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Surface modification method for implant materials of biomedical active titanium and alloy of biomedical active titanium

An alloy and modification technology, applied in the field of biomedical engineering, can solve the problems of many barriers, difficulty in rapid clinical application, complicated clinical approval process, etc., and achieve the effect of simple process, favorable calcium and phosphorus deposition, and inhibition of bacterial infection.

Active Publication Date: 2018-02-16
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But adding metal ions, the clinical approval process is complicated, there are many barriers, and it is difficult to quickly apply to clinical practice
There are also chemical methods to load functional proteins for early and rapid osseointegration, but they have not fundamentally solved the problem of loosening after long-term implantation

Method used

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  • Surface modification method for implant materials of biomedical active titanium and alloy of biomedical active titanium
  • Surface modification method for implant materials of biomedical active titanium and alloy of biomedical active titanium
  • Surface modification method for implant materials of biomedical active titanium and alloy of biomedical active titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Ultrasonic treatment of titanium sheets

[0098] Put vacuum-packed sandblasted acid-etched (SLA) titanium metal sheets with a diameter of 10 mm and a thickness of 1 mm into 100 ml of clarified 5M NaOH just prepared. The small air bubbles on the titanium surface are spilled under ultrasound. Perform ultrasonication for 5 minutes, wrap the cap of the iodine bottle with plastic wrap, and cover it to prevent the long-term sealing from sticking together and making it difficult to open. Put it into a constant temperature drying oven at 60°C and let it stand for 24 hours.

[0099] Take out the titanium sheet and put it into a disposable plastic cup, add an appropriate amount of ultrapure water to wash it repeatedly for 3 times, and then perform ultrasonic cleaning. Put the cleaned titanium sheet on the filter paper prepared in advance, put it into a petri dish, and slowly dry it at 37°C for 48 hours.

[0100] The titanium sheet was taken out and put into a crucible, heated ...

Embodiment 2

[0105] calcium phosphate precipitation

[0106] The vacuum-packed sandblasted acid-etched (SLA) titanium sheet with a diameter of 10 mm and a thickness of 1 mm was put into 100 ml of clarified 6M NaOH just prepared. The small air bubbles on the titanium surface are spilled under ultrasound. Ultrasound for 10 minutes until the air bubbles are removed, wrap the cap of the iodine bottle with plastic wrap and cover it. Put it into a constant temperature drying oven at 60°C and let it stand for 24 hours.

[0107] Take out the titanium sheet and put it into a disposable plastic cup, add an appropriate amount of ultrapure water to wash it repeatedly for 3 times, and then perform ultrasonic cleaning. Put the cleaned titanium sheet on the filter paper prepared in advance, put it into a petri dish, and slowly dry it at 37°C for 48 hours.

[0108] The titanium sheet was taken out and put into a crucible, heated to 600° C. for 1 hour under the protection of nitrogen at 3° C. / min and ca...

Embodiment 3

[0113] Self-assembled modified titanium sheets

[0114] Put vacuum-packed sandblasted acid-etched (SLA) titanium metal sheets with a diameter of 10 mm and a thickness of 1 mm into 100 ml of clarified 5M NaOH just prepared. The small air bubbles on the titanium surface are spilled under ultrasound. Ultrasound for 10 minutes until the air bubbles are removed, wrap the cap of the iodine bottle with plastic wrap and cover it. Put it into a constant temperature drying oven at 60°C and let it stand for 24 hours.

[0115] Take out the titanium sheet and put it into a disposable plastic cup, add an appropriate amount of ultrapure water to wash it repeatedly for 3 times, and then perform ultrasonic cleaning. Put the cleaned titanium sheet on the filter paper prepared in advance, put it into a petri dish, and slowly dry it at 37°C for 48 hours.

[0116] The titanium sheet was taken out and put into a crucible, heated to 600° C. for 1 hour under the protection of nitrogen at 3° C. / min...

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Abstract

The invention discloses a surface modification method for implant materials of biomedical active titanium and alloy of the biomedical active titanium. The improved titanium or alloy of the improved titanium comprises a titanium or titanium alloy substrate, and 1-16 self-assembly layers arranged on the surface of the titanium or titanium alloy substrate, wherein the self-assembly layers are tannicacid / gentamicin self-assembly layers, tannic acid / chitosan self-assembly layers or tannic acid / bovine serum albumin self-assembly layers. The titanium or titanium alloy substrate is placed in alkali liquor, micro-nano etching is carried out under the ultrasonic condition, thus a micro-nano structure is obtained, tannic acid and gentamicin are assembled on a micro-nano structure by utilizing the layer-by-layer self-assembly technology, and thus modification is carried out on the surface of titanium or titanium alloy. The method provided by the invention is simple in process, and convenient to operate. The biomedical active titanium and alloy of the biomedical active titanium prepared by adopting the method can effectively inhibit the infection of bacteria, and are used for replacing the hard tissue, and the clinical success rate can be improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and relates to a method for creating a micro-nano structure on the surface of a medical device implant and a micro-nano antibacterial modification method, more specifically, to a bacteriostatic antimicrobial agent for hard tissue repair. Surface antibacterial modification method of biomedical active titanium and its alloy implant materials. Background technique [0002] Due to its excellent biocompatibility, corrosion resistance and comprehensive mechanical properties, titanium alloy has gradually become the material of choice for human hard tissue substitutes and restorations such as dental implants, orthopedic trauma products, and artificial joints, but there are still implant failures. question. [0003] Long-term clinical and research studies have found that there are two main reasons for the failure of implants at this stage: the biological activity of implants is not ideal, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/34A61L27/06A61L27/50A61L27/54C23F1/38
CPCA61L27/06A61L27/28A61L27/34A61L27/50A61L27/54A61L2300/404A61L2300/412A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02A61L2430/12A61L2430/24C23F1/38C08L5/08
Inventor 刘昌胜乔忠乾何宏燕
Owner EAST CHINA UNIV OF SCI & TECH
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