Preparation method of biological activity calcium metaphosphate whisker degradable artificial bone

A calcium metaphosphate, bioactive technology, applied in the field of biomaterial active artificial bone preparation, to achieve the effects of high activity, high mechanical and mechanical properties, and high degradability

Inactive Publication Date: 2018-01-05
北京交泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main purpose of the present invention is to overcome the defects existing in the existing calcium phosphate preparation method, and provide a kind of preparation method of new calcium phosphate ceramics, the technical problem to be solved is to utilize the toughening of calcium metaphosphate whisker efficiently, Biological activity effectively improves the calcium phosphate activity and mechanical properties of calcium phosphate, and comprehensively utilizes the degradability of calcium phosphate, and the process is simple

Method used

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  • Preparation method of biological activity calcium metaphosphate whisker degradable artificial bone

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preparation example Construction

[0027] 2) Patent for preparation of calcium phosphate nanopowder (CN104108693A)

[0028] 3) Preparation of sintering aids

[0029] Magnesium oxide, sodium carbonate, diammonium hydrogen phosphate, and calcium oxide are used as raw materials, mixed evenly in water, and dried at 90 degrees. Put it in a crucible at 930-950 degrees for half an hour. Cool naturally with the furnace, add deionized water to the ball mill tank, grind and filter, dry at 100 degrees, and the weight composition is 62P2O5-14CaO-13MgO-11Na2O.

[0030] 4) Preparation of highly active degradable calcium phosphate porous artificial bone

[0031] Add dispersant, the above sintering aids, and tricalcium phosphate powder as raw materials to prepare slurry. Impregnated in a foam sponge. Sintered at 960-970 degrees for 2 hours, obtained by natural cooling. Wherein the weight ratio of calcium metaphosphate whiskers to tricalcium phosphate is 1:4.

Embodiment 1

[0033] 1) Preparation of bioactive calcium metaphosphate whiskers

[0034] Use phosphoric acid, calcium nitrate, and alcohol solution as raw materials to configure the solution, adjust the molar ratio of calcium and phosphorus to 0.5, use CO2 gas cylinders and ammonia water to slowly pass ammonia gas into the above solution for neutralization, and precipitate calcium dihydrogen phosphate whiskers. The above whiskers are calcined at a low temperature of 200 degrees to obtain calcium metaphosphate whiskers.

[0035] 2) Patent for preparation of calcium phosphate nanopowder (CN104108693A)

[0036] 3) Preparation of sintering aids

[0037] Magnesium oxide, sodium carbonate, diammonium hydrogen phosphate, and calcium oxide are used as raw materials, mixed evenly in water, and dried at 90 degrees. Put it in a crucible at 935 degrees for half an hour. Cool naturally with the furnace, add deionized water to the ball mill tank, grind and filter, dry at 100 degrees, and the weight co...

Embodiment 2

[0041] 1) Preparation of bioactive calcium metaphosphate whiskers

[0042] Use phosphoric acid, calcium nitrate, and alcohol solution as raw materials to configure the solution, adjust the molar ratio of calcium and phosphorus to 0.5, use CO2 gas cylinders and ammonia water to slowly pass ammonia gas into the above solution for neutralization, and precipitate calcium dihydrogen phosphate whiskers. The above whiskers are calcined at a low temperature of 200 degrees to obtain calcium metaphosphate whiskers.

[0043] 2) Patent for preparation of calcium phosphate nanopowder (CN104108693A)

[0044] 3) Preparation of sintering aids

[0045] Magnesium oxide, sodium carbonate, diammonium hydrogen phosphate, and calcium oxide are used as raw materials, mixed evenly in water, and dried at 90 degrees. Put it in a crucible at 945 degrees for half an hour. Cool naturally with the furnace, add deionized water to the ball mill tank, grind and filter, dry at 100 degrees, and the weight co...

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Abstract

The present invention relates to a method for degrading artificial bone by biologically active calcium metaphosphate whiskers. Using the bioactive properties of calcium metaphosphate whiskers to improve the bioactivity of tricalcium phosphate materials, it has both activity and degradability without introducing impurities, and has high biocompatibility. At the same time, the whiskers have a toughening effect and have high mechanical and mechanical properties. . However, the melting temperature of calcium metaphosphate whisker is very low, it will melt at 970 degrees, and it is difficult to exist stably at a high temperature of 1100 degrees sintering temperature, which affects the mechanical toughness. In order to solve this problem, calcium and phosphorus additives that can be sintered at low temperature are used to sinter at 960 degrees, so that the material has good toughness and activity.

Description

technical field [0001] The invention relates to a preparation process of biomaterial active artificial bone, in particular to a preparation process of calcium metaphosphate whisker calcium phosphate artificial bone composite material. Background technique [0002] Tricalcium phosphate is an important biological material, its chemical composition is similar to that of human bone, it can be degraded in vivo, and the degraded components are excreted from the body. However, tricalcium phosphate lacks biological activity. Osteogenesis cannot be induced in vivo, and the activity is very poor. And brittle, poor strength. Make the application value is not very high. [0003] In view of the defects in the above-mentioned existing calcium phosphate preparation method, the present inventor actively researches and innovates based on rich practical experience and professional knowledge in the design and manufacture of this type of product for many years, and cooperates with the applic...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/63C04B35/81C04B38/06A61L27/12A61L27/56A61L27/58
Inventor 于显著王静李锋涛
Owner 北京交泰科技有限公司
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