Biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and method for preparing biocompatible polyurethane
A technology of sulfonated hydroxypropyl chitosan and sulfonated hydroxypropyl shell is applied in the field of sulfonated hydroxypropyl chitosan modified biocompatible polyurethane and its preparation, and can solve the problem of improving blood compatibility. Obviously, the modified materials are expensive, the grafting rate is not high, etc., to achieve the effects of good anticoagulant performance and biocompatibility, improved hydrophilicity and anti-protein pollution performance, and simple process flow
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Embodiment 1
[0038]Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;
[0039] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add octylic acid after a period of nitrogen. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyurethane prepolym...
Embodiment 2
[0041] Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;
[0042] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add sub-octanoic acid after nitrogen for a period of time. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyur...
Embodiment 3
[0044] Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;
[0045] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add sub-octanoic acid after nitrogen for a period of time. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyur...
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