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External used medicine for curing physical skin diseases and animal skin diseases and preparation method and application thereof

A technology of externally applied drugs and therapeutic drugs, applied in the direction of skin diseases, medical raw materials derived from mammals, drug combinations, etc., can solve problems such as side effects and unsatisfactory curative effects, and achieve the effect of eliminating inflammation, non-toxic side effects, and preventing pimples

Inactive Publication Date: 2017-03-15
SHANGHAI MINGDA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the deficiencies of the prior art, to provide a kind of medicine for external use and its preparation method for the treatment of physical skin diseases and animal skin diseases, to solve the technical problems such as the unsatisfactory curative effect of the existing medicines and the existence of side effects

Method used

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  • External used medicine for curing physical skin diseases and animal skin diseases and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Material:

[0031] The methods used in this embodiment are conventional methods known to those skilled in the art unless otherwise specified, and the reagents and other materials used, unless otherwise specified, are all commercially available products.

[0032] 2. Method

[0033] 2.1 Preparation of NK cell stock solution

[0034] Step 1: PBMC extraction:

[0035] Centrifuge the fresh blood at 740g for 10 minutes to obtain the upper layer of light yellow plasma and the lower layer of blood cells. Mix the lower layer of blood cells with saline in a volume ratio of 1:1, take a 50ml centrifuge tube, and spread the diluted blood cell suspension on 15ml of lymphocyte separation solution Centrifuge at 400g for 30 minutes. The middle white membranous cell layer was collected, washed with physiological saline, centrifuged at 400g for 10 minutes, the supernatant was discarded, and the washing was repeated once. Finally, resuspend the cell pellet with an appropriate amount of culture...

Embodiment 2

[0067] This embodiment provides a SNK solution, by weight, the SNK solution consists of 80.0% of NK cell stock solution, 5.0% of glycerin, 0.08% of borax, 0.3% of hyaluronic acid, 0.03% of ethyl p-hydroxybenzoate, and an appropriate amount of water. The composition, wherein the preparation method of the NK cell stock solution is the same as in Example 1.

[0068] Selected 5 cases of prickly heat patients and 2 cases of mild burn patients, treated with the above-mentioned SNK liquid, used 2-3 times a day, and found that the above-mentioned SNK liquid has a significant therapeutic effect on heat rash and mild burns, and the patients with mild heat rash continuously It can be cured in 2 days, severe heat rash patients can be cured in 4 consecutive days, and mild burns can be cured in 3 days.

Embodiment 3

[0070] This embodiment provides a SNK cream, by weight, the SNK cream is composed of 70.0-80.0% of NK cell stock solution, 0.1-1.5% of carbomer 941, 1.0-2.0% of glycerol, 1.0-3.0% of triethanolamine, It is composed of 0.01-0.03% ethyl paraben, 0.05-0.1% hyaluronic acid and a proper amount of water.

[0071] Six patients with mosquito bites and 3 patients with summer dermatitis were selected for treatment with the above-mentioned SNK cream. The results showed that the above-mentioned SNK cream has a significant therapeutic effect on mosquito bites and summer dermatitis. Generally, patients with mosquito bites can be cured after 3 days of application. Pigment is retained, and patients with summer dermatitis are cured after 6 days of continuous use.

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Abstract

The invention discloses an external used medicine for curing physical skin diseases and animal skin diseases, and a preparation method and application of the external used medicine. The main ingredient of the external used medicine is an NK cell stock solution, the NK cell stock solution is obtained through multiplication culture of an NK cell, and the NK cell stock solution is mixed with different pharmaceutical materials to prepare an external used liquid preparation or an external used cream preparation. Compared with the prior art, the external used medicine for curing physical skin diseases and animal skin diseases uses a cell factor excreted by the NK cell to diminish inflammation, prevents mosquito bite and infections of fungus and bacteria caused by papule, vesicle, wounds and anabrosis, has the advantages of stopping itching rapidly, curing thoroughly and having no toxic or side effects, etc., is particularly suitable for people with sensitive skin, infants, pregnant women and the like, and is also suitable for special crowds unsuitable for other medicines or hormone.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an external medicine for treating physical skin diseases and animal skin diseases, and a preparation method and application thereof. Background technique [0002] Physical skin diseases refer to adverse reactions caused by various physical factors (mechanical friction, temperature, humidity, light, electromagnetic radiation waves, pressure, etc.) acting on the skin. Skin trauma is an injury that people often encounter in daily life. The skin healing process is slow, and if it is not handled properly, infection and ulceration may occur and it is difficult to cure. [0003] Summer dermatitis is a frequent occurrence in summer, due to the continuous high temperature and high humidity of the external environment, and the skin is sweaty and not cleaned in time. Occurs in middle-aged and obese women. The typical symptoms are dense erythema, papules or papules and blisters on the extended sides...

Claims

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Application Information

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IPC IPC(8): A61K35/17A61K9/06A61P17/00A61P17/02A61P31/10A61P31/04A61P17/04
Inventor 李祥宇卢玲琳王苏鸣
Owner SHANGHAI MINGDA BIOTECH CO LTD
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