Surface enhancement Raman scattering (SERS) substrate and preparation method of same

Abstract

The invention provides a surface enhancement Raman scattering (SERS) substrate and a preparation method of same. The SERS substrate employs cetyl trimethyl ammonium bromide (CTAB) as a morphology controlling agent and three-dimensional macroporous foamed nickel as a base material, is prepared through a replacement reaction of chloroauric acid and nickel, and has abundant high-enhancement-activity gold micro-nano conical spike-shaped structures which are uniformly distributed. The preparation method includes the steps of: under the effect of the CTAB, performing a reaction to the chloroauric acid and nickel at 20-30 DEG C for a certain period. The SERS substrate has a unique and uniformly distributed gold micro-nano cone-shaped array structure and a three-dimensional macroporous structure, has high enhancement performance of probe molecule Raman signals and has good repeatability in the enhanced signals. The SERS substrate can be used for high-sensitive surface enhanced Raman spectroscopy detection for dye molecules, such as crystal violet, malachite green, methylene blue and the like in environment. The preparation method is simple, is low in cost, is free of special instrument and has good repeatability.

Description

technical field [0001] The invention relates to the field of chemical analysis and detection, in particular to a surface-enhanced Raman scattering substrate and a preparation method thereof. Background technique [0002] Surface Enhanced Raman Scattering (SERS) is a highly sensitive analysis method, which refers to the Raman scattering of molecules when they are adsorbed on the surface of solids such as gold and silver, especially rough solids (ie substrates). The strength will be greatly enhanced (10 3 -10 6 times or even higher). To achieve this enhancement, a good enhancement substrate is essential. A good enhancement substrate needs to meet several conditions: high enhancement ability, good reproducibility of enhanced signal, and high substrate stability. In addition, low cost, easy preparation, and large-scale preparation are also crucial for the practical application of substrates. In terms of composition, the most effective materials for reinforcement are gold an...

AI Technical Summary

Problems solved by technology

The enhancement effect of the first enhanced substrate is relatively low, and the reproducibility of the enhanced signal is poor. This method is also not suitable for the preparation of enhanced substrates in large quantities.

The signal reproducibility of the preparation of the third substrate is very high, and the enhancement effect is also high, but the preparation process uses chemical vapor deposition technology, photolithography technology, electron (ion) beam etching technology, etc., which makes the whole substrate preparation The process is complex and expensive, which limits its practical application

Nevertheless, this type of substrate also has some disadvantages: (1) the spherical gold-silver nanoparticle-reinforced substrate is the easiest to prepare and the most widely used, but its enhancement effect on the Raman scattering signal of molecules is relatively low; (2) ) Enhanced substrates with spike-like structures (such as gold nano sea urchins, gold nano stars, etc.) have good enhancement effects, but the preparation process is complicated, the reaction conditions are high, and the reproducibility of the preparation method is low; (3) gold and silver nano The enhancement effect of particle aggregates is good, but the reproducibility of the enhancement signal is poor; (4) the enhancement effect of gold-silver nanoparticle assemblies is good and the cost is low, but the self-assembly process involves the precise control of weak forces and requires high Technical level, it is also difficult to prepare on a large scale

(5) Unlike the preparation of gold and silver nanoparticles in solution, there are relatively few reports on the preparation of gold and silver nanomaterials with different shapes and structures (especially with spike structures) directly on solid substrates. more difficult

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