi-dimensional channel structure. The bone repair material is formed by stacking at least two laminated substrate structure layers, wherein each of the substrate structures is provided with through holes and grooves, and each of the substrate structures is prepared through substrate material preparation, substrate prefabricating, filler preparation, filling, stacking, forming, heat processing and heat treatment. According to the bone repair material prepared by the invention, three-dimensional network channels are constructed by the through holes and the grooves of the substrate structures and the channels are filled with collagen fibers, so that the bone repair material is conducive to cell adhesion growth and the in-growth of blood vessels and nerves, and the bone repair material is also convenient for transfer of nutrient substances and excretion of cell metabolites; meanwhile, cells are uniformly distributed inside the material, which is conducive to the formation of uniform and consistent tissues inside a stent; and the structural material can achieve firm biological chimerism with new bone tissues and can keep a good structural stability during degrading.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a bone repair material for clinical application, in particular to a preparation method and application of a multidimensional porous bone repair material with enhanced strength and sustained-release therapeutic effect. Background technique [0002] Bone defect is a very common disease in clinical practice, but the repair of bone defect is still a difficult problem in orthopedic clinics. Although scientific and technological workers have done a lot of work in the research and preparation of clinical bone repair materials over the years, great progress has been made. But there should be many problems. [0003] The bone quality of natural bone is divided into compact bone and cancellous bone according to the arrangement of the bone plates and the density of the spatial structure. The ordered anisotropic structure mainly meets the needs of its mechanical properties. Bone tissue is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/42A61L27/54A61L27/56
CPCA61F2/28A61F2002/30003A61F2002/30199A61F2002/30385A61L27/425A61L27/427A61L27/54A61L27/56A61L2300/30A61L2300/412A61L2430/02
Inventor 宋占涛
Owner 宋占涛
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com