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A preparation method of physically cross-linked chitosan-based hydrogel with high pH sensitivity and high mechanical strength

A technology of mechanical strength and physical cross-linking, which is applied in the field of preparation of physically cross-linked chitosan-based hydrogels, can solve the problems of slow response to external stimuli and poor mechanical properties, and achieve easy mixing and heat dissipation, and strong mechanical properties , the effect of mild reaction conditions

Inactive Publication Date: 2019-07-26
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of slow response to external stimuli and poor mechanical properties in current pH-sensitive physical cross-linked hydrogels, the purpose of the present invention is to provide a novel preparation method of pH-sensitive physical hydrogels. On the premise of adding chemical crosslinking agent, the pH sensitivity and mechanical strength of the obtained hydrogel are greatly improved

Method used

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  • A preparation method of physically cross-linked chitosan-based hydrogel with high pH sensitivity and high mechanical strength
  • A preparation method of physically cross-linked chitosan-based hydrogel with high pH sensitivity and high mechanical strength
  • A preparation method of physically cross-linked chitosan-based hydrogel with high pH sensitivity and high mechanical strength

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Embodiment 1

[0035] The preparation of the physically cross-linked chitosan-based hydrogel with efficient pH sensitivity and high mechanical strength shown in embodiment 1. formula (I)

[0036] In step (1), at room temperature, 1.0 g of chitosan represented by formula (III) was dissolved in 10 mL of 1% acetic acid solution by mass fraction, and stirred overnight to prepare a transparent chitosan solution.

[0037] Step (2), add the monomer DMAEMA shown in the formula (II) and the monomer AAC shown in the formula (IV) (mass ratio is 2.5:97.5) into the round bottom flask, mix in 0 ℃ (ice-water bath) uniform.

[0038] Step (3), adding the potassium persulfate-sodium thiosulfate redox initiator with a mass concentration of 0.16% in the step (1) system, then adding the monomer mixture obtained in step (2), stirring evenly with a magnet and passing through Deoxygenate with nitrogen for 15 minutes.

[0039] In step (4), the reaction mixture prepared in step (3) is poured into a small test tube ...

Embodiment 2

[0043] Embodiment 2. As described in Example 1, the difference is that the quality of chitosan shown in the change formula (III) is 2g, the swelling ratio of the gel becomes 16.43, and the maximum compressive strength becomes 0.0326MPa.

Embodiment 3

[0044] Embodiment 3. As described in Example 1, the difference is that the mass ratio of monomer DMAEMA shown in changing formula (II) and monomer AAC shown in formula (IV) is 5:95, and the swelling rate of gel becomes 22.79, and the maximum compressive strength becomes 0.1309MPa.

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Abstract

The preparation method of the physically cross-linked chitosan-based hydrogel with high-efficiency pH sensitivity and high mechanical strength represented by the formula (I) belongs to the technical field of polymer functional modification synthesis of natural materials. With the hydroxyl group on the surface of chitosan shown in formula (III) as the grafting site, the chemical initiator potassium persulfate-sodium thiosulfate is thermally decomposed to generate free radicals, forming active points on chitosan, further triggering a part of the formula The monomer AAC shown in (IV) and the monomer DMAEMA shown in the formula (II) are graft-polymerized on the chitosan main chain, and the copolymer molecular chains of two kinds of monomers are obtained simultaneously, interspersed in the chitosan graft The macromolecular chains of the copolymer form a semi-interpenetrating network to obtain the hydrogel shown in formula (I), and the product is freeze-dried to obtain a solid product, and the reaction is easy to operate and the conditions are mild. The physical crosslinked hydrogel obtained by the preparation method has high pH sensitivity and high mechanical strength, and has good biocompatibility and large swelling rate at the same time, and is used in the separation of macromolecular solutes and drug release systems in the medical and pharmaceutical fields. It has broad application prospects in aspects such as diagnosing diseases and daily monitoring.

Description

technical field [0001] The invention relates to a preparation method of a physically cross-linked chitosan-based hydrogel with high-efficiency pH sensitivity and high mechanical strength, and belongs to the technical field of functional modification of natural polymer materials. Background technique [0002] Due to its unique responsiveness, smart hydrogels have broad application prospects in sensors, drug delivery, tissue engineering, and enzyme immobilization. , electric field, solvent properties, light intensity and light wavelength, pressure, ionic strength, etc.) The properties of the gel change accordingly, among which the pH-responsive hydrogel is the most important and most widely studied intelligent hydrogel Glue one. [0003] pH-sensitive hydrogels can change properties (such as swelling degree, shape, etc.) with the change of external pH value, and usually contain ionizable acidic or basic groups on the polymer chain of the gel, such as carboxyl, Sulfonic acid g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F220/06C08F220/34C08F2/10
Inventor 车玉菊孟凡君李冬平其他发明人请求不公开姓名
Owner SHANDONG UNIV