Hydrogel with multiple response functions and its preparation method and use

A multi-response, hydrogel technology, used in the field of biomedical materials to achieve excellent mechanical properties, biocompatibility, and easy molding

Active Publication Date: 2019-04-05
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the defect that the existing hydrogel can only respond to a single external stimulus, the primary purpose of the present invention is to provide a method for preparing a hydrogel with multiple response functions

Method used

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  • Hydrogel with multiple response functions and its preparation method and use
  • Hydrogel with multiple response functions and its preparation method and use
  • Hydrogel with multiple response functions and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of the hydrogel material includes the following steps:

[0048] (1) Preparation of modified hydrogel material: 12.6g Pluronic F-127 was dissolved in 100mL of a mixed solution of dichloromethane:acetone=1:1 by volume, and 3mL of acryloyl chloride and 3mL of trichloride were added dropwise under ice bath. Ethylamine, ice bath for 12h, normal temperature for 12h. After the reaction, it was washed with saturated sodium bicarbonate solution, rotary evaporated and dried in vacuum at 40°C for 24h to obtain modified F-127 (12g).

[0049] (2) Preparation of modified selenium: After synthesizing the product of selenium diol according to the literature, take 1 g of selenium diol and dissolve it in 50 mL of dichloromethane solution, pour nitrogen gas into the reaction system for half an hour, and then take an ice bath 6mL of acryloyl chloride and 7mL of triethylamine were added dropwise, and reacted in an ice bath for 3h and at room temperature for 3h. After the reacti...

Embodiment 2

[0052] Preparation of hydrogel materials

[0053] In the step (3) of Example 1, "dissolve 10g of modified diselenide material and 10g of photopolymerization initiator in 100mL of vinylpyrrolidone solution" is amended to "compare 20g of modified diselenide material and 10g of The photopolymerization initiator was dissolved in 100 mL of vinylpyrrolidone solution", and the rest were the same as in Example 1. At this time, in the final mixed solution, the mass ratio of modified double selenium material and modified F-127 is 1:10.

Embodiment 3

[0055] Preparation of hydrogel materials

[0056] In the step (3) of Example 1, "dissolve 10g of modified diselenide material and 10g of photopolymerization initiator in 100mL of vinylpyrrolidone solution" is amended to "compare 30g of modified diselenide material and 10g of The photopolymerization initiator was dissolved in 100 mL of vinylpyrrolidone solution", and the rest were the same as in Example 1. At this time, in the final mixed solution, the mass ratio of modified double selenium material and modified F-127 is 3:20.

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Abstract

The invention discloses hydrogel with multiple response function and a preparation method and application thereof; the preparation method of the hydrogel comprises the steps of adding hydrogel material, acryloyl chloride and triethylamine into a solvent, and reacting under ice bath to obtain modified hydrogel material; adding diselenide-diol, acryloyl chloride and triethylamine into a solvent, reacting under ice bath to obtain modified diselenide with C-C double bond; mixing the modified hydrogel material solution with the modified diselenide solution, adding a photo-polymerization initiator, and irradiating in ultraviolet at 20-40 DEG C to generate hydrogel having multiple response function. The hydrogel material is responsive to temperature, light and redox, quick gelling can be achieved by adjusting temperature, bulk concentration, photo-polymerization initiator concentration and a light source, the hydrogel is easy to form and has excellent mechanical properties and biocompatibility, and redox responsiveness of the hydrogel helps load different drug molecules and release them effectively.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and particularly relates to a hydrogel with multiple response functions and a preparation method and application thereof. Background technique [0002] Hydrogel is a kind of hydrophilic polymer composed of polymer chain segments and has a three-dimensional cross-linked network structure. Hydrogels can absorb and retain a large amount of water but are insoluble in water, and maintain structural integrity in solutions and organisms. Because hydrogel has high water permeability and good biocompatibility, and has certain strength, the surface structure is similar to biological tissue, so it has received more and more attention and applications in the field of biomaterials, such as contact lenses , Drug sustained and controlled release, tissue scaffold construction, medical dressings, etc. [0003] According to the response of hydrogels to external stimuli, it is generally divided into traditional ordin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F290/06C08F230/00C08F2/48B33Y70/00A61K47/32A61K47/10C08L51/08
CPCA61K47/10A61K47/32B33Y70/00C08F2/48C08F290/06C08J3/075C08J2351/08C08F230/00
Inventor 薛巍张洁玲马栋王永周
Owner JINAN UNIVERSITY
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