Applications of chiral polymer catalyst in asymmetric reaction

Abstract

The invention discloses applications of a chiral polymer catalyst in asymmetric reaction, and belongs to the field of material synthesis and application. The phosphine-containing polymer is obtained via mixed polymerization of vinyl-containing chiral bidentate phosphine ligand BINAP (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) and derivative of vinyl-containing chiral bidentate phosphine ligand BINAP (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) with other vinyl comonomers. The vinyl polymer possesses relatively large specific surface area and porosity, and excellent thermal stability and chemical stability. In the heterogeneous catalyst, one or a plurality of elements selected from Ru, Rh, Ir, Pa, Au, and Cu are taken as active ingredients. The chiral ligand is uniformly embedded into and highly dispersed in a polymer skeleton, so that metal dispersion degree on the catalyst is relatively high, and relatively high catalytic activity is achieved. The heterogeneous catalyst is suitable for a plurality of reaction technology including intermittent still reaction, continuous fixed bed reaction, and trickle bed reaction. When the heterogeneous catalyst is used in catalytic kettle-type asymmetric hydrogenation, high target product yield is achieved, and enantioselectivity is higher than 96%.

Description

technical field [0001] The invention belongs to the field of heterogeneous catalysis, and is suitable for the preparation method of heterogeneous catalysts of chiral phosphine-containing organic polymers loaded with metals which are suitable for catalyzing the asymmetric hydrogenation reaction of β-keto esters. Background technique [0002] Asymmetric hydrogenation of unsaturated compounds containing carbon-carbon double bonds (C=C), carbon-oxygen double bonds (C=O) and carbon-nitrogen double bonds (C=N) with hydrogen molecules catalyzed by transition metal complexes Reaction is an important method for the synthesis of optically active compounds. This method is highly efficient, highly atom-economical, and environmentally friendly. After more than 40 years of development, asymmetric catalytic hydrogenation has been successfully applied to various types of chiral amino acids, chiral alcohols, chiral amines, and chiral carboxylic acids. Asymmetric Synthesis of Sexual Compound...

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Problems solved by technology

[0006] In view of the above defects and improvement needs of the prior art, the present invention provides a preparation method and application of a chiral porous polymer, the purpose of which is to improve the catalytic activity and stability of heterogeneous asymmetric reactions by optimizing the synthesis raw materials and processes , in order to solve the problems of difficult recovery of existing homogeneous asymmetric reaction catalysts and low activity of heterogeneous asymmetric reaction catalysts

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