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Externally used patch for treating rib-side pain, depressed liver, deficient spleen and blood stasis syndrome caused by chronic liver disease

A technology for hypochondriac pain, liver depression and spleen deficiency, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problems of increasing the burden on the liver, affecting the quality of life of patients, and lack of drugs, etc. Achieve good hepatosplenomegaly, meet modern medical needs, and achieve high drug penetration

Inactive Publication Date: 2018-02-02
HENAN UNIV HUAIHE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

affect the patient's quality of life
[0003] At present, the clinical treatment of this disease is mostly oral medicine, which also increases the burden on the liver while treating liver disease, and there is a lack of drugs with better therapeutic effects. Therefore, it is particularly important to develop new Chinese medicines that relieve pain and improve the quality of life of patients.

Method used

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  • Externally used patch for treating rib-side pain, depressed liver, deficient spleen and blood stasis syndrome caused by chronic liver disease
  • Externally used patch for treating rib-side pain, depressed liver, deficient spleen and blood stasis syndrome caused by chronic liver disease
  • Externally used patch for treating rib-side pain, depressed liver, deficient spleen and blood stasis syndrome caused by chronic liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The clinical research of embodiment 1 Liver Disease Patch (compared with Xiaoyao Pill)

[0026] 1. Diagnostic criteria and TCM syndrome differentiation

[0027] The method of focusing on disease and combining disease and syndrome is based on the "Guiding Principles of Clinical Research of Traditional Chinese Medicine (New Drugs)" (formulated by the Ministry of Health in 1993) and "National Viral Hepatitis Prevention and Control Program" (formulated at the Xi'an Conference in 2000), which is in line with the diagnosis of chronic hepatitis Standard, with typical unilateral or bilateral flank pain symptoms. According to the "Guiding Principles for Clinical Trials of New Chinese Medicines" (promulgated by the Ministry of Health in 1993), TCM syndromes belong to syndrome of liver depression and spleen deficiency combined with blood stasis. .

[0028] 2. Treatment

[0029] Treatment group: select Ganshu plaster of the present invention, paste on the hypochondrium pain site...

Embodiment 2

[0065] The preparation technology of embodiment 2 liver disease plaster and the research of preparation auxiliary material

[0066] Liver disease plaster is a hot-melt (SIS medical resin glue) resin plaster, which has a good affinity for medium and low polar compounds. The matrix used is mainly made of SIS, mixed with vinyl chloride resin, konjac powder, spermaceti, caproic acid and other auxiliary materials, and then the formulation of the matrix and the main drug is studied to form a plaster preparation for external use. The development of this kind of matrix compatibility is based on the study of rubber paste preparations, using medical hot-melt adhesives instead of rubber to avoid the use of gasoline, thereby improving production safety and reducing labor intensity, and making the production process and facilities meet GMP requirements.

[0067] Preparation method: heat and dissolve hot-melt styrene-ethylene-butylene-styrene block copolymer medical adhesive, add viscosity ...

Embodiment 3

[0079] The composition of the external patch is as follows:

[0080] 15 parts of Achyranthes bidentata, 10 parts of coix seed, 6 parts of Moutan bark, 8 parts of motherwort, 7 parts of myrrh, 5 parts of comfrey, 3 parts of mugwort leaves, 4 parts of Patrinia, 5 parts of Miltonia Spatholobus, and mountain alum leaves 3 parts, 3 parts of geranium, 2 parts of rice field eel vine root

[0081] This external patch is made by following method:

[0082] 1) Preparation of CO2 supercritical extracts of Cortex Moutan, Myrrha, Mildew Spatholobus, and Eel Vine Roots: Mix Cortex Moutan, Mildew Spatholobus, and Eel Vine Roots, mix them, grind them through a 30-mesh sieve, and pass through a CO2 2 Supercritical extraction, the extraction temperature is 45-52°C, the pressure is 10-30Mpa, and the extract is collected;

[0083] 2) Prepare the extract obtained by co-extracting Achyranthes bidentata, Coix seed, Moutan cortex, Motherwort, Myrrh, Comfrey, Artemisia argyi, Patrinia, Caulis Spathol...

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Abstract

The invention relates to an externally used patch for treating rib-side pain, depressed liver, deficient spleen and blood stasis syndrome caused by a chronic liver disease. The externally used patch is characterized by being prepared from the following raw materials: 15 to 25 parts of radix achyranthis bidentatae, 10 to 15 parts of semen coicis, 6 to 12 parts of cortex moutan, 8 to 16 parts of polygonum chinense, 7 to 10 parts of myrrh, 5 to 8 parts of radix arnebiae seu lithospermi, 3 to 5 parts of folium artemisiae argyi, 4 to 8 parts of herba patriniae, 5 to 9 parts of caulis spatholobi, 3to 5 parts of folium symplocos caudate, 3 to 6 parts of purple senecio and 2 to 4 parts of radix berchemia floribunda. The liver disease patch provided by the invention has the advantages of simplicity, feasibility, low toxic or side effect, quick response, capacity of avoiding an activating effect of digestive tract and liver digestive enzymes, and the like. Traditional medicament administrationis inherited, and meanwhile, the advantages of the traditional meridian and collateral theory and an advanced preparation technology are combined, and cutaneous penetration and acupuncture point functions are combined, so that the treatment effect is beneficially improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to an external patch for treating hypochondrium pain caused by chronic liver disease with liver depression, spleen deficiency and blood stasis syndrome. Background technique [0002] Liver disease is a common disease and a frequently-occurring disease in my country. In my country, there are about hundreds of millions of people infected with hepatitis virus, and there are 30 million patients with chronic hepatitis, which seriously affects people's health. Hypochondriac pain refers to a disease mainly manifested by pain in one or both sides of the hypochondriac. It is one of the common clinical symptoms of chronic liver disease. Its pathogenesis is mainly stagnation of Qi due to depression of the liver, unfavorable catharsis, and loss of nourishment of the meridians. "Internal Classics" says: "When the evil is in the liver, it causes pain in the hypochondriac." In Chinese...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/70A61P1/16A61P29/00
CPCA61K9/7053A61K9/7076A61K36/185A61K36/21A61K36/28A61K36/282A61K36/30A61K36/328A61K36/486A61K36/65A61K36/704A61K36/71A61K36/72A61K36/84A61K36/8994A61K2236/333A61K2236/37A61K2236/39A61K2300/00
Inventor 贺志宽
Owner HENAN UNIV HUAIHE HOSPITAL
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