A kind of long-acting oxytetracycline injection and preparation method thereof

A long-acting oxytetracycline and injection technology, which can be applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the limitation of injection application due to the instability of oxytetracycline injection. and other problems to achieve the effect of enhancing the effective action time, high efficacy and enhancing stability

Active Publication Date: 2019-11-26
LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Injection is a commonly used dosage form. Compared with other dosage forms, injection has fast onset of action, accurate dosage, reliable effect, and is not affected by various factors in the gastrointestinal tract. Orally administered individuals and drugs that cannot be taken orally; however, the instability of oxytetracycline injection has brought great limitations to injection applications

Method used

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  • A kind of long-acting oxytetracycline injection and preparation method thereof
  • A kind of long-acting oxytetracycline injection and preparation method thereof
  • A kind of long-acting oxytetracycline injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0013] A long-acting oxytetracycline injection, each 100mL injection contains: oxytetracycline 18-22g, PEG-400 10-20mL, propylene glycol 15-30mL, sodium formaldehyde sulfoxylate 0.5-5g, MgCl 2 7-10g, cecropin antibacterial peptide 0.01-0.03g, ethanolamine 8-10mL, and the rest is water for injection.

[0014] The preparation method of the above-mentioned long-acting oxytetracycline injection comprises the following steps: take an appropriate amount of water for injection, add sodium formaldehyde sulfoxylate, magnesium chloride and stir to dissolve, add PEG-400, propylene glycol, stir and mix, add ethanolamine Adjust the pH to 7.0-9.0, fill with nitrogen to saturation, add injection-grade oxytetracycline, stir and moisten, heat the interlayer of the liquid mixing tank to keep the temperature of the Chinese medicine in the liquid mixing tank at 40°C-80°C, stir until it is completely dissolved and clear, and mix the liquid in the tank Fill the tank with nitrogen to saturate it al...

Embodiment 2

[0016] A long-acting oxytetracycline injection, each 100mL injection contains: oxytetracycline 20g, PEG-400 15mL, propylene glycol 22mL, sodium formaldehyde sulfoxylate 3g, MgCl 2 8.5g, cecropin antimicrobial peptide 0.02g, ethanolamine 9mL, and the rest is water for injection.

[0017] The preparation method of the above-mentioned long-acting oxytetracycline injection comprises the following steps: take an appropriate amount of water for injection, add sodium formaldehyde sulfoxylate, magnesium chloride and stir to dissolve, add PEG-400, propylene glycol, stir and mix, add ethanolamine Adjust the pH to 8.0, fill with nitrogen to saturation, add injection grade oxytetracycline and stir to moisten, heat the interlayer of the liquid mixing tank to keep the temperature of the Chinese medicine in the liquid mixing tank at 60°C, stir until it is completely dissolved and clear (nitrogen gas is always passed into the liquid mixing tank Saturation), stop heating the interlayer of the...

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Abstract

The invention discloses a long-acting oxytetracycline injection. Each 100mL of the injection consists of 18-22g of oxytetracycline, 10-20mL of PEG-400 (polyethylene glycol-400), 15-30mL of propylene glycol, 0.5-5g of sodium formaldehyde sulfoxylate, 7-10g of MgCl2, 0.01-0.03g of cecropin antibacterial peptide, 8-10mL of ethanolamine and the balance of injection water. The long-acting oxytetracycline injection provided by the invention, compared with a normal oxytetracycline injection, is produced by virtue of a rapid, low-temperature and high-efficiency complexation process, and the long-acting oxytetracycline injection is more stable in characters, low in toxicity, low in side effects, low in usage dosage, high in efficacy, rapid to take effects and long in acting duration.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug processing, and in particular relates to a long-acting oxytetracycline injection and a preparation method thereof. Background technique [0002] Oxytetracycline is a broad-spectrum tetracycline antibiotic, which has good curative effect on infections caused by gram-positive bacteria, gram-negative bacteria, mycoplasma, chlamydia, and rickettsia. [0003] Oxytetracycline is slightly soluble in water, soluble in methanol, ethanol, and propylene dione; it is relatively stable in the air, but its color tends to darken when exposed to light. However, no matter whether its preparation is under acidic or alkaline conditions, it is prone to darkening, precipitation, and potency reduction when it is heated or placed for a long time. This is because its aqueous solution decomposes through the forked isomerization reaction, dehydration reaction, hydrolysis reaction and oxidation reaction. Under acid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K9/08A61K47/10A61K47/52A61K47/20A61P31/04A61P37/04A61K31/65
CPCA61K9/0019A61K9/08A61K31/65A61K38/1767A61K47/10A61K47/20A61K2300/00
Inventor 郭文江吴保庆何涛常鹏艳刘扬科于恩琪
Owner LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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