Epoxy type annonaceous acetogenin compound with antitumor activity and preparation method and application thereof

An annua lactone and anti-tumor activity technology, applied in the field of medicine, can solve the problems of large toxic and side effects, high price, limited anti-tumor activity, etc., and achieve the effect of strong anti-tumor activity and low toxicity
CN106543159AInactive Publication Date: 2017-03-29NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2017-03-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an epoxy type annonaceous acetogenin compound with antitumor activity; through systematic deep research on the chemical composition of Annona squamosa seeds, wave spectral and mass spectral data analysis indicates the novel epoxy annonaceous acetogenin compound is isolated from Annona squamosa seeds, in-vivo and in-vitro antitumor activity researches indicate that epoxy type annonaceous acetogenins provided herein show high antitumor activity to various tumor cells, such as lung cancer cells, breast cancer cells, and liver cancer cells and show significant inhibitory activity to the solid tumors of mouse implanted hepatic tumor HepG2 and mouse sarcoma S180, and toxicity experiment researches indicate that the epoxy type annonaceous acetogenin compound provided herein has low toxicity and is a good antitumor compound.
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Description

technical field

[0001] The invention relates to a compound with anti-tumor activity, in particular to a novel epoxy type annona lactone compound with anti-tumor activity and its application in preventing and treating tumor diseases, belonging to the technical field of medicine. Background technique

[0002] Malignant tumors are frequent and common diseases that seriously endanger human health and life. As early as 2000-3000 years ago, there were records about tumors in Egypt and my country. In many countries including China, especially moderately developed countries, the death caused by malignant tumors accounts for the first or second place among all causes of death, and the incidence rate is still on the rise worldwide. Among the four major therapies of chemotherapy, chemotherapy, and biological therapy, chemotherapy is still the main treatment method, but as we all know, the existing chemotherapy drugs have limited anti-tumor activity, large toxic and side effects, poor p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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