Babesia microti thioredoxin reductase molecule, and gene and applications thereof

A technology of babesia thioredoxin and thioredoxin, applied in the field of bioengineering
CN106801042AInactive Publication Date: 2017-06-06SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
Publication Date
2017-06-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an amino acid sequence of a babesia microti thioredoxin reductase molecule. The invention also discloses a gene of the babesia microti thioredoxin reductase molecule, and the gene includes a nucleotide sequence encoding the amino acid sequence shown as SEQ ID NO.1. The babesia microti thioredoxin reductase molecule has good reduction activity for DTNB, insulin, a substrate BmiTrx and direct-line homologous protein EcoTrx, and is suitable for screening a BmiTrx inhibitor medicine treating babesiosis.
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Description

technical field

[0001] The invention relates to the technical field of bioengineering, in particular to a Babesia microti thioredoxin reductase molecule and its gene and application. Background technique

[0002] Babesia microti is a new zoonotic protozoan disease transmitted by ticks. It parasitizes in the red blood cells of human and rodent hosts, causing symptoms such as fever, anemia, and systemic exhaustion. The elderly, The infection is most severe and can lead to death in patients who have had their spleens removed or who are immunocompromised. Since the first case of human infection with Babesia microti was detected in California, USA in 1969, thousands of cases of human infection have been reported, and there is an increasing trend in recent years. Babesia vole is mainly prevalent in the United States and some European countries, and has been reported in other parts of the world, such as Japan, South Korea, South Africa, Brazil, India and other countries and Taiwan...

Claims

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