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Maca extract as well as preparation method and application thereof

A maca extract and extract technology, applied in the field of biomedicine, can solve the problems of difficulty in fully obtaining maca anti-fatigue active ingredients, low use potency, and low content of active ingredients, and achieve raw material utilization and active ingredients. High efficiency, improved anti-fatigue effect, high content of active ingredients

Active Publication Date: 2016-09-07
宝鸡欧泽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional maca extract preparation methods include water extraction, alcohol extraction, alcohol-water extraction, water extraction and alcohol precipitation, and alcohol extraction and water precipitation. It is difficult to fully obtain the anti-fatigue active ingredients of Maca. Complicated, the existing maca extract has shortcomings such as low active ingredient content and low use potency, so there is an urgent need for an extraction method with high active ingredient content and high utilization rate of maca extract

Method used

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  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof

Examples

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Embodiment 1

[0030] Maca extract described in the present embodiment is obtained by following preparation method, and its steps include:

[0031] Ⅰ. Weigh 12 kg of fresh maca root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with petroleum ether (60-90°C), the ratio of solid to liquid is 1:10, the extraction temperature is 70°C, and filter to obtain the extract. liquid, extracted 2 times, each time 2h, combined two extracts, concentrated under reduced pressure, silica gel column chromatography on the concentrated solution, gradient elution with ethyl acetate-petroleum ether system (10:90, 25:75, 35 :65, 50:50), collect the eluate of macamide component mainly composed of N-benzyl linoleamide, concentrate the eluate under reduced pressure, and dry it in vacuum to obtain extract A;

[0032] Ⅱ. The above-mentioned maca extraction residue was evaporated to dryness naturally, inactivated at 105°C for 30 minutes, extracted with 80% ethanol aqueous solution, the ratio of solid...

Embodiment 2

[0036] The maca extract of this embodiment is obtained by the following preparation method, and its steps include:

[0037]Ⅰ. Weigh 12 kg of maca fresh root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with n-hexane, the ratio of solid to liquid is 1:10, and the extraction temperature is 60°C, filter to obtain the extract, and extract twice, Each time for 2 h, the two extracts were combined, concentrated under reduced pressure, and the concentrated solution was subjected to silica gel column chromatography, and the ethyl acetate-petroleum ether system was used for gradient elution (10:90, 25:75, 35:65, 50: 50), collecting the eluate of the macamide component mainly composed of N-benzyllinoleamide, concentrating the eluate under reduced pressure, and drying in vacuum to obtain extract A;

[0038] Ⅱ. The above-mentioned maca extraction residue was evaporated to dry naturally, inactivated at 105°C for 30 minutes, extracted with 65% ethanol aqueous solution, t...

Embodiment 3

[0042] Maca extract of the present invention is obtained by following preparation method, and its steps comprise:

[0043] Ⅰ. Weigh 12 kg fresh maca root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with n-hexane, the ratio of solid to liquid is 1:5, and the extraction temperature is 60°C, filter to obtain the extract, and extract twice, Each time for 2 hours, the two extracts were combined, concentrated under reduced pressure, and the concentrated solution was subjected to neutral alumina column chromatography, and eluted with a gradient ethyl acetate-methanol system (40:60, 30:70, 20:80, 10 :90), collecting the macamide component eluate mainly composed of N-benzyllinoleamide, concentrating the eluent under reduced pressure, and drying in vacuum to obtain extract A;

[0044] Ⅱ. The above-mentioned maca extraction residue was evaporated to dry naturally, inactivated at 105°C for 30 minutes, extracted with 65% ethanol aqueous solution, the ratio of solid to...

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Abstract

The invention discloses a maca extract as well as a preparation method and an application thereof. The maca extract mainly consists of the following materials in percentage by mass: 28-50% of total maca amide, 25-40% of aromatic glucosinolate, 4-12% of total saponins and 1-8% of adenosine, wherein the content of N-benzyl linoleamide in the total maca amide is 35-60% of the content of the total maca amide. The maca extract disclosed by the invention is high in stability, low in content of impurities and rich in various bio-active ingredients; the maca extract has a good effect on improving exercise-induced fatigue resistance and central fatigue resistance; and the maca extract is capable of significantly improving an anti-fatigue effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a maca extract and its preparation method and application. Background technique [0002] Maca (Lepdium meyenii Walpers, Maca) is an annual or biennial herb of the genus Lepidium in the family Brassicaceae. The introduction and cultivation of maca has realized large-scale planting. Maca is not only rich in protein, unique amino acid composition, a variety of unsaturated fatty acids, mineral elements and vitamins, but also contains aromatic glucosinolates, macamides, macaene, sterols, adenosine, saponins, Secondary metabolites such as imidazole alkaloids have a variety of health care functions and therapeutic effects, such as enhancing energy, anti-fatigue, improving fertility, relieving stress, improving sexual function, improving sleep, neuroprotection, enhancing immunity and anti-tumor, etc. side effects. [0003] With the acceleration of the pace of life, labor and socia...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P39/00A61P25/28
CPCA61K36/31A61K2236/33A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55
Inventor 代鹏飞余元涛金文闻余金龙
Owner 宝鸡欧泽生物科技有限公司
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