High-ultraviolet absorption lignin/chemical sunscreen agent microcapsule and preparation method thereof

一种化学防晒剂、木质素的技术，应用在微胶囊制剂、微球制备、化妆品配制品等方向，能够解决增加制备和分离成本、伤害等问题，达到成本低、制备过程简单、巨大应用前景的效果

Active Publication Date: 2017-06-16
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether it is chitosan, liposome, or polylactic acid-polyglycerol synthesized by multiple steps, although chemical sunscreen agents can be embedded through chemical cross-linking, various auxiliary agents such as emulsifiers and cross-linking agents need to be added. The addition of additives not only increases the cost of preparation and separation, but also considers the damage of additive residues to human body and skin
At the same time, the embedding and retention performance of the above wall materials for chemical sunscreens needs to be further evaluated

Method used

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  • High-ultraviolet absorption lignin/chemical sunscreen agent microcapsule and preparation method thereof
  • High-ultraviolet absorption lignin/chemical sunscreen agent microcapsule and preparation method thereof
  • High-ultraviolet absorption lignin/chemical sunscreen agent microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Put 20g of solvent-based lignin in a 500mL beaker, add 180g of aqueous solution of pH 12 to dissolve the lignin, then add dilute hydrochloric acid to adjust the pH of the solution to 8.5, filter out the insoluble matter, and obtain a solvent-based lignin with a mass fraction of 10%. plain water solution.

[0040] (2) 100g of the lignin solution obtained in step (1) and 100g of the chemical sunscreen homosalate were added to the medium, the water-oil ratio was 1:1, and the ultrasonic radiation treatment of 600W power was used for 3min to obtain lignin-containing / Homosalate microcapsule emulsion.

[0041] (3) The emulsion obtained in step (2) was centrifuged and washed for 20 minutes at a speed of 10000 r / min to obtain a lignin / homosalate microcapsule paste. figure 1 It is an optical microscope picture of the lignin / homosalate microcapsules of the product of Example 1 observed by an optical microscope, showing that the microcapsules are spherical structures with a ...

Embodiment 2

[0045] (1) Put 6g of enzymolytic lignin in a 500mL beaker, add 194g of pH12 aqueous solution to dissolve lignin, then add dilute hydrochloric acid to adjust the pH of the solution to 9.5, filter out insolubles, and obtain enzymatic lignin with a mass fraction of 3%. plain water solution.

[0046] (2) 50 g of the lignin solution obtained in step (1) and 5 g of the chemical sunscreen agent isooctyl methoxycinnamate are put into the medium, the water-oil ratio is 10:1, and the ultrasonic radiation of 1000W power is used for 30 seconds, A microcapsule emulsion containing lignin / isooctyl methoxycinnamate was obtained.

[0047] (3) The emulsion obtained in step (2) was centrifuged and washed for 10 min at a speed of 10000 r / min to obtain lignin / isooctyl methoxycinnamate microcapsule paste.

[0048] (4) Adopt optical microscope measurement, slow-release analysis, ultraviolet spectrum measurement identical with embodiment 1, the result is respectively with figure 1 , figure 2 , ...

Embodiment 3

[0050] (1) Put 10g of alkali lignin in a 500mL beaker, add 190g of an aqueous solution of pH 12 to dissolve the lignin, then add dilute hydrochloric acid to adjust the pH of the solution to 9.0, filter out the insoluble matter, and obtain an aqueous solution of alkali lignin with a mass fraction of 5% .

[0051] (2) Add 50 g of the lignin solution obtained in step (1) and 25 g of the chemical sunscreen agent homosalate and avobenzone into the mixture, the water-oil ratio is 2:1, and use 800W power ultrasonic ultrasonic radiation treatment 2min to obtain chemical sunscreen microcapsule emulsion containing lignin / (homosalate and avobenzone).

[0052] (3) The emulsion obtained in step (2) was centrifuged and washed for 10 minutes at a speed of 10000 r / min to obtain a lignin / chemical sunscreen agent microcapsule paste.

[0053] (4) Adopt optical microscope measurement, slow-release analysis, ultraviolet spectrum measurement identical with embodiment 1, the result is respectively ...

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Abstract

The invention belongs to the technical field of the preparation of chemical sunscreen agents, and discloses a high-ultraviolet absorption lignin / chemical sunscreen agent microcapsule adopting lignin as a wall material, and a preparation method thereof. The method comprises the following steps: 1, dissolving 1-20 parts by weight of lignin in 100-200 parts by weight of an aqueous solution with the pH value of 12, adjusting the pH value of the obtained solution to 7-10, and filtering out insoluble substances to obtain a lignin solution; and 2, mixing 10-50 parts by weight of the lignin solution obtained in step 1 with 1-10 parts by weight of a chemical sunscreen agent, and carrying out ultrasonic radiation under a power of 200-1500 W for 10 s to 5 min in order to obtain a lignin / chemical sunscreen agent microcapsule emulsion. The lignin / chemical sunscreen agent microcapsule has the advantages of excellent ultraviolet absorption performance, avoiding of light degradation of the chemical sunscreen agent, good stability, effective avoiding of direct contact and damages of the chemical sunscreen agent to skins, and great application prospect in the field of sunscreen and skincare products.

Description

technical field [0001] The invention belongs to the technical field of chemical sunscreen preparation, in particular to a high ultraviolet absorption lignin / chemical sunscreen microcapsule prepared by using lignin as a wall material and a preparation method. Background technique [0002] Sun exposure is one of the important factors that make the skin age, and strong ultraviolet radiation may cause skin cancer. Studies have shown that ultraviolet rays in the UVB band (290-320nm) can pass through the stratum corneum and epidermis, causing skin erythema and DNA damage, and ultraviolet rays in the UVA band (320-400nm) can reach the dermis, which is an important factor that causes melanoma. Therefore, effective sun protection is very necessary. Sunscreens can effectively absorb or scatter ultraviolet rays in the UVB and UVA bands of sunlight, and are generally divided into two categories: physical and chemical. Physical sunscreens such as titanium dioxide and zinc oxide and oth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/11A61K8/97A61Q17/04
CPCA61Q17/04A61K8/11A61K8/97A61K2800/412A61K8/72B01J13/14A61K8/9794A61K8/9789A61K8/35A61K8/37B01J13/185
Inventor 邱学青钱勇李莹杨东杰楼宏铭朱世平刘伟峰
Owner SOUTH CHINA UNIV OF TECH
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