Eye drops

A technology of eye drops and Scutellaria baicalensis extract, applied in the field of medicine, can solve problems such as antibiotic abuse and drug resistance, and achieve the effect of less irritating effect and alleviating eye interference.

Inactive Publication Date: 2016-12-14
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main components of existing eye drops are chloramphenicol, which is an antibiotic. Although the use effect i

Method used

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  • Eye drops

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Effect test

Embodiment 1

[0032] 78 parts by mass of normal saline, 26 parts of methylcellulose, 13 parts of sodium hyaluronate, 7 parts of taurine, 3 parts of triazole thioether indole derivatives , 14 parts [Ni(en) 3 ](L) 2 ·3H 2 O, 10 parts of hawthorn extract, 8 parts of Scutellaria baicalensis extract and 7 parts of preservative are uniformly mixed at normal temperature, wherein, the preservative consists of 8 parts of potassium sorbate by mass, 7 parts of ethyl paraben, 3 parts of sodium benzoate and Composed of 3 parts of sodium sulfite, after mixing evenly, the radiation intensity is 15kGy and the radiation dose rate is 3.6kGy / h. 60 Co-gamma radiation sterilization.

Embodiment 2

[0034] Dissolve 0.5mmol of nickel sulfate in 10mL of ethanol-water mixed solvent with a volume ratio of 1:l, and dissolve 1mmol of HL in 10mL of ethanol-water solvent, adjust the pH value of the solution to 5 with sodium hydroxide solution, It was gradually dropped into the above solution. After stirring at room temperature for 4 h, a large number of light green precipitates were formed, which were filtered, washed three times with 1:1 ethanol-water mixed solvent, and dried in vacuum at room temperature. Dissolve the obtained solid in 30 mL of ethanol under constant stirring, then add 1 mmol of ethylenediamine dropwise, the color of the solution changes from light green to lavender, stir at room temperature for 3 h, let the solution stand still, and obtain A purple single crystal was obtained, which was filtered, washed with a small amount of ethanol, and dried at room temperature, with a yield of 40% (calculated as nickel sulfate). [Ni(en) 3 ](L) 2 ·3H 2 O, IR (KBr) cm -...

Embodiment 3

[0036] Triazole mercaptoformamide derivatives are synthesized via the following route,

[0037] The synthesis methods of compound 2 and compound 3 are prior art.

[0038] Synthesis of Compound 4: Add 5.0 g (21.0 mmol) of Compound 3 and 3.0 mL (63.0 mmol) of 85% hydrazine hydrate (molar ratio 1:3) into a 50 mL round bottom flask, and let it stand for 48 h. After the reaction was complete, it was filtered with suction, and the filter cake was washed with water and dichloromethane in turn, and dried in vacuo to obtain a light yellow solid (compound 4).

[0039] Compound 5: Add 2.3 g (10.0 mmol) of compound 4 and 40.0 mL of absolute ethanol into a 100 mL three-necked flask, and drop 10 mmol of phenyl isothiocyanate after the solid is completely dissolved, reflux for 3 hours, cool, and a large amount of The white solid compound 5 was suction filtered, washed with a small amount of deionized water, and dried to obtain a white solid.

[0040] Synthesis of compound 6: 3.6 g (10.0 ...

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Abstract

The invention discloses eye drops, and belongs to the field of medicines. The eye drops are prepared from 78 mass parts of normal saline, 26 mass parts of methylcellulose, 13 mass parts of sodium hyaluronate, 7 mass parts of taurine, 3 mass parts of triazole sulfide indole derivatives, 14 mass parts of [Ni(en)3](L)2 3H2O, 10 mass parts of hawthorn fruit extracting solution, 8 mass parts of radix scutellariae extracting solution and 7 mass parts of preservative. The eye drops disclosed by the invention have the characteristics that the eye drops have no chloramphenicol and can be used for relieving symptoms such as eye dryness and hyperaemia; meanwhile, aiming at people wearing cosmetic contact lenses, the eye drops can be used for protecting lipid layers, water liquid layers and mucin layers on the surfaces of human eyeballs, is suitable for long-term use, and avoids drug resistance.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an eye drop. Background technique [0002] Color contact lenses can enlarge the eyes and make the whole person look more energetic, so they are very popular among modern people. However, wearing color contact lenses for a long time will make the eyes feel dry, easy to cause keratitis, and even eye congestion, serious eye diseases such as corneal hypoxia deformation and eye infection, corneal perforation, and even permanent blindness. In daily life, adding eye drops can relieve symptoms such as dry eyes and congestion, and at the same time reduce the risk of infection. But its main component of existing eye drops is chloramphenicol, is antibiotic, although use effect is good, long-term use of antibiotic can cause drug resistance, causes adverse consequences such as antibiotic abuse. Contents of the invention [0003] The purpose of the present invention is to: address the above-mention...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/08A61K47/38A61K47/36A61K47/12A61K47/14A61K47/02A61P31/04A61P31/10A61P27/02A61K31/427A61K33/24A61K31/185
CPCA61K36/734A61K9/0048A61K9/08A61K31/185A61K31/427A61K33/24A61K36/539A61K47/02A61K47/12A61K47/14A61K47/36A61K47/38A61K2236/37
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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