Maca extract as well as preparation method and application thereof

A maca extract and extract technology, applied in the field of biomedicine, can solve the problems of difficulty in fully obtaining maca anti-fatigue active ingredients, low use potency, and low content of active ingredients, and achieve raw material utilization and active ingredients. High efficiency, improved anti-fatigue effect, high content of active ingredients

Active Publication Date: 2016-09-07
宝鸡欧泽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional maca extract preparation methods include water extraction, alcohol extraction, alcohol-water extraction, water extraction and alcohol precipitation, and alcohol extraction and water precipitation. It is difficult to fully obtain the anti-fatigue acti

Method used

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  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof
  • Maca extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Maca extract described in the present embodiment is obtained by following preparation method, and its steps include:

[0031] Ⅰ. Weigh 12 kg of fresh maca root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with petroleum ether (60-90°C), the ratio of solid to liquid is 1:10, the extraction temperature is 70°C, and filter to obtain the extract. liquid, extracted 2 times, each time 2h, combined two extracts, concentrated under reduced pressure, silica gel column chromatography on the concentrated solution, gradient elution with ethyl acetate-petroleum ether system (10:90, 25:75, 35 :65, 50:50), collect the eluate of macamide component mainly composed of N-benzyl linoleamide, concentrate the eluate under reduced pressure, and dry it in vacuum to obtain extract A;

[0032] Ⅱ. The above-mentioned maca extraction residue was evaporated to dryness naturally, inactivated at 105°C for 30 minutes, extracted with 80% ethanol aqueous solution, the ratio of solid...

Embodiment 2

[0036] The maca extract of this embodiment is obtained by the following preparation method, and its steps include:

[0037]Ⅰ. Weigh 12 kg of maca fresh root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with n-hexane, the ratio of solid to liquid is 1:10, and the extraction temperature is 60°C, filter to obtain the extract, and extract twice, Each time for 2 h, the two extracts were combined, concentrated under reduced pressure, and the concentrated solution was subjected to silica gel column chromatography, and the ethyl acetate-petroleum ether system was used for gradient elution (10:90, 25:75, 35:65, 50: 50), collecting the eluate of the macamide component mainly composed of N-benzyllinoleamide, concentrating the eluate under reduced pressure, and drying in vacuum to obtain extract A;

[0038] Ⅱ. The above-mentioned maca extraction residue was evaporated to dry naturally, inactivated at 105°C for 30 minutes, extracted with 65% ethanol aqueous solution, t...

Embodiment 3

[0042] Maca extract of the present invention is obtained by following preparation method, and its steps comprise:

[0043] Ⅰ. Weigh 12 kg fresh maca root, slice it, dry it at 55°C, crush it through 10 meshes, extract it with n-hexane, the ratio of solid to liquid is 1:5, and the extraction temperature is 60°C, filter to obtain the extract, and extract twice, Each time for 2 hours, the two extracts were combined, concentrated under reduced pressure, and the concentrated solution was subjected to neutral alumina column chromatography, and eluted with a gradient ethyl acetate-methanol system (40:60, 30:70, 20:80, 10 :90), collecting the macamide component eluate mainly composed of N-benzyllinoleamide, concentrating the eluent under reduced pressure, and drying in vacuum to obtain extract A;

[0044] Ⅱ. The above-mentioned maca extraction residue was evaporated to dry naturally, inactivated at 105°C for 30 minutes, extracted with 65% ethanol aqueous solution, the ratio of solid to...

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Abstract

The invention discloses a maca extract as well as a preparation method and an application thereof. The maca extract mainly consists of the following materials in percentage by mass: 28-50% of total maca amide, 25-40% of aromatic glucosinolate, 4-12% of total saponins and 1-8% of adenosine, wherein the content of N-benzyl linoleamide in the total maca amide is 35-60% of the content of the total maca amide. The maca extract disclosed by the invention is high in stability, low in content of impurities and rich in various bio-active ingredients; the maca extract has a good effect on improving exercise-induced fatigue resistance and central fatigue resistance; and the maca extract is capable of significantly improving an anti-fatigue effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a maca extract and its preparation method and application. Background technique [0002] Maca (Lepdium meyenii Walpers, Maca) is an annual or biennial herb of the genus Lepidium in the family Brassicaceae. The introduction and cultivation of maca has realized large-scale planting. Maca is not only rich in protein, unique amino acid composition, a variety of unsaturated fatty acids, mineral elements and vitamins, but also contains aromatic glucosinolates, macamides, macaene, sterols, adenosine, saponins, Secondary metabolites such as imidazole alkaloids have a variety of health care functions and therapeutic effects, such as enhancing energy, anti-fatigue, improving fertility, relieving stress, improving sexual function, improving sleep, neuroprotection, enhancing immunity and anti-tumor, etc. side effects. [0003] With the acceleration of the pace of life, labor and socia...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P39/00A61P25/28
CPCA61K36/31A61K2236/33A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55
Inventor 代鹏飞余元涛金文闻余金龙
Owner 宝鸡欧泽生物科技有限公司
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