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A separating column used for purification and copper removing

A separation column and column technology, applied in the field of separation columns, can solve the problems of separation columns without copper ions, blockage of chromatographic columns, etc., and achieve the effects of large capacity, ensuring mechanical strength, and stable chemical properties.

Inactive Publication Date: 2017-06-06
SHANGHAI ATOM KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the purification of radiopharmaceuticals is generally separated and purified by high performance liquid phase products, and too much copper salt will block the chromatographic column
However, there is currently no separation column specifically designed to remove copper ions

Method used

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  • A separating column used for purification and copper removing
  • A separating column used for purification and copper removing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Such as figure 1 or figure 2 As shown, a separation column for purifying and removing copper includes a column body 2, a head 5 and an ion exchange resin 6. The column body 2 is a hollow cylindrical column body, and its upper end is provided with a standard interface for inserting a syringe. The upper end of the head 5 is inserted into the cavity at the lower end of the column body 2 and fixedly connected with the column body 2 , and the ion exchange resin 6 is filled into the cavity of the column body 2 . Wherein said cylinder 2 is a polytetrafluoroethylene cylinder.

[0028] The separation column also includes a detachable upper sieve plate 1 and a lower sieve plate 3 arranged in the cavity of the column body 2, the upper sieve plate 1 is in contact with the lower end surface of the standard interface, and the lower sieve plate 3 is in contact with the lower end surface of the standard interface. The sieve plate 3 is in contact with the upper surface of the head 5 ...

Embodiment 2

[0030] Such as figure 1 or figure 2 As shown, a separation column for purifying and removing copper includes a column body 2, a head 5 and an ion exchange resin 6. The column body 2 is a hollow cylindrical column body, and its upper end is provided with a standard interface for inserting a syringe. The upper end of the head 5 is inserted into the cavity at the lower end of the column body 2 and fixedly connected with the column body 2 , and the ion exchange resin 6 is filled into the cavity of the column body 2 . Wherein said cylinder 2 is a polytetrafluoroethylene cylinder.

[0031] The separation column also includes a detachable upper sieve plate 1 and a lower sieve plate 3 arranged in the cavity of the column body 2, the upper sieve plate 1 is in contact with the lower end surface of the standard interface, and the lower sieve plate 3 is in contact with the lower end surface of the standard interface. The sieve plate 3 is in contact with the upper surface of the head 5 ...

Embodiment 3

[0033] Such as figure 1 or figure 2 As shown, a separation column for purifying and removing copper includes a column body 2, a head 5 and an ion exchange resin 6. The column body 2 is a hollow cylindrical column body, and its upper end is provided with a standard interface for inserting a syringe. The upper end of the head 5 is inserted into the cavity at the lower end of the column body 2 and fixedly connected with the column body 2 , and the ion exchange resin 6 is filled into the cavity of the column body 2 . Wherein said cylinder 2 is a polytetrafluoroethylene cylinder.

[0034] The separation column also includes a detachable upper sieve plate 1 and a lower sieve plate 3 arranged in the cavity of the column body 2, the upper sieve plate 1 is in contact with the lower end surface of the standard interface, and the lower sieve plate 3 is in contact with the lower end surface of the standard interface. The sieve plate 3 is in contact with the upper surface of the head 5 ...

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Abstract

The invention relates to a separating column used for purification and copper removing. The separating column is characterized in that the separating column includes a column body (2), an end socket (5) and ion exchange resin (6); the column body (2) is a hollow cylinder; the upper end of the column body is provided with a standard connector for injector insertion; the upper end of the end socket (5) is inserted into a lower-end cavity of the column body (2) and is fixedly connected to the column body (2); and the ion exchange resin (6) fills the cavity of the column body (2). Compared with the prior art, the separating column has advantages of a high capacity, good selectivity, high mechanical strength, stable chemical performance, a high copper ion removing rate, and the like.

Description

technical field [0001] The invention relates to a separation column, in particular to a separation column for purifying and removing copper. Background technique [0002] Some radiopharmaceuticals use copper as a catalyst in the preparation process, especially the 1,3-dipolar cycloaddition reaction of azide and terminal alkyne, which has been widely studied. In humans, copper is cytotoxic, causing oxidative degradation of DNA and proteins through the formation of hydroxyl radicals. Excessive copper can stimulate the digestive system and cause symptoms of gastrointestinal poisoning, such as abdominal pain, nausea, vomiting, or diarrhea. In severe cases, gastrointestinal mucosal ulcers, hemolysis, liver necrosis, renal failure, and even death from shock may occur. Skin necrosis can occur upon exposure to high concentrations of copper compounds. Therefore, drugs prepared by copper catalysis must remove excess copper ions before being applied to the human body. At the same ti...

Claims

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Application Information

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IPC IPC(8): B01D15/22B01D15/36
Inventor 贾丽娜
Owner SHANGHAI ATOM KEXING PHARMA
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