Multifunctional temperature-sensitive gel composite dressing for wound healing and its preparation and use method

Abstract

The invention discloses a multifunctional temperature-sensitive gel composite dressing for wound healing and preparation and usage thereof. The dressing comprises a quaternized chitosan derivative and an aldehyde-terminated temperature-sensitive polymer, a mass ratio of the two components is 1:15-1:25, wherein a molecular weight of chitosan for preparing quaternized chitosan is between 100 thousands and 1000 thousands, the degree of deacetylation is above 90%, and the degree of quaternized substitution is 10%-45%. The dressing is a thick liquid easy to apply to a wound at room temperature, and after it is applied to the wound, a gel film coating may form within 1 min. The temperature-sensitive gel composite dressing prepared based on the invention has autonomous antibacterial and anti-inflammatory effects and good film-forming stability, may also provide a wet environment and a sustained drug release function and is useful for treating and healing wounds such as diabetic foot ulcers.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a multifunctional temperature-sensitive gel composite dressing for wound healing and a preparation and application method thereof. Background technique [0002] The skin is the first barrier of the human body's defense function and the first immune defense line of the human body, which is closely related to human health. However, it is difficult to avoid various cuts, abrasions, burns and chemical burns in life. Once the wound is formed, it is very easy to be attacked by pathogenic microorganisms; especially for diabetic patients, small wounds can easily lead to further ulcers, and then form Diabetic foot, severe cases may lead to amputation. [0003] An ideal wound dressing should be able to control secondary infection of the ulcer on the one hand, and promote rapid wound healing on the other hand. Medical dressings developed in recent years mainly include films...

AI Technical Summary

Problems solved by technology

Among them, the hydrogel is made of polymer materials, which can not only absorb the exudate from the wound, but also retain the exudate in the dressing, so that the wound can generate a slightly moist, slightly acidic and hypoxic environment, and promote tissue repair and re-epithelialization. Not only that, the porous network structure of hydrogel can also embed and control release some drugs that can accelerate wound healing, so it has attracted much attention. However, there are still the following main problems in research and clinical application in this field : the one, existing hydrogel dressing itself does not possess antibacterial function, often needs to add antibacterial components such as a large amount of antibiotics or easily agglomerated nano-silver, as disclosed in patent CN105079862A " a kind of medical antibacterial dressing and preparation method thereof ", patent CN104857551A The disclosed "A silver-containing antibacterial dressing and its preparation method" all use nano-silver as an antibacterial additive; secondly, the wound application effect is not ideal, and the formed hydrogel dressing at room temperature is difficult to evenly coat the wound surface, and mechanical Hydrogel dressings with poor performance are difficult to form a stable coating on the wound surface, which limits their application

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