Preparation method of high-purity flurbiprofen known impurities
A flurbiprofen and impurity technology, which is applied in the preparation of organic compounds, carboxylates, carboxylates, etc., can solve problems such as no preparation impurities, and achieve improved drug safety, easy operation, and purity. high effect
Active Publication Date: 2018-04-20
北京茗泽中和药物研究有限公司
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Abstract
The invention discloses a preparation method of high-purity flurbiprofen known impurities B. The preparation method comprises the following steps: enabling a tetrahydrofuran solution of 4-bromine-2-fluorobiphenyl as a starting material to perform Grignard reaction with magnesium, acidifying after coupled docking with side chain 2-bromo-2,3-sodium dimethyl succinate, preparing crude products of flurbiprofen impurities and performing re-crystallization on the high-purity flurbiprofen known impurities B, namely 2-(2-fluoro-4-biphenyl)-2,3-dimethylidene succinic acids. The preparation method disclosed by the invention is simple and convenient to operate, short in reaction time, high in product purity, high in yield and suitable for industrial production. The synthesized impurities B can be used for the qualitative and quantitative analysis on the impurities, so that the drug use safety of flurbiprofen is improved.
Application Domain
Preparation from carboxylic acid saltsOrganic compound preparation +3
Technology Topic
Grignard reactionBromine +13
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