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PCL/HA composite porous bone tissue engineering scaffold and preparation method thereof

A tissue engineering scaffold and porous bone technology, which can be applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of slow degradation rate and high brittleness, and achieve good degradation performance, no biotoxicity, and excellent biocompatibility Effect

Inactive Publication Date: 2018-03-23
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical composition of hydroxyapatite (HA) is similar to that of natural bone inorganic minerals, it has good biocompatibility, osteoconductivity and fusion, and relatively high mechanical strength, but its brittleness is too large and the degradation rate is too slow. its application in bone tissue engineering

Method used

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  • PCL/HA composite porous bone tissue engineering scaffold and preparation method thereof
  • PCL/HA composite porous bone tissue engineering scaffold and preparation method thereof
  • PCL/HA composite porous bone tissue engineering scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: The PCL / HA composite porous bone tissue engineering scaffold in this example is composed of polycaprolactone and hydroxyapatite. In terms of mass percentage, the content of hydroxyapatite is 0.5%, and the rest is polycaprolactone; Among them, the porosity of the scaffold is 89.4%, the diameter of the irregular through-holes is 10-300μm, and the compressive strength is 0.98Mpa;

[0025] (1) Dissolve polycaprolactone in an organic solvent (the organic solvent is dichloromethane), then add a pore-forming agent (the pore-forming agent is sodium bicarbonate) at room temperature and disperse evenly under stirring conditions to obtain Mixture A; wherein the solid-to-liquid ratio g:mL of polycaprolactone to the organic solvent is 1:10, and the solid-to-liquid ratio g:mL of the pore-forming agent (sodium bicarbonate) to the organic solvent is 1:1;

[0026] (2) Add hydroxyapatite to the mixture A obtained in step (1) at room temperature and disperse evenly under stirri...

Embodiment 2

[0037] Example 2: The PCL / HA composite porous bone tissue engineering scaffold in this example is composed of polycaprolactone and hydroxyapatite. In terms of mass percentage, the content of hydroxyapatite is 10%, and the rest is polycaprolactone; Among them, the porosity of the scaffold is 65.5%, the diameter of the irregular through-holes is 10-300μm, and the compressive strength is 2.48Mpa;

[0038] (1) Dissolve polycaprolactone in an organic solvent (the organic solvent is chloroform), then add a pore-forming agent (the pore-forming agent is sodium carbonate) at a temperature of 45°C and disperse evenly under stirring conditions to obtain Mixture A; wherein the solid-to-liquid ratio g:mL of polycaprolactone to the organic solvent is 1:6, and the solid-to-liquid ratio g:mL of the pore-forming agent (sodium carbonate) to the organic solvent is 1:1;

[0039] (2) At a temperature of 55°C, add hydroxyapatite to the mixture A obtained in step (1) and disperse evenly under stirri...

Embodiment 3

[0050] Example 3: The PCL / HA composite porous bone tissue engineering scaffold in this example is composed of polycaprolactone and hydroxyapatite whiskers. In terms of mass percentage, the content of hydroxyapatite is 50%, and the rest is polycaprolactone Ester; the porosity of the scaffold is 10%, the diameter of the irregular through-holes is 10-300μm, and the compressive strength is 10.20Mpa;

[0051] (1) Dissolve polycaprolactone in an organic solvent (the organic solvent is a mixture of chloroform and carbon tetrachloride), and then add a pore-forming agent at a temperature of 80°C (the pore-forming agent is potassium carbonate (K 2 CO 3 ) and potassium bicarbonate (KHCO 3 ) mixture) and uniformly disperse under stirring conditions to obtain mixture A; wherein the solid-liquid ratio g:mL of polycaprolactone and organic solvent is 1:5, and the solid-liquid ratio g:mL of pore-forming agent and organic solvent is 1 :1;

[0052] (2) At a temperature of 80°C, add hydroxyapa...

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Abstract

The invention discloses a PCL / HA composite porous bone tissue engineering scaffold and a preparation method thereof, and belongs to the field of technical application of biomedical materials. The scaffold comprises, by mass, 0.5-50% of hydroxyapatite, and the balance of polycaprolactone, wherein the porosity of the scaffold is 10-89.4%, the pore diameter is 10-600 [mu]m, and the compressive strength is 0.98-10.20 Mpa. The PCL / HA composite porous bone tissue engineering scaffold has qualified cytotoxicity and good clinical application prospects; and the preparation method of the scaffold has the advantages of simple process flow, convenience in operation, and stable yield.

Description

technical field [0001] The invention relates to a PCL / HA composite porous bone tissue engineering scaffold and a preparation method thereof, belonging to the technical application field of biomedical materials. Background technique [0002] Tissue engineering is a discipline that aims to restore the functional role of various organs through regeneration and formation of new tissues. Bone tissue engineering is a branch of tissue engineering, mainly to study bone regeneration and bone repair and reconstruction. Bone defects often occur after trauma, tumors and other diseases. The previous treatment method was autologous or allogeneic bone transplantation, but the emergence of bone tissue engineering has changed the treatment method for bone defect regeneration and repair. The three-dimensional internal pore structure of the scaffold material can meet the application of bone tissue engineering, because this structure can provide sufficient space for the adhesion and growth of ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/58
CPCA61L27/46A61L27/56A61L27/58A61L2430/02C08L67/04
Inventor 颜廷亭秦晓素郭华超陈庆华
Owner KUNMING UNIV OF SCI & TECH
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