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Multifunctional nanofiber wound repair biological dressing and preparation method thereof

A wound repair and nanofiber technology, applied in fiber processing, fiber chemical characteristics, cellulose/protein conjugated man-made filaments, etc., can solve the problems of limited industrial application, functional obstacles, complex controllability of spinning equipment, etc. Achieve the effect of promoting migration and reproduction, high porosity, and good degradability

Active Publication Date: 2017-10-10
JILIN UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the multilayer composite method, the functional substances in the layer in direct contact with the wound can effectively interact with the wound, but the functional substances in the layer that cannot directly contact the wound are hindered from interacting with the wound.
In the coaxial spinning method, the complexity of the spinning equipment and the difficulty in controllability also limit its industrial application

Method used

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  • Multifunctional nanofiber wound repair biological dressing and preparation method thereof
  • Multifunctional nanofiber wound repair biological dressing and preparation method thereof
  • Multifunctional nanofiber wound repair biological dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Three kinds of spinning solution A, spinning solution B and spinning solution C loaded with different functional substances are configured, wherein:

[0031] Spinning solution A configuration: dissolve polylactic acid in the solvent chloroform, wherein the high molecular mass concentration is 5wt%, and then add 0.5wt% antibiotic drug mupirocin relative to the high molecular weight, and stir until the solution is transparent and uniform. Obtain spinning solution A;

[0032]Spinning solution B configuration: dissolve the water-soluble synthetic polymer polyvinyl alcohol in water, wherein the high molecular weight concentration is 6wt%, and then add 2wt% crosslinking agent glutaraldehyde relative to the high molecular weight, and then add the relative Add 1 wt% of the high molecular weight enzyme substance bromelain, and stir until the solution is transparent and uniform to obtain the spinning solution B;

[0033] Spinning solution C configuration: dissolve polyuretha...

Embodiment 2

[0039] (1) Three kinds of spinning solution A, spinning solution B and spinning solution C loaded with different functional substances are configured, wherein:

[0040] Spinning solution A configuration: dissolve polycaprolactone in a mixed solution of solvent chloroform and N,N-dimethylformamide, wherein the high molecular weight concentration is 12wt%, and then add 5wt% of the high molecular weight Antibiotic drug erythromycin, stirred until the solution is transparent and uniform to obtain spinning solution A;

[0041] Spinning solution B configuration: dissolve water-soluble synthetic polymer polyvinyl alcohol and carboxymethyl chitosan in water, wherein the high molecular weight concentration is 20wt%, and then add 0.1wt% crosslinking agent Jing relative to the high molecular weight Nipin, and then add 20wt% enzyme substance papain relative to the high molecular weight, and stir until the solution is transparent and uniform to obtain the spinning solution B;

[0042] Spi...

Embodiment 3

[0046] (1) Three kinds of spinning solution A, spinning solution B and spinning solution C loaded with different functional substances are configured, wherein:

[0047] Spinning solution A configuration: the polylactic acid-glycolic acid copolymer is in the mixed solution of solvent chloroform and acetone, wherein high molecular weight concentration is 35wt%, after adding the antibiotic drug levofloxacin of 3wt% relative to high molecular weight, stir The spinning solution A is obtained until the solution is transparent and uniform;

[0048] Spinning solution B configuration: dissolve water-soluble synthetic polymer polyvinyl alcohol and sodium alginate in water, wherein the high molecular weight concentration is 12wt%, and then add 1wt% crosslinking agent genipin relative to the high molecular weight, and then Then add 3 wt% enzyme substance lysozyme relative to the high molecular weight, and stir until the solution is transparent and uniform to obtain the spinning solution B...

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Abstract

The invention relates to a multifunctional nanofiber wound repair biological dressing and a preparation method thereof, and belongs to the technical field of nanofiber materials. The dressing is prepared by a three-needle electrostatic spinning device, macromolecular spinning solution loading different functional substances are placed in a needle A, a needle B and a needle C, and the three needles simultaneously perform spinning to obtain the multifunctional composite nanofiber dressing. The dressing can meet the increasing demand of people for wound repair biological dressings, can effectively achieve various functions of inhibiting scars, eliminating edema, resisting bacteria, preventing infection and the like, and can effectively accelerate wound healing. Besides, the preparation process is simple and easy, and industrial production is easily realized.

Description

technical field [0001] The invention belongs to the technical field of nanofiber materials, and in particular relates to a nanofiber wound repair biological dressing and a preparation method thereof. Background technique [0002] Every year, millions of people in our country suffer from skin injuries due to accidents and surgeries. Post-injury scars are an important factor affecting the prognosis and quality of life of patients. Traditional materials can no longer meet the needs of fine-tuned wound healing. Therefore, skin repair materials are biomimetic and functional. It has become a research hotspot of scholars at home and abroad. The special 3D structure of nanofibers prepared by electrospinning is very similar to the extracellular matrix structure of the human body, which is conducive to cell adhesion and reproduction. Nanofibers prepared by this method have good application value in the field of biomedicine. In recent years, the research on the application of electros...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/24A61L15/26D01F8/14D01F8/16D01F8/10D01F8/18D01F8/02D01F1/10D01D5/00
CPCA61L15/24A61L15/26A61L15/28A61L15/32A61L15/425A61L2300/254A61L2300/406A61L2300/43A61L2300/604A61L2400/12D01D5/0061D01D5/0069D01D5/0092D01F1/10D01F8/02D01F8/10D01F8/14D01F8/16D01F8/18C08L67/04C08L89/00C08L5/08C08L5/04C08L75/04C08L29/04
Inventor 陈欣欣于家傲王祥王策赵锐金正花高欣欣
Owner JILIN UNIV FIRST HOSPITAL
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