Method for extracting scopolamine by virtue of membrane separation technique

A scopolamine and membrane separation technology, applied in the direction of organic chemistry, can solve the problems of difficult to meet high-purity product purity, tedious and time-consuming extraction process, low scopolamine content, etc., to achieve shortened production time, low production cost, and high product yield. rate effect

Inactive Publication Date: 2017-10-10
ANHUI DEXINJIA BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction of scopolamine mainly uses Dajinhua as raw material, and generally uses organic solvents such as chloroform to extract or directly perform column chromatography separation after crude extraction. The organic solvent extraction process is cumbersome and time-consuming with serious organic pollution, and the purity of the final product is also difficult. To meet the high-purity requirements, and repeated extractions are likely to cause loss of raw materials, and the yield is low. However, the method of directly perfor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1:

[0036] In this embodiment, the method for extracting scopolamine using membrane separation technology is as follows:

[0037] 1. Pretreatment

[0038] Place the raw datum flower in a vacuum drying oven at 40°C for 24 hours, take it out and pulverize it with a pulverizer and pass through a 100-mesh sieve to obtain datum flower powder;

[0039] 2. Separation and extraction

[0040] Add HCl solution with a mass concentration of 0.1% to the lichen flower powder in a mass-volume ratio of 1g:9mL. After mixing, sonicate for 30 minutes with an ultrasonic power of 250W and a frequency of 40Hz. The ultrasonically processed materials are suction filtered to obtain filter residue and For the filtrate, add HCl solution to the obtained filter residue again to repeat the above-mentioned ultrasonic treatment process, and combine the filtrate obtained twice after suction filtration to obtain the scopolamine extract;

[0041] 3. Ultrafiltration to remove impurities

[0042] The scopola...

Example Embodiment

[0055] Example 2:

[0056] The preparation process of this embodiment is the same as that of embodiment 1, except that the membrane molecular weight cut-off of the ultrafiltration and impurity removal process in step 3 is 6K.

[0057] Take a certain amount of scopolamine extract and place it in a rotary evaporator to recover the solids to obtain a dry extract, weigh it, then take the same amount of ultrafiltration to remove impurities, and place the effluent in the rotary evaporator to recover the solids to obtain a dry extract. The weight is calculated according to the formula Calculate the impurity removal rate, the impurity removal rate = (equivalent dry solids of scopolamine extract-equivalent dry solids of scopolamine ultrafiltration dialysate) / equal dry solids of scopolamine extract × 100%, to obtain the impurity removal of this embodiment The rate is 96.17%.

[0058] Take the scopolamine extract and inject it into a high performance liquid chromatograph for detection and an...

Example Embodiment

[0059] Example 3:

[0060] The preparation process of this embodiment is the same as that of embodiment 1, except that the membrane molecular weight cut-off of the ultrafiltration and impurity removal process in step 3 is 50K.

[0061] Take a certain amount of scopolamine extract and place it in a rotary evaporator to recover the solids to obtain a dry extract, weigh it, then take the same amount of ultrafiltration to remove impurities, and place the effluent in the rotary evaporator to recover the solids to obtain a dry extract. The weight is calculated according to the formula Calculate the impurity removal rate, the impurity removal rate = (equivalent dry solids of scopolamine extract-equivalent dry solids of scopolamine ultrafiltration dialysate) / equal dry solids of scopolamine extract × 100%, to obtain the impurity removal of this embodiment The rate is 80.74%.

[0062] Take the scopolamine extract and inject it into a high performance liquid chromatograph for detection and a...

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Abstract

The invention discloses a method for extracting scopolamine by virtue of a membrane separation technique. A scopolamine finished product is prepared by the following steps: raw material pretreatment, preparation of a scopolamine extracting solution, ultrafiltration impurity removal, sodium filter desalination, reduced pressure concentration and drying, resin bed purification, scopolamine salt formation and the like. The scopolamine extracting solution is preliminarily purified and concentrated through operations of impurity removal, desalination and the like by virtue of the membrane separation technique and is highly purified through column chromatography, so that the production time is greatly shortened, and the production efficiency is improved; and compared with a conventional method, the product yield and the product purity are relatively high, and the method is applicable to industrial production.

Description

technical field [0001] The invention relates to a method for extracting scopolamine by adopting membrane separation technology, which belongs to the field of separation and purification of medicines. Background technique [0002] Scopolamine is an alkaloid with the strongest pharmacological action in belladonna. It is a viscous syrupy liquid at room temperature with a bitter and pungent taste; it is easily soluble in ethanol, chloroform, acetone and hot water, and slightly soluble in benzene and petroleum ether. It can form crystalline salts with a variety of inorganic or organic acids. The effect of scopolamine is similar to that of atropine. Its mydriasis and inhibition of glandular secretion are stronger than atropine. It has an exciting effect on the respiratory center, but it has a significant inhibitory effect on the cerebral cortex. It also has the effects of dilating capillaries, improving microcirculation, and anti-seasickness. It is clinically used as a sedative, ...

Claims

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Application Information

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IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 许坤张文成付传香惠爱玲
Owner ANHUI DEXINJIA BIOPHARM
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