Tyramine/diphosphonate hyaluronic acid macromolecular compound and hydrogel, and preparation method and application thereof

A polymer compound and bisphosphonate technology, applied in the field of bone repair materials, can solve the problems of weak tissue penetration and difficult bone repair materials to trace in vivo, and achieve the promotion of bone repair ability, good in vivo degradation characteristics, and good bone repair. The effect of repair ability
CN107488240AInactive Publication Date: 2017-12-19INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF
Publication Date
2017-12-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of a bone repairing material, and provides a tyramine / diphosphonate hyaluronic acid macromolecular compound and a radionuclide marked tyramine / diphosphonate hyaluronic acid macromolecular compound, a preparation method of the tyramine / diphosphonate hyaluronic acid macromolecular compound and the radionuclide marked tyramine / diphosphonate hyaluronic acid macromolecular compound, hydrogel formed on the basis of the tyramine / diphosphonate hyaluronic acid macromolecular compound and the radionuclide marked tyramine / diphosphonate hyaluronic acid macromolecular compound, and the application of the hydrogel in the fields of biological material in vivo tracing and bone repairing. The two kinds of hydrogel provided by the invention serving as bone tissue repairing materials have good bone repair promoting capability in a living body; the radionuclide marked hydrogel is an in-vivo tracing bone tissue repairing material, not only can trace and know the material filling effect in vivo, but also can deeply know the degradation process through nuclear medicine imaging. In particular, the hydrogel marked by therapeutic radionuclides 188Re and 177Lu has a certain treatment effect on bone tissue necrosis inflammation or cancerization, and has double functions of imaging in vivo and repairing the bone tissues.
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Description

technical field

[0001] The invention belongs to the field of bone repair materials, and relates to a tyramine / bisphosphonate-hyaluronic acid macromolecular compound and a radionuclide-labeled tyramide / bisphosphonate-hyaluronic acid macromolecular compound, and a preparation method for the two. The hydrogels formed on the basis of them and the applications of the hydrogels. Background technique

[0002] Most of the clinical treatment methods for large bone tissue necrosis, loss and fracture are traditional autologous bone transplantation, but this method is limited by the fact that the donor cannot meet the needs of large damaged bone repair. In medicine, bone substitute materials are mainly used to fix it. At present, the metal-inorganic bone substitute materials commonly used in medicine are not organic components of the human body, and the materials need to be manually fixed on the parts that need to be repaired. Some materials have a limited service life and require mult...

Claims

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