Madecassoside liposomal gel for local external application and preparation method thereof

The technology of madecassoside and liposome gel is applied in the field of pharmaceutical preparations and skin care products, which can solve the problems of increased skin dosage, strong fluidity, waste of drugs, etc., so as to be beneficial to wound healing without irritation. Effect, good fit effect

Inactive Publication Date: 2018-01-09
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When liposome solution is used to treat skin wounds, because of its strong fluidity, it is ea

Method used

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  • Madecassoside liposomal gel for local external application and preparation method thereof
  • Madecassoside liposomal gel for local external application and preparation method thereof
  • Madecassoside liposomal gel for local external application and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0043] Example 1

[0044] (1) Preparation of madecassoside liposome solution: weigh 0.50g egg yolk lecithin, 0.10g cholesterol, 0.1g VE acetate and dissolve it in 10mL dichloromethane to prepare an organic solution; remove organic solvent by rotary evaporation To form a film, add 20mg / mL madecassoside solution to the film, add appropriate amount of glass beads and stir at 50℃ for 1h, ultrasonic probe for 30min, and then pass through a 0.22μm aqueous filter membrane to obtain madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 22.22%, and the mass of egg yolk lecithin accounts for 55.56%.

[0045] (2) Preparation of blank gel: Add 0.1g of azone and 1.5g of propylene glycol with mass fraction of 8mL of water, and then add 0.2g of sodium carboxymethylcellulose, and stir well to obtain a blank gel.

[0046] (3) Add 2 mL of the madecassoside liposome solution in step (1) to the blank gel in step (2), stir well, and adjust the pH...

Example Embodiment

[0048] Example 2

[0049] (1) Preparation of madecassoside liposome solution: Weigh 0.50 g egg yolk lecithin, 0.10 g cholesterol, and 0.1 g VE acetate, dissolve them in 10 mL ethanol to prepare an organic phase solution; separate the above organic phase solution Adding 15mg / mL madecassoside solution dropwise, stirring while dropping until the solvent is removed, and pass through a 0.22μm oily filter membrane to obtain madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 17.65%, and the mass of egg yolk lecithin accounts for 58.82%.

[0050] (2) Preparation of a blank gel: add 0.1g of azone and 2.0g of propylene glycol with a mass fraction of 7.5mL of water, and then add 0.4g of sodium carboxymethyl cellulose, fully stir to obtain a blank gel.

[0051] (3) Add 2.5 mL of the madecassoside liposome solution in step (1) to the blank gel in step (2), and adjust the pH to 7 with 7% NaOH solution to obtain madecassoside Plastid ge...

Example Embodiment

[0053] Example 3

[0054] (1) Preparation of madecassoside liposome solution: weigh 0.50g egg yolk lecithin, 0.10g cholesterol, 0.1g VE acetate and dissolve it in 10mL dichloromethane to prepare an organic solution; remove organic solvent by rotary evaporation To form a film, add 10mg / mL madecassoside solution to the film, rotate and hydrate to obtain liposome solution, add 0.005g mannitol, mix well, freeze-dry in vacuum, shake the liposome lyophilized powder with PBS Shake and disperse to obtain madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 12.42%, and the mass of egg yolk lecithin accounts for 62.11%.

[0055] (2) Preparation of blank gel: Add 0.1g of azone and 1.8g of propylene glycol with mass fraction of 7mL of water, and then add 0.6g of sodium carboxymethyl cellulose, fully stir to obtain a blank gel.

[0056] (3) Add 2 mL of the madecassoside liposome solution in step (1) to the blank gel in step (2), and adj...

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Abstract

The invention discloses a madecassoside liposomal gel for local external application and a preparation method thereof. The liposomal gel is mainly prepared from a madecassoside liposomal, a gel and ultrapure water, wherein the liposomal is provided with a bilayer structure; madecassoside is encapsulated into the liposomal; the mass of the madecassoside liposomal accounts for 1 to 60 percent of thetotal mass of the liposomal gel, and the mass of the gel accounts for 1 to 30 percent of the total mass of the liposomal gel. The liposomal gel has the characteristic of a semi-solid gel state, the drug has a better fitting effect on a wound, the administration time is ensured, a better drug delayed release effect is achieved, a better antisepsis and anti-inflammation effect is achieved, and themadecassoside liposomal gel is beneficial for healing the wound and has no stimulation on skins so as to be high efficient and safe; the liposomal can be promoted to effectively permeate through the skins, so that more madecassoside components can stay in a corium layer, and a drug effect is more remarkable. The madecassoside liposomal gel can be used as an excellent slow release preparation for repairing scars and promoting wound healing.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and skin care products, and in particular relates to a locally applied madecassoside liposome gel, a preparation method thereof and an application in treating scars. Background technique [0002] Madecassoside is one of the main triterpenoid saponins in Centella asiatica (L.) Urban. Madecassoside has a wide range of pharmacological activities such as anti-inflammation, anti-oxidation, and promotion of wound healing. It is used to treat skin injuries, burns and scalds, and repair scars. Due to the characteristics of its polar macromolecules, madecassoside is difficult to directly penetrate the stratum corneum and epidermis of the skin. [0003] Liposomes are cell membrane-like spherical bodies composed of phospholipid bilayers. The interior of the liposome can encapsulate various fat-soluble or water-soluble drugs, thereby improving the stability and utilization of the drug. Liposomes ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/127A61K31/7024A61K47/38A61K47/36A61P17/02A61K8/63A61K8/14A61K8/04A61Q19/00
Inventor 刘美凤鄢豪曾嘉达
Owner SOUTH CHINA UNIV OF TECH
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