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Composition for inhibiting growth of candida albicans and preparation method and application thereof

A technology of Candida albicans and composition, which is applied in the field of compositions for inhibiting the growth of Candida albicans, can solve the problems of widespread emergence of drug-resistant strains and increase the difficulty of treatment, achieve safety and no side effects, improve medication compliance, and produce low cost effect

Inactive Publication Date: 2017-08-18
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that Candida albicans is the most common fungal infection in cancer patients, while the emergence and spread of drug-resistant strains further complicates treatment
For example, triazole drugs such as fluconazole and itraconazole are commonly used in the clinical treatment of candidiasis, but the long-term use of these drugs has led to the widespread emergence of drug-resistant strains

Method used

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  • Composition for inhibiting growth of candida albicans and preparation method and application thereof
  • Composition for inhibiting growth of candida albicans and preparation method and application thereof
  • Composition for inhibiting growth of candida albicans and preparation method and application thereof

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preparation example Construction

[0027] Preferably, the components also include a third component, and the mass ratio of the third component to the first component is (3-5): 10; the preparation method of the third component comprises the following steps: combining perilla leaf, Artemisia argyi and Comfrey leaves are mixed evenly, and then soaked in rice wine with an alcohol content of 15% to 25% for 10 to 15 hours; the soaked mixture is heated at 60 to 70°C for 100 to 120 minutes, filtered, and the filtrate is collected; the filtrate is decolorized, It is then concentrated into an extract with a relative density of 1.2-1.3 measured at 80°C to obtain the third component; wherein the ratio of the total mass of perilla leaves, mugwort leaves and comfrey leaves to the mass of rice wine is (1-2):10 .

[0028] In addition, the present invention also provides a preparation method of the composition for inhibiting the growth of Candida albicans, comprising the following steps:

[0029] After uniformly mixing all the...

Embodiment 1

[0032] This embodiment provides a composition for inhibiting the growth of Candida albicans, comprising a first component and a second component, and the mass ratio of the first component to the second component is 10:1;

[0033] Wherein, the first component includes: a fermentation product obtained by fermentation of Streptomyces griseus and Streptomyces globisporus;

[0034] The fermentation method comprises the steps of:

[0035] S101: Inoculate the activated Streptomyces griseus into the fermentation medium, and the inoculum content is (5-10)×10 6 cfu / mL, fermented at 36°C for 8 hours, during the fermentation process: the ventilation rate is 0.1v / v min, the stirring speed is 120rpm; the pH value of the fermentation medium is 7.2, and the composition of the fermentation medium includes: glucose 2g / L , starch 5g / L, peptone 0.1g / L, yeast extract 0.4g / L, peanut cake powder 2g / L, soybean cake powder 10g / L, sodium chloride 0.2g / L, magnesium sulfate 0.5g / L, hydrogen phosphate D...

Embodiment 2

[0042] This embodiment provides a composition for inhibiting the growth of Candida albicans, comprising a first component and a second component, and the mass ratio of the first component to the second component is 10:2;

[0043] Wherein, the first component includes: a fermentation product obtained by fermentation of Streptomyces griseus and Streptomyces globisporus;

[0044] The fermentation method comprises the steps of:

[0045] S101: Inoculate the activated Streptomyces griseus into the fermentation medium, and the inoculum content is (5-10)×10 6 cfu / mL, fermented at 38°C for 10 hours, during the fermentation process: the ventilation rate is 0.2v / v min, the stirring speed is 150rpm; the pH value of the fermentation medium is 7.2, and the composition of the fermentation medium includes: glucose 2g / L , starch 5g / L, peptone 0.1g / L, yeast extract 0.4g / L, peanut cake powder 2g / L, soybean cake powder 10g / L, sodium chloride 0.2g / L, magnesium sulfate 0.5g / L, hydrogen phosphate ...

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Abstract

The invention relates to a composition for inhibiting growth of candida albicans and a preparation method and application thereof. The composition is prepared from a first component and a second component according to a mass ratio of 10:(1 to 2), wherein the first component comprises a fermenting product which is fermented by streptomyces griseus and streptomyces globisporus; the second component is prepared from the following components in parts by weight: 15 to 20 parts of vitamin B2, 8 to 12 parts of polyhexamethylene biguanide, 3 to 5 parts of citric acid, 0.5 to 1 part of glycyrrhizin, and 1 to 2 parts of sodium benzoate. The composition for inhibiting the growth of candida albicans has the advantages that by utilizing the streptomyces griseus and the streptomyces globisporus to ferment together, the obtained fermenting product is used as one of components; the prepared composition has the function of inhibiting the growth of candida albicans, and the inhibiting effect is obvious; the preparation method is simple, the production cost is low, and the quality is stable.

Description

technical field [0001] The invention relates to the technical field of antibacterial, in particular to a composition for inhibiting the growth of Candida albicans, a preparation method and application thereof. Background technique [0002] Candida albicans is a fungus that usually exists in the oral cavity, upper respiratory tract, intestinal tract, and vagina of normal people. It usually has a small number in normal organisms and does not cause diseases. When the immune function or general defense of the body is weakened or If the mutual restriction of normal flora is out of balance, the bacteria multiply in large numbers and change the growth form (sprout mycelium phase) to invade cells and cause diseases. Candida albicans is a common opportunistic pathogen, which usually causes local infection on the surface of human mucosa. In immunocompromised patients, Candida albicans often causes systemic infection. Due to the increasing number of HIV infection and tumor patients an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K36/535A61P31/10A61P31/04A61P15/02A61K31/525A61K31/785A61K31/194A61K31/704A61K31/192
Inventor 李长润
Owner ANHUI UNIVERSITY
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