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Method for preparing chitosan encapsulated nano-silver graphene oxide composite antibacterial material

A technology of graphene composite and antibacterial materials, which is applied in botany equipment and methods, fungicides, chemicals for biological control, etc., can solve problems such as threats to human health, restrictions, and high energy consumption, and achieve safe and reliable use , low energy consumption and simple preparation method

Inactive Publication Date: 2017-02-22
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the patent uses highly toxic glyoxylic acid as a reducing agent in the preparation process, which limits the application of medical materials and easily poses a threat to human health. At the same time, the long-term heating in the preparation process leads to excessive energy consumption.

Method used

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  • Method for preparing chitosan encapsulated nano-silver graphene oxide composite antibacterial material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Add 0.1%wt silver nitrate solution and 0.1%wt O-carboxymethyl chitosan solution into the stirrer at a volume ratio of 5:95, and stir at room temperature for 1h.

[0023] (2) Put the above mixed solution in a 4mL quartz cuvette, pass nitrogen gas for 20s to remove the air and seal it.

[0024] (3) Place the quartz cuvette at a distance of 5cm from a 272nm ultraviolet lamp and irradiate it for 15min with a power of 20w.

[0025] (4) Add one volume of absolute ethanol to the mixed solution, centrifuge at 14000r / min for 60min to collect the precipitate, and wash twice with 50%wt ethanol.

[0026] (5) The precipitate was dissolved in ultrapure water again, and ultrasonically treated for 10 minutes to obtain the O-carboxymethyl chitosan-coated nano-silver dispersion.

[0027] (6) Mix 0.1 mg / mL O-carboxymethyl chitosan-coated nano-silver dispersion with 0.1 mg / mL graphene oxide dispersion at a volume ratio of 5:1, and sonicate for 10 minutes to obtain O-carboxymethyl Chi...

Embodiment 2

[0034] According to the process of Example 1, the difference of Example 2 is that the O-carboxymethyl chitosan-wrapped nano-silver dispersion and the graphene oxide dispersion are in a volume ratio of 3:3.

[0035] Microbroth dilution method minimum inhibitory concentration test with embodiment 1.

[0036] The test results show that the O-carboxymethyl chitosan coated nano-silver graphene oxide composite antibacterial material in this example has a minimum inhibitory concentration of 4 µ / mL for Escherichia coli, and a minimum inhibitory concentration of 4 µ / mL for Staphylococcus aureus. mL.

Embodiment 3

[0038] According to the process of Example 1, the difference of Example 3 is that the O-carboxymethyl chitosan-wrapped nano-silver dispersion and the graphene oxide dispersion are in a volume ratio of 2:4.

[0039] Microbroth dilution method minimum inhibitory concentration test with embodiment 1.

[0040] The test results show that the O-carboxymethyl chitosan coated nano-silver graphene oxide composite antibacterial material in this example has a minimum inhibitory concentration of 0.25 µ / mL for Escherichia coli, and a minimum inhibitory concentration of 1 µ / mL for Staphylococcus aureus. mL.

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Abstract

The invention relates to a method for preparing a chitosan encapsulated nano-silver graphene oxide composite antibacterial material. The method comprises the steps of proportionally mixing a silver nitrate solution and an O-carboxymethyl chitosan solution, then, carrying out ultraviolet irradiation so as to prepare an O-carboxymethyl chitosan encapsulated nano-silver antibacterial agent, and carrying out self-assembly on purified O-carboxymethyl chitosan encapsulated nano-silver particles and graphene oxide in an aqueous solution, thereby preparing the O-carboxymethyl chitosan encapsulated nano-silver graphene oxide composite antibacterial material. According to the method, O-carboxymethyl chitosan and the graphene oxide serve as an auxiliary antibacterial agent and a stabilizer, so that the re-adding of chemical reagents is avoided, and the toxicity of the antibacterial agent is lowered. Under ultraviolet irradiation, Ag ions are reduced to elemental silver, O-carboxymethyl is adsorbed to the surface of silver cores, and silver nanoparticles are adsorbed to the surface of the graphene oxide after self-assembly, so that a synergistic antibacterial action is exerted; and the used materials are harmless to human bodies and are low in price, so that the method is an environment-friendly novel composite antibacterial agent preparation method.

Description

technical field [0001] The present invention relates to a preparation method of a graphene oxide-nano-silver composite antibacterial agent, in particular to a preparation method in which O-carboxymethyl chitosan-wrapped nano-silver is evenly loaded on the surface of graphene oxide by self-assembly in an aqueous solution . Background technique [0002] The use of antibacterial agents to inhibit and kill harmful bacteria is an important method to improve human health. Traditional antibacterial agents, such as antibiotics and quaternary ammonium salts, will not only lead to drug resistance of microorganisms, but also cause serious environmental pollution. Nano-silver has been gradually used in biomedicine and clinical fields due to its good broad-spectrum antibacterial properties and low drug resistance. However, nano-silver has the characteristics of easy agglomeration, easy oxidation and poor water solubility, which limits its further application. Graphene oxide is a quasi-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N59/16A01P1/00A01P3/00
CPCA01N25/08A01N59/16
Inventor 魏丽乔牛宝龙张杰管路遥马森源刘日宏
Owner TAIYUAN UNIV OF TECH
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