Gallocatechin palmitate and alcohol compound disinfectant and preparation method thereof

A technology of gallocatechin and gallic acid, applied in botany equipment and methods, disinfectants, antiviral agents, etc., can solve the problem of no long-term prevention of virus infection, etc., and achieve simple operation, feasible method, and convenient use Effect

Inactive Publication Date: 2016-08-17
武汉艾文斯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] China's disinfectant market currently does not have long-term products to prevent virus infection

Method used

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  • Gallocatechin palmitate and alcohol compound disinfectant and preparation method thereof
  • Gallocatechin palmitate and alcohol compound disinfectant and preparation method thereof
  • Gallocatechin palmitate and alcohol compound disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A kind of fat-soluble gallocatechin gallate palmitate and alcohol compound disinfectant, it is made from the raw material of following weight parts (best value):

[0054] Raw material parts by weight

[0055] Organic solution accounted for 88% of the total volume.

[0056] Inorganic solution accounted for 22% of the total volume.

[0057] The organic solution is one of glycerin, alcohol, vitamin E (antioxidant), fat-soluble gallocatechin gallate palmitate or any mixture of two to four.

[0058] The inorganic solution is one or two of deionized water, polyquaternium-10, benzalkonium chloride, cetyltrimethylammonium chloride, carbomer Ultrez 20 and aloe extract Any mixture of six.

[0059] The deionized water accounts for 10 or 12 or 14 or 16 or 18 or 20% of the total volume, alcohol (common) accounts for 55 or 60 or 65 or 70 or 75% of the total volume, and glycerol accounts for 0.001 or 0.008 of the total volume Or 0.5 or 1.5 or 5 or 8 or 10 or 12%, the fat-soluble g...

Embodiment 9

[0076] Embodiment 9: Stability test of disinfectant solution stored at 25°C:

[0077] The disinfectant was stored in a 48-degree incubator (humidity 75%) for 6 months, stored at room temperature for 2 years, and the content of the fat-soluble gallocatechin gallic acid palmitate was detected every six months. The results are shown in Table 1

[0078] Table 1 The stability test of the disinfectant solution of the embodiment of the present invention stored at 25°C is shown in the following table:

[0079]

[0080]

[0081] The experimental results show that the disinfectant has stable properties and effective disinfection active ingredients.

Embodiment 10

[0082] Embodiment 10: The detection of the bactericidal effect of disinfectant on Escherichia coli and Staphylococcus aureus is carried out according to the method specified in the "Technical Specification for Inspection of Disinfection Products" issued by the former Ministry of Health, as follows:

[0083] 1. The purpose of the experiment: To test the bactericidal effect of the disinfectant on Escherichia coli and Staphylococcus aureus.

[0084] 2. Sample source: The tested sample EGCG palmitate and alcohol compound disinfectant is the product prepared in Examples 1, 2, 3, 4, 5, 6, 7, and 8 of the present invention.

[0085] 3. Experimental steps

[0086] 1. Test equipment

[0087] 1) Strains: Staphylococcus aureus ATCC 6538, Escherichia coli 8099, Candida albicans ATCC10231

[0088] 2) Phosphate buffer: see Appendix A.

[0089] 3) Sterile distilled water.

[0090] 4) Hard water for disinfectant dilution: see Appendix A.

[0091] 5) Organic interfering substances: 3% BSA...

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Abstract

The invention discloses a fat-soluble gallocatechin gallate palmitate and alcohol compound disinfectant and a preparation method thereof, which are prepared by mixing an organic solution and an inorganic solution. Organic solution contains glycerin, alcohol, vitamin E, fat-soluble gallocatechin gallate palmitate. The inorganic solution contains ion-free water, gel polymer, surfactant, aloe vera extract, and acid-base regulator. Steps: 1. Prepare an organic solution: add fat-soluble gallocatechin gallate palmitate, alcohol and auxiliary materials and mix uniformly to obtain an organic solution. 2. Prepare inorganic solution: polyquaternium-10, benzalkonium chloride, cetyltrimethylammonium chloride, carbomer Ultrez 20, and aloe vera extract dissolved in deionized water. 3. Add the organic solution to the inorganic solution to obtain a disinfectant. The formula is reasonable and easy to use. Long-acting, efficient, non-toxic, anti-oxidant. It does not contain pollutants and toxic substances, and is suitable for disinfection of human skin surfaces and object surfaces.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically to a fat-soluble gallatechin gallate palmitate (Epigallocatechin gallate-Palmitate, EGCG-p) and alcohol compound disinfectant, and also to a fat-soluble gallatechin The preparation method of gallic acid palmitate and alcohol compound disinfectant can be used as a surface disinfectant in families, hospitals, schools, public places, poultry farms, animal husbandry, and other places that may be infected by bacteria or viruses. It not only kills the existing bacteria and viruses in time, but also maintains the effect of inhibiting viruses for a long time. Background technique [0002] Epigallocatechin gallate (Epigallocatechin gallate, EGCG) is the most effective active ingredient in tea polyphenols, belonging to catechins. EGCG has antibacterial, antiviral, antioxidative, antiarteriosclerosis, antithrombotic, antiangioproliferative, antiinflammatory and antitumor effects, due to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K31/353A61P31/00A61P31/04A61P31/12A01N65/42A01N43/16A01N31/02A01N33/12A01P1/00A61K31/045A61K31/14
CPCA61K36/896A01N31/02A01N33/12A01N43/16A01N65/00A01N65/42A61K31/045A61K31/14A61K31/353
Inventor 吴建国徐德邬开朗张祺杨庆雨刘映乐谭秋萍刘芳
Owner 武汉艾文斯生物科技有限公司
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