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A starch-based microporous hemostatic material with antibacterial properties and its preparation method and application

A hemostatic material, starch-based technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., to achieve good degradation performance, good biocompatibility, and good antibacterial performance

Active Publication Date: 2021-09-24
苏州佰济生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports of materials that combine the above properties

Method used

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  • A starch-based microporous hemostatic material with antibacterial properties and its preparation method and application
  • A starch-based microporous hemostatic material with antibacterial properties and its preparation method and application
  • A starch-based microporous hemostatic material with antibacterial properties and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0065] Preparation method of starch-based microporous hemostatic material

[0066] The preparation method of the starch-based microporous hemostatic material of the present invention comprises the following steps:

[0067] (1) Preparation of microporous starch

[0068] Add starch and enzyme to phosphate buffer, stir at 40-80°C and pH 4-8, carry out enzymolysis reaction, after 3-16 hours, separate by suction filtration, dry to obtain microporous starch; ,

[0069] The mass ratio of the starch and the enzyme is 1: (0.01-0.3);

[0070] The mass volume ratio of the total amount of the starch and enzyme to the phosphate buffer is 100g: (150-1000) mL;

[0071] (2) Cationization of microporous starch

[0072] Mix and stir the microporous starch, cationic modifier, catalyst and water prepared in step (1) according to a certain ratio, keep stirring and insulate for reaction at 30-80°C for 4-30 hours, and mix with water-isopropanol After the mixed solution is centrifuged and washed...

Embodiment 1

[0110] (a) Preparation of microporous starch

[0111] Add 100g of cornstarch and 3g of glucoamylase into 300mL of phosphate disodium hydrogen phosphate aqueous buffer solution with pH=6, stir evenly, carry out enzymolysis reaction at 45°C for 8h, vacuum filter and wash, and freeze-dry Dry in the machine for 20 hours to obtain corn microporous starch.

[0112] (b) Cationization of microporous starch

[0113] Dissolve 10g of corn microporous starch in 45g of water, add 0.25g of potassium hydroxide and 3.0g of methylene dimethylamine hydrochloride, stir well, react at 50°C for 20h, and carry out the reaction with a mixture of water and isopropanol Wash by centrifugation and dry in a freeze dryer for 20 hours to obtain aminated corn microporous starch. Sample form such as figure 1 shown.

Embodiment 2～5

[0115] Examples 2-5 Repeat the experimental steps of Example 1, the difference lies in some experimental conditions, as shown in Table 1-2.

[0116] Table 1 Preparation of microporous starch

[0117]

[0118] Table 2 Cationization of microporous starch

[0119]

[0120] Adopt scanning electron microscope to observe respectively the microporous starch (see figure 2 (a) and 2 (b)) and the microporous starch (see figure 2 (c) and 2(d)). It can be seen from the figure that the microporous starch without amino groups has a particle diameter of about 10-20 μm and a pore diameter of about 1-4 μm, and the micropores remain intact after amino group modification.

[0121] The amino group-loaded microporous starch prepared in Example 2-5 has a particle diameter of about 9-30 μm and a pore diameter of about 0.5-5 μm.

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Abstract

The invention discloses a starch-based microporous hemostatic material with antibacterial properties, a preparation method and application thereof. The present invention first prepares starch-based microporous starch, and then loads amino ions, thereby finally preparing a pore size of 0.1-6 μm, a hemostasis time of 20s-4min, a bactericidal rate of 50%-100%, and 4h-10d that can be completely degraded in vivo Positively charged starch-based microporous hemostatic material. The material can quickly and effectively stop bleeding and also has antibacterial function, which can prevent infection of the wound site and accelerate wound healing, but has no damage to normal cells. The present invention adopts starch with wide sources and low price as raw material, and loads amino groups after microporation, thus preparing a hemostatic material with physical and chemical hemostatic mechanism, which has fast hemostatic speed, high viscosity and good biocompatibility. It degrades quickly in the body, has a wide range of applications, and has dual functions of hemostasis and antibacterial.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing tissue damage, and in particular relates to a starch-based microporous hemostatic material with antibacterial properties and a preparation method and application thereof. Background technique [0002] Bleeding is a phenomenon in which blood flows from blood vessels or the heart to interstitial spaces, body cavities or outside the body. It is more common in wars, traffic accidents, natural disasters, first aid and surgical operations. Bleeding is often accompanied by infection, which may even endanger human life. Therefore, it is imperative to prepare a new type of rapid hemostasis material with superior performance. [0003] After the hemostasis is completed, the surface of the wound is covered with residual materials and is exposed to the air for a long time. At this time, bacteria in the air will reside on the surface of the material, so that the residual material of the wound beco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/64
CPCA61L15/28A61L15/425A61L15/64A61L2400/04C08L3/04
Inventor 刘昌胜陈芳萍曹晓艳
Owner 苏州佰济生物科技有限公司
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