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Nano-graphene material special for drug carrier and preparing method

A nano-graphene and carrier technology, which is applied in the field of nano-graphene materials and preparations for drug carriers, can solve the problems of limiting the wide application of reduced graphene, complicated process, poor controllability, etc., and achieves controllable reduction degree, simple process, Inexpensive effect

Inactive Publication Date: 2016-07-13
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing process usually uses hydrazine hydrate, vitamin C, protein, galactose, glucose and other reagents to reduce graphene oxide, but in the reduction process, a large number of surface functional groups are reduced, resulting in material agglomeration, which is difficult to disperse in the solution, which limits the reduction of graphite. Although many researchers have developed many methods to improve the solution dispersion of reduced graphene, most of these methods have problems such as complex process, poor controllability, and high cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Take flake graphite, then add a certain amount of concentrated sulfuric acid, mix, then add a certain amount of potassium permanganate, bathe in a water bath at 30°C, stir intermittently for 4 hours, then stop the reaction, then add a certain amount of water to raise the temperature of the system to 80°C, and keep it for 60 minutes, then add hydrogen peroxide, stir, wash with water to remove various ions in the system, until the pH value reaches 4-5, and obtain graphite oxide mother liquor. The mass ratio between the reactants is strong oxidizing acid:potassium-containing strong oxidizing agent:hydrogen peroxide:graphite=25:3:2:1.

[0026] (2) Disperse the graphite oxide obtained in step (1) in a certain amount of deionized water and ultrasonically disperse for 6 hours at an ultrasonic frequency of 250 Hz to obtain a graphite oxide colloid with good suspension stability.

[0027] (3) Add the aqueous solution of fatty alcohol polyoxyethylene ether aqueous solution un...

Embodiment 2

[0030] (1) Take flake graphite, then add a certain amount of concentrated sulfuric acid, mix, then add a certain amount of potassium permanganate, bathe in a water bath at 40°C, stir intermittently for 8 hours, then stop the reaction, then add a certain amount of water to raise the temperature of the system to 60°C, and keep it for 60 minutes, then add hydrogen peroxide, stir, wash with water to remove various ions in the system, until the pH value reaches 5, and obtain graphite oxide mother liquor. The mass ratio among the reactants is strong oxidizing acid:potassium-containing strong oxidizing agent:hydrogen peroxide:graphite=10:3:1:1.

[0031](2) Disperse the graphite oxide obtained in step (1) in a certain amount of deionized water and disperse it ultrasonically for 8 hours at an ultrasonic frequency of 300 Hz to obtain a graphite oxide colloid with good suspension stability.

[0032] (3) Add the aqueous solution of fatty alcohol polyoxyethylene ether aqueous solution unde...

Embodiment 3

[0035] (1) Take flake graphite, then add a certain amount of concentrated sulfuric acid, mix, then add a certain amount of potassium perchlorate, bathe at 30°C, stir intermittently for 12 hours and stop the reaction, then add a certain amount of water to raise the temperature of the system to 80°C , and kept for 60 minutes, then added hydrogen peroxide, stirred, and washed with water to remove various ions in the system until the pH value reached 4-5 to obtain graphite oxide mother liquor. The mass ratio between the reactants is strong oxidizing acid:potassium-containing strong oxidizing agent:hydrogen peroxide:graphite=30:6:2:1.

[0036] (2) Disperse the graphite oxide obtained in step (1) in a certain amount of deionized water and ultrasonically disperse for 6 hours at an ultrasonic frequency of 250 Hz to obtain a graphite oxide colloid with good suspension stability.

[0037] (3) Add the aqueous solution of fatty alcohol polyoxyethylene ether aqueous solution under mechanic...

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Abstract

The invention relates to a nano-graphene material special for a drug carrier and a preparing method thereof.The method comprises the steps that crystalline flake graphene is oxidized through an HUMMMERS method so that graphene oxide can be obtained, the graphene oxide is subjected to micromechanical ultrasonic peeling so that single-layer nano-graphene oxide can be obtained; then, fatty alcohol-polyoxyethylene ether is used for modifying the single-layer nano-graphene oxide, modified graphene oxide is obtained, the water solubility and dispersity of the modified graphene oxide are improved, and cyanate ester modifying amphiphilic polymers are used for reducing the modified graphene oxide into graphene; finally, the nano-graphene material with superior water solubility and physiological stability is obtained.The obtained reduction graphene is good in water solubility, wide in stable dispersion solvent range, good in biocompatibility, good in physiological stability and capable of meeting the application requirements in the field of drug carriers.According to the method, the technology is simple, price is low, reduction degree is controllable, functionalized graphemes with different reduction degrees and dispersities can be acquired, and the application range of graphene is expanded in the field of drug carriers.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to a special nano-graphene material for drug carriers and a preparation method. Background technique [0002] The development of new and effective drug delivery systems to improve the therapeutic profile and efficacy of therapeutic drugs is one of the key issues facing modern medicine. Advances in nanoscience and nanotechnology have enabled the synthesis of new nanomaterials and promoted the development of many new drug delivery systems. [0003] The discovery of graphene in recent years has attracted increasing research attention to explore the application of this new material in drug delivery. Graphene is a single-layer two-dimensional honeycomb lattice structure formed by sp2 hybridization of carbon atoms. Since its discovery in 2004, it has aroused great interest in the entire scientific community. Due to its unique chemical structure and geometry, graphene has extraordi...

Claims

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Application Information

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IPC IPC(8): C01B31/04B82Y40/00A61K47/04
CPCA61K47/02C01B2204/20
Inventor 陈庆叶任海曾军堂陈兵
Owner CHENDU NEW KELI CHEM SCI CO LTD