A kind of composite nanofiber film and preparation method thereof

A composite nanofiber, memory technology, applied in the direction of animal fiber, fiber processing, fiber type, etc., can solve the problems of non-complementary or coexisting functions, unsafe cost, functional limitations, etc., to achieve broad-spectrum antibacterial activity compatibility, The effect of good suction rate and good cytocompatibility

Active Publication Date: 2018-10-12
CENT TESTING INT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing nanofiber membranes used for wound dressings also have some shortcomings: their functions are limited or single, and the functions cannot be complementary or exist at the same time. For example, the nanofiber membrane wound dressings with strong antibacterial properties have cytotoxicity; In addition, in order to improve the strength of the fiber membrane, a chemical crosslinking agent is introduced, but it brings unsafe and cost-increasing problems

Method used

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  • A kind of composite nanofiber film and preparation method thereof
  • A kind of composite nanofiber film and preparation method thereof
  • A kind of composite nanofiber film and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Add 40g of polycaprolactone diol (molecular weight: 4000g / mol) and 3.6g of 1,4-butanediol into a 100ml three-necked flask equipped with a vacuum port, a thermometer and mechanical stirring. Heat the oil bath to 100 degrees, vacuum dehydration at 100 Pa for 1.5 hours, then remove the vacuum and cool down to 80 degrees, add 12.5 grams of MDI, stir rapidly for 20 seconds, pour into a polytetrafluoroethylene tray and mature in an oven at 100 degrees for 24 Shape-memory polyurethane is obtained in hours.

Embodiment 2

[0035]Add 40 g of PBA (molecular weight 4000 g / mol) in a 100 ml three-neck flask with a vacuum port, a thermometer, and mechanical stirring. Heat the oil bath to 100°C, vacuum dehydrate at 100 Pa for 1.5 hours, then release the vacuum and cool down to 80°C, add 5 grams of MDI, and control the reaction temperature to 80°C for 2 hours under the protection of nitrogen. Afterwards, 65 g of DMAc was added to dissolve, and then 30 g of DMAc solution containing 2% EDA was slowly added dropwise under stirring, and the reaction was continued for 2 hours to obtain a shape memory polyurethane solution. The shape-memory polyurethane can be obtained by precipitating and drying a polyurethane solution in water.

[0036] It can be understood that the shape-memory polyurethane can also adopt other temperature-sensitive shape-memory polyurethanes with the crystallization-melting temperature as the transition temperature, and its synthetic raw materials are crystalline polyether or polyester po...

Embodiment 3

[0039] Weighing 0.15g molecular weight is 200000, deacetylation degree is 85%, the chitosan of viscosity value 500mpa.s, 0.15g molecular weight is 30000, the gelatin of Bloom value 200, and the shape memory that 0.70g embodiment 1 makes Polyurethane is dissolved in a mixed acidic solvent with a weight ratio of formic acid: glacial acetic acid=1:1, so that its concentration is 10%. Afterwards, the composite nanofiber membrane was prepared by electrospinning. The electrospinning parameters were: voltage 15kv, distance between nozzle and collecting plate 10cm, collecting plate rotation speed 10rpm, temperature 22±2°C, humidity 35±3% .

[0040] Carry out post-treatment at last, and post-treatment step is: soak described composite nanofibrous membrane in concentration be 1*10 -5 mol / L silver sulfate solution for 3 hours; the environment is naturally dry.

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Abstract

The invention discloses a composite nanometer fiber film formed by compositing chitosan, gelatin and shape memory polyurethane; the chitosan and gelatin are prepared by the weight ratio of (0.5-2):1; the total weight of the chitosan and gelatin and the weight of the shape memory polyurethane are prepared by the ratio of (0.2-2):1; the composite nanometer fiber film preparation method comprises the following steps: dissolve the chitosan, gelatin and shape memory polyurethane into a solvent so as to obtain a homogeneous solution; using a static spinning method to process the homogeneous solution so as to obtain the composite nanometer fiber film; carrying out proper after treatment for the composite nanometer fiber film. The composite nanometer fiber film is good in cell compatibility, wide spectrum antibiosis activity, haemostasis performance, permeability, mechanical strength, shape memory function, water vapor transmittance, heat stability and imbibition rate, and can be applied as biology medical dressing.

Description

technical field [0001] The invention relates to a shape-memory polymer material, in particular to a composite nanofiber membrane material which can be used as a medical wound dressing. Background technique [0002] Electrospinning technology is one of the traditional and efficient nanofiber preparation methods, which has played an important role in promoting the development of nanotechnology in recent years. At present, nanofibrous membranes are generally non-woven membranes obtained by using polymer materials with certain functions and activities through an optimized electrospinning process. Such non-woven fabrics usually have good air permeability, good water vapor transmission rate, good liquid absorption rate and other functions, and at the same time, they can have a structure and function similar to extracellular matrix, which can promote the rapid recovery of damaged tissues. repair. Therefore, multifunctional nanofibrous membranes have broad application prospects in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4382D04H1/728A61L15/32A61L15/28A61L15/26A61L15/44A61L15/42D06M11/65D06M11/56D06M101/10D06M101/38
Inventor 胡金莲谭淋
Owner CENT TESTING INT GRP CO LTD
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