Preparation and application of ganoderma lucidum spore oil, ganoderma lucidum spore oil fat emulsion

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum spore powder, which is applied in the directions of fat oil/fat production, fat production, emulsion transportation, etc., can solve problems such as loss of functional components, and achieve the effect of improving liver function and improving anti-tumor activity.

Inactive Publication Date: 2017-05-24
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The spore oil obtained by most of the Ganoderma lucidum spore oil separation process on the market needs to go through conventional refining processes such as deacidification and deodorization to obtain Ganoderma lucidum spore oil that meets the edible oil hygiene standards, and the refining process will make the unique triterpene acids in the product , ergosterol, fat-soluble vitamins and other functional components loss

Method used

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  • Preparation and application of ganoderma lucidum spore oil, ganoderma lucidum spore oil fat emulsion
  • Preparation and application of ganoderma lucidum spore oil, ganoderma lucidum spore oil fat emulsion
  • Preparation and application of ganoderma lucidum spore oil, ganoderma lucidum spore oil fat emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 Ganoderma lucidum spore oil

[0055] The preparation process of the present embodiment Ganoderma lucidum spore oil is as follows:

[0056] Step 1 break the wall

[0057] The Ganoderma lucidum spore powder of the present embodiment adopts commercially available Ganoderma lucidum spore powder, and the moisture of this commercially available Ganoderma lucidum spore powder≤8.0%, ash content≤3.0%, acid value (calculated as fat)≤10mg / g, peroxide value (in terms of fat) Fat meter) ≤ 0.25g / 100g;

[0058] Put the Ganoderma lucidum spore powder in the material box of the Bailey micronizer, set the wall breaking time to 55 minutes, and the wall breaking temperature to -14°C to obtain the broken wall Ganoderma lucidum spore powder;

[0059] Step 2 Granulation

[0060] Weigh 60kg of the broken Ganoderma lucidum spore powder prepared in step 1 and add it to the CH-200 tank mixer, and add the mass percentage concentration 95% ethanol, cover, stir and mix for 20 minute...

Embodiment 2

[0066] Embodiment 2 Ganoderma lucidum spore oil

[0067] The preparation process of the present embodiment Ganoderma lucidum spore oil is as follows:

[0068] Step 1 break the wall

[0069] The Ganoderma lucidum spore powder of the present embodiment adopts commercially available Ganoderma lucidum spore powder, and the moisture of this commercially available Ganoderma lucidum spore powder≤8.0%, ash content≤3.0%, acid value (calculated as fat)≤10mg / g, peroxide value (in terms of fat) Fat meter) ≤ 0.25g / 100g;

[0070] Put the Ganoderma lucidum spore powder in the material box of the Bailey micronizer, set the wall breaking time to 70 minutes, and the wall breaking temperature to -16°C to obtain the broken wall Ganoderma lucidum spore powder;

[0071] Step 2 Granulation

[0072] Weigh 60kg of broken ganoderma lucidum spore powder and add it to CH-200 tank mixer, according to the weight ratio of broken ganoderma lucidum spore powder: ethanol=5:3.5, add mass percentage concentra...

Embodiment 3

[0078] Example 3 Ganoderma lucidum spore oil functional experiment

[0079] In this example, the antitumor function of the Ganoderma lucidum spore oil prepared in Example 1 was experimentally studied.

[0080] 1. Cell lines and experimental animals

[0081] Cell line: Liver cancer H22 cell line, provided and revived by the Cell Bank of the Experimental Animal Center of Sun Yat-sen University.

[0082] Experimental animals: SPF grade BALB / C nude mice, 5-6W, male, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine.

[0083] 2. The present embodiment is divided into 8 experimental groups; the dosage, concentration and route of administration of each group are specifically as follows:

[0084] (1) Control group: normal saline, 0.2ml / 10g mice, injected into the tail vein once a day;

[0085] (2) Ganoderma lucidum spore polysaccharide oral group: Ganoderma lucidum spore polysaccharide (water extract of Ganoderma lucidum sporopollen)...

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Abstract

The invention discloses a preparation and application of ganoderma lucidum spore oil, ganoderma lucidum spore oil fat emulsion. The ganoderma lucidum spore oil is obtained by being directly prepared by two stage separation after wall-breaking, granulation, drying and supercritical CO2 extraction of the ganoderma lucidum spore. Conventional refining processes including deacidification and deodorization are not needed. The ganoderma lucidum spore oil is rich in monounsaturated fatty acid mainly comprising oleic acid, keeps the functional components of triterpene acid, ergosterol and fat-soluble vitamin peculiar to ganoderma lucidum and has good antitumor activity. Hygienic indexes of product acid value, peroxide value and the like meet cooking oil hygienic standards. The fat emulsion prepared from ganoderma lucidum spore oil by homogenization technique is convenient to take and has good effects of antitumor and effect-enhancing and toxicity-reducing, and active ingredients are more beneficial for human body absorption, and the bioavailability is high.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the preparation technology of ganoderma lucidum spore oil and its fat emulsion, and in particular to the application of ganoderma lucidum spore oil and its fat emulsion in antitumor. Background technique [0002] Ganoderma lucidium spores are extremely small spores ejected from the cap during the growth and maturity stage of Ganoderma lucidum. They are the reproductive cells of Ganoderma lucidum and have all the genetically active substances of Ganoderma lucidum. Modern pharmacological studies have shown that Ganoderma lucidum spores have the functions of anti-tumor, enhancing immune regulation, anti-virus, lowering blood sugar, lowering blood fat, anti-hypoxia, anti-inflammation, and scavenging free radicals. The chemical composition of Ganoderma lucidum and Ganoderma lucidum spores is complex and has a wide range of biological activities. Among them, polysa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/107A61K47/24A61P35/00C11B1/10C11B1/04
Inventor 李菁袁诚罗爱勤陈路林蒋兆健王小妹陈亮
Owner GUANGZHOU HANFANG PHARMA
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