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Application of dipeptide diaminobutyroyl benzylamide diacetate in preparation of skin ulcer treatment medicine

A skin ulcer and tripeptide technology, which is applied in the field of biomedicine, can solve the problems that have not been reported in the literature about the application of snake venom tripeptide, and achieve good skin ulcer effect

Active Publication Date: 2017-12-15
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although snake venom tripeptides are widely used, there is no literature report on the application of snake venom tripeptides in the treatment of diabetic wounds

Method used

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  • Application of dipeptide diaminobutyroyl benzylamide diacetate in preparation of skin ulcer treatment medicine
  • Application of dipeptide diaminobutyroyl benzylamide diacetate in preparation of skin ulcer treatment medicine
  • Application of dipeptide diaminobutyroyl benzylamide diacetate in preparation of skin ulcer treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Effect of snake venom tripeptide on diabetic skin wounds

[0032] 1) Grouping: 30 SPF-grade male SD rats with a body weight of 200±20 g were purchased from the Experimental Animal Center of Guangdong Province. After adaptive feeding for 1 week, the SD rats were randomly divided into 6 groups with 5 rats in each group: ①Normal control group , ② diabetes group, ③ diabetes + snake venom tripeptide group, ④ snake venom tripeptide group, ⑤ diabetes + epidermal growth factor group; ⑥ epidermal growth factor group.

[0033] 2) Type 2 diabetes model preparation: a one-time intraperitoneal injection of streptozotocin (STZ, 35mg / kg) was used to induce the type 2 diabetes rat model, and the other groups were injected with an equal volume of 0.1mol / L citrate buffer, Urinary sugar was measured using clinical routine random urine sugar paper for three consecutive days. If the urine sugar was ++~++++ or the fasting blood sugar ≥ 11.0mmol / l was measured twice every other day, t...

Embodiment 2

[0041] Example 2 Effect of snake venom tripeptide on the expression of inflammatory mediators in the skin of diabetic rats

[0042] The results of ELISA assay showed that: compared with the normal rat group, the contents of pro-inflammatory factors TNF-a and IL-6 around the wound of diabetic rats were significantly increased, and the contents of anti-inflammatory factor IL-4 were significantly reduced; compared with the diabetic rat group, The snake venom tripeptide group significantly inhibited the increase of the content of inflammatory factors TNF-a, IL-6 and anti-inflammatory factor IL-4 in diabetic rats, and the inhibitory effect was better than that of epidermal growth factor; the ELISA measurement data are shown in Table 1.

[0043] Table 1

[0044]

[0045] Note: the data in Table 1 are represented by mean ± standard error, n=5; * means p<0.05, ** means p<0.01 (compared with Control); # means p<0.05, ## means p<0.01 (compared with Control) DM comparison); Control i...

Embodiment 3

[0046] Example 3 Effect of snake venom tripeptide on the expression of nitric oxide synthase in the skin of diabetic rats

[0047] This study found that the activity of total NOS (nitric oxide synthase) in the skin tissue around the wound of diabetic rats was significantly reduced; further testing found that the activity of cNOS (constructive nitric oxide synthase) in the skin around the wound of diabetic rats was reduced , the activity of iNOS (inducible nitric oxide synthase) was increased; snake venom tripeptide treatment can completely cancel the inhibition of diabetes on the total NOS activity, and the cNOS activity can be restored to normal, but the iNOS activity is also significantly inhibited; these effects are better than those of the epidermis Growth factors were more effective; the results of the assay are shown in Table 2.

[0048] Table 2

[0049]

[0050] Note: The data in Table 1 are expressed as mean ± standard error, n=6.

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Abstract

The invention discloses an application of dipeptide diaminobutyroyl benzylamide diacetate in the preparation of a skin ulcer treatment medicine. The skin ulcer prevention or treatment medicine includes dipeptide diaminobutyroyl benzylamide diacetate and pharmaceutically acceptable auxiliary materials, and every 1000 g of the medicine contains 0.1-5.0 mg of the dipeptide diaminobutyroyl benzylamide diacetate; and the dosage of the medicine is a solution, an ointment, a gel, a microsphere or a spray. The medicine has a good skin ulcer treatment effect, and the adding sequence and the addition amount of the medicine component in the medicine are strictly controlled to make the dipeptide diaminobutyroyl benzylamide diacetate be well dissolved in a solvent and perform synergistic effects together with the auxiliary materials.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of snake venom tripeptide in the preparation of medicine for skin ulcer. Background technique [0002] At present, there are some clinical treatment methods to deal with unhealed wounds, including drug treatment, surgical treatment and autologous stem cell transplantation, etc.; however, the curative effect of drug treatment is very limited and the cycle is long, and the cost of surgery and autologous stem cell transplantation is high. And it requires high patient tolerance. Therefore, companies are paying more and more attention to the research and development of new drugs that promote wound granulation growth and wound healing, in order to shorten the course of the disease and reduce the disability rate. [0003] Among the various complications of diabetes, diabetic foot is a common and serious complication, and it is also the most refractory di...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61K9/08A61K9/06A61K47/10A61K47/12A61K47/34A61K47/02A61P17/02A61P3/10A61P29/00A61K31/047A61K31/198
CPCA61K9/06A61K9/08A61K31/047A61K31/198A61K38/06A61K47/02A61K47/10A61K47/12A61K47/34A61K2300/00
Inventor 熊燕付四海李晓媚
Owner GUANGZHOU MEDICAL UNIV
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