Vitamin complex tablets and preparation method thereof

A technology for multivitamins and vitamins, applied in the field of multivitamin tablets and their preparation, can solve the problems of large content difference and uneven mixing of raw materials of multivitamin tablets, so as to improve the dissolution rate, improve drug stability, and drug dissolution rate, disintegration and disintegration. The effect of shortening the solution time limit

Inactive Publication Date: 2018-03-09
NANJING ZHULU PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a compound vitamin tablet and a preparation method thereof, which solves the problems of uneven mixing of raw materials and large content differences in existing compound vitamin tablets

Method used

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  • Vitamin complex tablets and preparation method thereof
  • Vitamin complex tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The present embodiment provides a kind of multivitamin tablet, is made up of the following components by weight: vitamin A palmitate 4.40g, vitamin B 1 1.60g, vitamin B 2 Powder 5.42g, Vitamin B 6 2.60g, vitamin B 12 0.004g, vitamin C calcium 121g, vitamin D 3 5.0g vitamin E acetate powder, 30.0g vitamin E acetate powder, 20.0g biotin powder, 0.80g folic acid, 19.0g nicotinamide, 10.0g calcium pantothenate, 465.56g calcium hydrogen phosphate, 3.90g copper sulfate, 181.67 ferrous fumarate g, magnesium hydrogen phosphate 211.35g, magnesium oxide 118.86g, manganese sulfate 3.08g, zinc sulfate 33.18g, magnesium stearate 7.5g, microcrystalline cellulose 30.0g, lactose 30.0g and mannitol 30.0g, povidone K30 45g, sodium carboxymethyl starch 75g, gastric soluble coating powder 32g;

[0025] The vitamin A palmitate is made by mixing 90 parts by weight of vitamin A palmitate, 5 parts by weight of butyl hydroxyanisole, and 5 parts by weight of dibutyl hydroxytoluene;

[0026...

Embodiment 2

[0032] The present embodiment provides a kind of multivitamin tablet, is made up of the following components by weight: vitamin A palmitate 4.40g, vitamin B 1 1.60g, vitamin B 2 Powder 5.42g, Vitamin B 6 2.60g, vitamin B 12 0.004g, vitamin C calcium 121g, vitamin D 3 5.0g vitamin E acetate powder, 30.0g vitamin E acetate powder, 20.0g biotin powder, 0.80g folic acid, 19.0g nicotinamide, 10.0g calcium pantothenate, 465.56g calcium hydrogen phosphate, 3.90g copper sulfate, 181.67 ferrous fumarate g, magnesium hydrogen phosphate 211.35g, magnesium oxide 125.86g, manganese sulfate 3.08g, zinc sulfate 33.18g, talcum powder 7.5g, lactose 30g, pregelatinized starch 30g, binder 45g, disintegrant 75g, gastric soluble bag Clothing powder 36g;

[0033] The vitamin A palmitate is made by mixing 92 parts by weight of vitamin A palmitate and 4 parts by weight of butyl hydroxyanisole and 4 parts by weight of dibutyl hydroxytoluene;

[0034] The vitamin D 3 is composed of 5 parts by weig...

Embodiment 3

[0040] The present embodiment provides a kind of multivitamin tablet, is made up of the following components by weight: vitamin A palmitate 4.40g, vitamin B 1 1.60g, vitamin B 2 Powder 5.42g, Vitamin B 6 2.60g, vitamin B 12 0.004g, vitamin C calcium 121g, vitamin D 3 5.0g vitamin E acetate powder, 30.0g vitamin E acetate powder, 20.0g biotin powder, 0.80g folic acid, 19.0g nicotinamide, 10.0g calcium pantothenate, 465.56g calcium hydrogen phosphate, 3.90g copper sulfate, 181.67 ferrous fumarate g, magnesium hydrogen phosphate 211.35g, magnesium oxide 125.86g, manganese sulfate 3.08g, zinc sulfate 33.18g, magnesium stearate 7.5g, lactose 60g, carboxymethylcellulose sodium 45g, disintegrant 75g, gastric soluble coating Powder 30g;

[0041] The vitamin A palmitate is made by mixing 95 parts by weight of vitamin A palmitate, 3 parts by weight of butyl hydroxyanisole, and 2 parts by weight of dibutyl hydroxytoluene;

[0042] The vitamin D 3 Consists of 3 parts by weight of v...

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Abstract

The invention discloses vitamin complex tablets and a preparation method thereof. The vitamin complex tablets are prepared from the following components of vitamin A palmitate, vitamin B1, vitamin B2powder, vitamin B6, vitamin B12, calcium ascorbate, vitamin D3 powder, vitamin E acetic ester powder, biotin trituration, folic acid, nicotinamide, calcium pantothenate, dicalcium phosphate, copper sulfate, ferrous fumarate, magnesium hydrogen phosphate, magnesium oxide, manganese sulfate, zinc sulfate, a lubricant, a filling agent, an adhesive, a disintegrant and gastric-soluble coating powder. According to the preparation method of the vitamin complex tablets disclosed by the invention, a fluidized bed granulation production technology and a dry powder granulation production technology are adopted, so that the problem that main components are degraded caused by high-temperature drying in a conventional wet-method granulation technology is solved, besides, the technical difficult problemsof uneven mixing of various vitamins, low dissolution rate and slow disintegration time caused by a conventional production technology are also solved, and the medicine stability and the medicine dissolution rate are increased.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a compound vitamin tablet and a preparation method thereof. Background technique [0002] Multivitamin Tablets (Vitamin Complex Tablets) produced by Bayer HealthCare Co., Ltd. is used for the additional needs of vitamins, minerals and trace elements during pregnancy and breastfeeding women, and to prevent anemia caused by iron and folic acid deficiency during pregnancy The drug containing 12 kinds of vitamins and 7 kinds of trace minerals, whose trade name is ( Pronatal). Multivitamin tablets have been widely used in clinical practice for many years. Clinical trials have shown that this product has definite curative effect and fewer adverse reactions. Unstable, the conventional wet mixing granulation or dry powder mixing granulation production process often leads to uneven mixing of raw and auxiliary materials, large content differences, unstable quality, and long ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L33/155A23L33/10A23L33/16A23L33/12A23L29/30A23P10/20
CPCA23V2002/00A23V2200/30A23V2250/1578A23V2250/1592A23V2250/1612A23V2250/1588A23V2250/1642A23V2250/702A23V2250/7044A23V2250/706A23V2250/7056A23V2250/7106A23V2250/712
Inventor 张正艮石向荣戴荣娟
Owner NANJING ZHULU PHARMA TECH
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