Medical catheter and method for forming antibacterial hydrophilic coating on surface of medical catheter

A medical catheter and hydrophilic coating technology, applied in the field of medical devices, can solve problems such as use restrictions and biological toxicity, and achieve the effects of reducing negative effects, reducing biological toxicity and high action efficiency

Inactive Publication Date: 2016-03-23
JIANGSU BAIHUA ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional hydrophilic coatings are antibacterial and usually use metal nanomaterials such as silver. H

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1

[0038] First, surface pretreatment is performed on the PU catheter. Take the catheter, ultrasonically wash it in ethanol solution for 10 minutes, and then ultrasonically clean it with distilled water for 10 minutes to remove impurities on the surface of the catheter. After drying, place it in a UV radiation room for 1 hour under ultraviolet light.

[0039] Next, dip-coat the coupling agent: Take 68mL of methanol, 20mL of ethanol, 10mL of distilled water and 2mL of glacial acetic acid, and add them to the beaker in turn. Stir at 15°C to 30°C for 15 minutes, add 4mL of silane coupling agent KH-792 while continuing to stir, and stir evenly to prepare a coupling agent solution. Put the surface-treated catheter into the coupling agent solution and completely immerse it for 2 hours, take it out and irradiate it with UV for 30 minutes until it is completely dry. This dip-irradiation was repeated 3 times.

[0040] Again, apply an antimicrobial hydrophilic coating...

Example Embodiment

[0045] Example 2

[0046] First, surface pretreatment is performed on the PU catheter. Processing method is with embodiment 1.

[0047] Next, dip-coat the coupling agent. Processing method is with embodiment 1.

[0048] Again, apply an antimicrobial hydrophilic coating. Take 0.2 g of graphene oxide, slowly add it into a beaker containing 20 mL of 5% polylysine solution while stirring, and perform ultrasonic treatment for 3 hours to obtain a cement-like graphene oxide dispersion. Add 120mL of absolute ethanol and 80mL of ethyl acetate into the beaker, stir at 15°C to 30°C for 15 minutes, add 4mg of PVP during the stirring process, and after it is completely dissolved by ultrasonic treatment, add 0.4mg of ethyl cellulose during the stirring process , and continue stirring until completely dissolved to obtain a hydrophilic polymer solution. Take the prepared hydrophilic polymer solution, slowly add it into the graphene oxide dispersion in the stirring process, stir evenly, a...

Example Embodiment

[0052] Example 3

[0053] First, surface pretreatment is performed on the PU catheter. Processing method is with embodiment 1.

[0054] Next, dip-coat the coupling agent. Take 68mL of methanol, 20mL of ethanol, 10mL of distilled water and 2mL of glacial acetic acid, and add them to the beaker in turn. Stir at 15°C to 30°C for 15 minutes, add 2 mL of silane coupling agents KH-792 and KH602 respectively during the stirring process, and stir evenly to prepare a coupling agent solution. Put the surface-treated catheter into the coupling agent solution and completely immerse it for 2 hours, take it out and irradiate it with UV for 30 minutes until it is completely dry. This dip-irradiation was repeated 3 times.

[0055] Again, apply an antimicrobial hydrophilic coating. Take 0.2 g of graphene oxide, slowly add it into a beaker containing 10 mL of 5% polylysine solution while stirring, and perform ultrasonic treatment for 3 hours to obtain a cement-like graphene oxide dispersio...

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Abstract

The invention relates to a medical catheter and a method for forming an antibacterial hydrophilic coating on the surface of the medical catheter. The method includes the following steps of preparing graphene oxide dispersoid, dissolving hydrophilic polymers and cellulose ester in organic solvent to form a hydrophilic macromolecular solution, adding the hydrophilic macromolecular solution to the graphene oxide dispersoid in the stirring process to form an antibacterial hydrophilic macromolecular solution, soaking the catheter in a coupling agent solution after conducting surface processing on the catheter so that the surface of the catheter can be dip-coated with a coupling agent layer, soaking the catheter coated with the coupling agent layer in the antibacterial hydrophilic macromolecular solution, and preparing the medical catheter with the antibacterial hydrophilic coating after the catheter is taken out, dried and solidified. Due to the fact that the antibacterial hydrophilic coating is formed on the surface of the catheter, the coating contains graphene oxide, other hydrophilic macromolecules and other components, the catheter can have excellent antibacterial and bacteriostatic capacity, the contact angle of the catheter and water is reduced, and the surface of the catheter can have the ultra-strong lubrication effect and the bacteriostatic effect at the same time.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a medical catheter and a method for forming an antibacterial hydrophilic coating on its surface. Background technique [0002] At present, medical catheter technology is widely used in the diagnosis and treatment of various diseases, and with the development of modern technology, its application scope is expanding day by day. Various monitoring tubes for nutrition injection and sewage discharge, various catheters for diagnosis and interventional therapy, etc. [0003] Ideal medical catheter materials should have good hydrophilicity and biocompatibility. However, the current domestic medical catheter materials are mostly hydrophobic materials, such as PVC, polyurethane, latex or silicone rubber, etc., which bring convenience to clinical treatment, but also have some problems. Because it is a hydrophobic material, the friction force is relatively large when used, and patients are o...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/10A61L31/14
CPCA61L31/08A61L31/10A61L31/14A61L2420/02A61L2420/06C08L1/28C08L39/06
Inventor 李志刚宋建新薛耀宗周海燕邱晓琴
Owner JIANGSU BAIHUA ELECTRONICS
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