Nanometer composite antibacterial agent with cerium loaded on porous graphene and method for preparing nanometer composite antibacterial agent

A porous graphene and nanocomposite technology, applied in graphene, nanocarbon, pharmaceutical formulations and other directions, can solve the problems of susceptibility to infection, insufficient mechanical strength, uneven pore size distribution, etc. The effect of good specific surface area

Inactive Publication Date: 2017-12-01
长沙小新新能源科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a medical material, its use process has the characteristics of susceptibility to infection and long cycle, so higher requirements are put forward for the antibacterial performance of the material
Single-component porous materials often have random pores, uneven pore size distribution, insufficient mechanical strength, poor degradation performance, and poor biocompatibility. Their structural characteristics determine their performance defects and severely limit the use of such materials application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of porous graphene loaded cerium nanocomposite antibacterial agent, comprising the following steps:

[0025] S1. Calculated in parts by weight, under the conditions of ice-water bath and stirring, 10 parts of phosphorus pentoxide and 10 parts of potassium persulfate are slowly added into the container that 25 parts of mass fraction are 98% sulfuric acid, and then the container is heated to After 82°C, slowly add 20 parts of natural flake graphite, react under stirring conditions for 12 hours, cool and dilute with water after the reaction, and then filter and dry to obtain pre-oxidized graphite;

[0026] S2. In parts by weight, slowly add 28 parts of potassium permanganate, 13 parts of calcium chloride intercalation agent and 10 parts of pre-oxidized graphite into 300 parts of sulfuric acid with a mass fraction of 98%, and react at 35°C for 3h, After the reaction, slowly add 5 parts of hydrogen peroxide with a mass fraction of 20%, then dilute with d...

Embodiment 2

[0030] A preparation method of porous graphene loaded cerium nanocomposite antibacterial agent, comprising the following steps:

[0031] S1. Calculated in parts by weight, under the conditions of ice-water bath and stirring, 10 parts of phosphorus pentoxide and 10 parts of potassium persulfate are slowly added to the container that 30 parts of mass fraction is 98% sulfuric acid, and then the container is heated to After 86°C, slowly add 20 parts of natural flake graphite, react under stirring conditions for 12 hours, cool and dilute with water after the reaction, and then filter and dry to obtain pre-oxidized graphite;

[0032] S2. In parts by weight, slowly add 25 parts of potassium permanganate, 15 parts of calcium chloride intercalation agent and 10 parts of pre-oxidized graphite into 300 parts of sulfuric acid with a mass fraction of 98%, react at 35°C for 3h, After the reaction, slowly add 5 parts of hydrogen peroxide with a mass fraction of 27%, then dilute with deionize...

Embodiment 3

[0036] A preparation method of porous graphene loaded cerium nanocomposite antibacterial agent, comprising the following steps:

[0037] S1. Calculated in parts by weight, under the conditions of ice-water bath and stirring, 10 parts of phosphorus pentoxide and 10 parts of potassium persulfate are slowly added into the container that 27 parts of mass fractions are 98% sulfuric acid, and then the container is heated to After 85°C, slowly add 20 parts of natural flake graphite, react under stirring conditions for 12 hours, cool and dilute with water after the reaction, and then filter and dry to obtain pre-oxidized graphite;

[0038] S2. In parts by weight, slowly add 30 parts of potassium permanganate, 10 parts of calcium chloride intercalation agent and 10 parts of pre-oxidized graphite into 300 parts of sulfuric acid with a mass fraction of 98%, and react at 35°C for 3h, After the reaction, slowly add 5 parts of hydrogen peroxide with a mass fraction of 30%, then dilute with ...

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Abstract

The invention discloses a nanometer composite antibacterial agent with cerium loaded on porous graphene and a method for preparing the nanometer composite antibacterial agent. The nanometer composite antibacterial agent with the cerium loaded on the porous graphene comprises the three-dimensional porous graphene, the nanometer cerium and nanometer titanium dioxide. The nanometer cerium and the nanometer titanium dioxide are deposited on three-dimensional porous graphene sheet layers, and the specific surface area of the nanometer composite antibacterial agent with the cerium loaded on the porous graphene is 1200-1470 m<2> / g. The nanometer composite antibacterial agent and the method have the advantages that graphene oxide is etched by potassium hydroxide, then composition is carried out on the graphene oxide and cerium nitrate, three-dimensional graphene composite nanometer cerium materials are prepared by means of reduction by the aid of hydrothermal processes, tert-butyl alcohol and the nanometer titanium dioxide are mixed with each other to replace water in the three-dimensional porous graphene, then freeze-drying is carried out, and the nanometer composite antibacterial agent with the cerium loaded on the porous graphene is ultimately obtained by means of calcining; the nanometer composite antibacterial agent prepared by the aid of the method has the large specific surface area, and good loading effects can be realized by the nanometer composite antibacterial agent.

Description

technical field [0001] The invention belongs to the field of composite antibacterial materials, in particular to a porous graphene-supported cerium nanocomposite antibacterial agent and a preparation method thereof. Background technique [0002] The porous material has an open and connected pore structure and a super high specific surface area, and its structural characteristics determine its excellent adsorption capacity. At the same time, as a medical material, porous materials can promote tissue regeneration and reconstruction because of their open interconnected pore structure, which is conducive to the transmission of water and nutrients and the discharge of metabolites, and the unique porous structure can improve its own biocompatibility. As a drug carrier, porous materials not only have the advantages of high drug loading, uniform dispersion, and short material degradation cycle, but also have the effect of sustained drug release, which can prolong the drug effect, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/184A61L27/56A61L27/08A61L27/04A61L27/02A61L27/40A61L27/54
CPCA61L27/08A61L27/025A61L27/047A61L27/40A61L27/54A61L27/56A61L2300/102A61L2300/404A61L2300/624A61L2400/12C01P2004/30C01P2006/12
Inventor 不公告发明人
Owner 长沙小新新能源科技有限公司
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