Double-chamber bag amino acid peritoneal dialysis solution and preparation method thereof

Abstract

The invention relates to the field of blood purification, particularly relates to a dual-chamber bag amino acid peritoneal dialysis solution and a preparation method thereof. The dual-chamber bag amino acid peritoneal dialysis solution comprises a first chamber bag and a second chamber bag, wherein the volume ratio of the first chamber to the second chamber is 2.5:7.5 to 4.5:5.5. The first chamber contains amino acid and electrolyte, the total amount of the amino acid is 7.8-14.2 g / L, and the pH is 4.0-7.0. The second chamber contains a buffer solution containing acids such as organic acids, inorganic acids, analogues and their combinations and with the pH of 8.0-9.0. The liquid in the first chamber and the liquid in the second liquid can be mixed into a solution with the pH of 6.5 to 7.5 before the liquid is injected into a patient. The dialysis solution conforms to the physiology of a human body, and abdominal pain caused by slightly lower or higher pH in the peritoneal dialysis process is relieved. In addition, by introducing bicarbonate, the lactate content in a formula is reduced, and accordingly the risk of acidosis exacerbation of the patient is reduced.

Description

technical field [0001] The invention relates to the field of blood purification, in particular to a double-chamber bag amino acid peritoneal dialysis solution and a preparation method thereof. Background technique [0002] Peritoneal dialysis (PD) is an effective method for treating uremia. Peritoneal dialysis uses the peritoneum as a dialysis membrane to inject dialysate into the peritoneal cavity. The plasma in the capillaries on one side of the peritoneum and the dialysate on the other side are used Its solute concentration gradient and osmotic gradient, through the principles of dispersion and ultrafiltration, remove the metabolic waste and excess water retained in the body, and at the same time replenish the necessary substances through the dialysate. Constant replacement of fresh dialysate and repeated dialysis can achieve the therapeutic purpose of removing toxins, removing excess water, and correcting acidosis and electrolyte imbalance. [0003] At present, there ar...

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Problems solved by technology

Lactate dialysate formula has finished products. Lactic acid consists of two isomers, D and L. L-form lactic acid is prone to buffering effect, has a relatively long validity period, stable properties, wide application, convenient use and low price, and has obvious clinical advantages. However, some scholars have suggested that after lactic acid enters the human body, it needs to be metabolized into carbonic acid by the liver. When the liver enzyme molecule lactic acid is converted into carbonic acid, 3 molecules of oxygen are needed, and the original acidosis degree of some patients will increase.

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