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Silk fibroin-alginate composite film, as well as preparation method and application thereof

A technology of silk fibroin and alginate, applied in the field of composite materials, can solve the problems of easy loss of small counterion molecules, unstable membrane dissolution, insufficient strength and flexibility, etc.

Inactive Publication Date: 2017-01-04
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the structure of sodium alginate contains a large number of hydrophilic groups such as carboxyl and hydroxyl groups, when it is dissolved in water, the dissociated small molecules of counter ions are easy to lose, resulting in the problem of unstable membrane dissolution. A single sodium alginate has a large High hydrophilicity, insufficient strength and flexibility after film formation

Method used

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  • Silk fibroin-alginate composite film, as well as preparation method and application thereof
  • Silk fibroin-alginate composite film, as well as preparation method and application thereof
  • Silk fibroin-alginate composite film, as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] First, degumming, centrifugation, filtration, dialysis, and concentration of the shredded silk cocoons were performed to obtain a silk fibroin solution with a mass fraction of 5%. In a hot water bath at 60°C, 2g of sodium alginate and 100ml of deionized water were used as raw materials. Use gentle stirring to configure sodium alginate aqueous solution; mix the aqueous solution containing 0.2g silk fibroin with the prepared sodium alginate aqueous solution evenly to obtain a silk fibroin-sodium alginate mixture, which is defoamed and left to stand for later use . The mixed solution is naturally spread on the glass plate by casting method, the solution thickness is 2mm, and the composite film is solidified with a calcium chloride aqueous solution with a mass fraction of 3%. The membrane is used as the standard, and then the calcium chloride on the surface of the membrane is washed with deionized water, and then dried naturally in a constant temperature and humidity chambe...

Embodiment 2

[0029] First, degumming, centrifugation, filtration, dialysis, and concentration of the shredded silk cocoons were performed to obtain a silk fibroin solution with a mass fraction of 5%. In a hot water bath at 60°C, 2g of sodium alginate and 100ml of deionized water were used as raw materials. Use gentle stirring to configure sodium alginate aqueous solution; mix the aqueous solution containing 0.4g silk fibroin with the prepared sodium alginate aqueous solution evenly to prepare silk fibroin-sodium alginate mixed solution, defoam and stand for backup use. The mixed solution is naturally spread on the glass plate by casting method, the solution thickness is 2mm, and the composite film is solidified with a calcium chloride aqueous solution with a mass fraction of 3%. The membrane shall prevail, and then be cleaned with deionized water until calcium chloride-free, and then dried naturally in a constant temperature and humidity chamber with a temperature of 50° C. and a relative ...

Embodiment 3

[0031] Same as Example 2, the difference is that the aqueous solution containing 0.6g silk fibroin is uniformly mixed with the prepared aqueous sodium alginate solution.

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Abstract

The invention discloses a method for preparing a silk fibroin-alginate composite film, and belongs to the fields of composite materials and biotechnology. According to the method, brown algae extracted marine biomass sodium alginate serving as a substrate is mixed with waste silkworm cocoon extracted high-molecular-weight silk fibroin-alginate to prepare the dual-component composite film through tape casting by adopting supramolecular self-assembly and ionic crosslinking processes. The silk fibroin-alginate composite film has more intermolecular hydrogen-bond interactions, the comprehensive mechanical performance of the film can be improved, the moistening, water absorption and moisture absorption performance of the composite film can be remarkably improved due to the special interpenetrating mesh structure, and possibility is provided to loading of other sustained-release substances. The composite film is prepared from natural and green raw materials, and integrates excellent biocompatibility, non-toxicity, biodegradability and other properties of silk fibroin and sodium alginate, and can be applied to the industry of beautifying and skin-protecting masks. The preparation method is simple in preparation process, realizes solution recycling, is environmentally friendly, and has an excellent application prospect.

Description

technical field [0001] The present invention relates to a silk fibroin film and a preparation method thereof, in particular to a high-strength loadable silk fibroin-alginate composite film and a preparation method thereof, and the present invention also relates to the silk fibroin-alginate The application of the composite film as a facial mask belongs to the field of composite materials and the field of biotechnology. Background technique [0002] With the rapid development of science and technology, the concept of low-carbon environmental protection has been deeply rooted in the hearts of the people, and human beings have attached great importance to the protection of the environment. Facing the increasingly scarce oil resources today, the chemical synthesis industry with high energy consumption and high pollution is facing enormous pressure. Looking for New green biomass materials have become the mainstream of development. [0003] Silk fibroin (SF) is the main component ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/64A61K8/02A61Q19/00
CPCA61K8/733A61K8/0212A61K8/64A61K2800/10A61Q19/00
Inventor 张鸿陈婷婷祝国富田海涛王婷玉
Owner DALIAN POLYTECHNIC UNIVERSITY
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