Composite cefquinome microsphere gel preparation and preparation method thereof
A technology of cefquinome and compound preparations, which is applied in the field of cefquinome microsphere gel compound preparations and its preparation, can solve the problems of personnel and drug waste, reduce the frequency of administration, etc., and achieve improved drug efficacy, reduced exposure, and prolonged The effect of entry time
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Embodiment 1
[0031] The cefquinome microsphere gel composite preparation of the present invention is prepared by weight from the following raw materials:
[0032]
[0033] Preparation method:
[0034] 1. Take polylactic acid-glycolic acid copolymer, add it to ethyl acetate, then add 100g of cefquinome micropowder, shear and stir to form a uniform suspension, at an inlet temperature of 40°C, a feed rate of 100ml / h, Under the conditions of pressure 0.4MPa and power 20Hz, carry out spray drying to obtain microsphere powder for future use;
[0035] 2. Take 3g of sodium hyaluronate (molecular weight: 2 million), add 900g of water for injection, make it infiltrate and swell to form a transparent gel matrix, mix the gel matrix and microsphere powder, and stir until uniform.
Embodiment 2
[0037] The veterinary cefquinoxime microsphere gel composite preparation of the present invention is prepared by weight from the following raw materials:
[0038]
[0039]
[0040] Preparation method:
[0041] 1. Take polylactic acid-glycolic acid copolymer, add it to acetone, then add 100g of cefquinome micropowder, and shear and stir to form a uniform suspension. Carry out spray drying under KPa, power 40Hz parameter condition, obtain microsphere powder, standby;
[0042] 2. Take 10g of sodium hyaluronate (molecular weight: 1,000,000), add 900g of water for injection, and make it infiltrate and swell to form a transparent gel matrix. Mix the gel base and the microsphere powder, stir until uniform, and obtain.
Embodiment 3
[0044] The veterinary cefquinoxime microsphere gel composite preparation of the present invention is prepared by weight from the following raw materials:
[0045]
[0046] Preparation method:
[0047] 1. Take polylactic acid-glycolic acid copolymer, add it to chloroform, then add 100g of cefquinome micropowder, and shear and stir to form a uniform suspension. Carry out spray drying under KPa, power 30Hz parameter condition, obtain microsphere powder, standby;
[0048] 2. Take 90g of sodium hyaluronate (molecular weight: 100,000) and add 900g of water to make it infiltrate and swell into a transparent gel matrix. Mix the gel base and the microsphere powder, stir until uniform, and obtain.
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