Biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and method for preparing biocompatible polyurethane

A technology of sulfonated hydroxypropyl chitosan and sulfonated hydroxypropyl shell is applied in the field of sulfonated hydroxypropyl chitosan modified biocompatible polyurethane and its preparation, and can solve the problem of improving blood compatibility. Obviously, the modified materials are expensive, the grafting rate is not high, etc., to achieve the effects of good anticoagulant performance and biocompatibility, improved hydrophilicity and anti-protein pollution performance, and simple process flow

Inactive Publication Date: 2017-09-05
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods have problems such as cumbersome process, expensive grafted modified materials, low gra

Method used

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  • Biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and method for preparing biocompatible polyurethane
  • Biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and method for preparing biocompatible polyurethane
  • Biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and method for preparing biocompatible polyurethane

Examples

Experimental program
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Effect test

Embodiment 1

[0038]Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;

[0039] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add octylic acid after a period of nitrogen. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyurethane prepolym...

Embodiment 2

[0041] Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;

[0042] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add sub-octanoic acid after nitrogen for a period of time. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyur...

Embodiment 3

[0044] Using 5g CS as raw material, first alkalized with NaOH solution with a mass fraction of 33%, added to the reactor together with 50ml IPA and 50ml PO, stirred and reacted at 45 ℃ for 5h, poured into deionized water to dissolve and added acid After neutralization, acetone precipitation, suction filtration, washing and drying were carried out to obtain HPCS. 4ml of CSA and 20ml of formamide were made into a sulfonated reagent under an ice-salt bath, and then 2g of HPCS was added, and the reaction was stirred at 68°C for 3h, and the SHPCS was obtained by dialysis, deamination, re-dialysis, and concentration and drying;

[0045] Using N,N-dimethylacetamide (DMAc) as a solvent, add diphenylmethane diisocyanate (MDI) and polyethylene glycol (PEG) with a molar ratio of 1.15:1 in turn, and add sub-octanoic acid after nitrogen for a period of time. Tin was mixed and stirred under anhydrous, oxygen-free, nitrogen protection, and reacted at 75 °C for 2 h to obtain a modified polyur...

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Abstract

The invention discloses biocompatible polyurethane modified by sulfonated hydroxypropyl chitosan and a method for preparing the biocompatible polyurethane. The method includes synthesizing the sulfonated hydroxypropyl chitosan from chitosan by means of etherification reaction and sulfonation treatment, then adding diphenyl-methane-diisocyanate, polyethylene glycol and catalysts into a reactor and carrying out stirring reaction under the protection of nitrogen at the temperatures of 70-80 DEG C for 2-4 h; adding the sulfonated hydroxypropyl chitosan into reaction products and carrying out cooling reaction for 6-12 h to obtain the biocompatible polyurethane modified by the sulfonated hydroxypropyl chitosan. The biocompatible polyurethane and the method have the outstanding advantages that the sulfonated hydroxypropyl chitosan which is a water-soluble heparinoid substance is covalently grafted on polyurethane long chains, and accordingly the hydrophilicity and the anticoagulation properties of polyurethane can be greatly improved; processes are simple, reaction conditions are mild and are easy to control, and raw materials are easily available and are low in cost.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a sulfonated hydroxypropyl chitosan modified biocompatible polyurethane and a preparation method thereof. Background technique [0002] Polyurethane has excellent physical and mechanical properties, good biocompatibility, low toxicity, and is mostly used in the manufacture of artificial hearts, artificial blood vessels, artificial skin and various catheters and medical materials in interventional surgery. However, the hydrophobicity of traditional polyurethane limits its use in some aspects. For example, when polyurethane is in direct contact with blood, the surface is easily contaminated by blood proteins, and prolonged contact can easily lead to the formation of thrombus, and long-term implantation into the body It is easy to cause an inflammatory response in the body. The invention aims to solve a series of problems such as thrombus occurring during the use of the polyuret...

Claims

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Application Information

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IPC IPC(8): C08G18/40C08G18/48C08G18/64C08G18/10
CPCC08G18/10C08G18/4081C08G18/4833C08G18/6484C08G18/64
Inventor 邱运仁许静杰涂明明
Owner CENT SOUTH UNIV
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