Preparation method for injection grade medicinal sodium bicarbonate
A technology of sodium bicarbonate and sodium carbonate, which is applied in bicarbonate preparation, pharmaceutical formula, alkali metal carbonate, etc., can solve the problems of unsuitable for small-scale production, unsuitable for industrial production, high process production cost, and achieve Low production cost, simplified production process, good fluidity
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Embodiment 1
[0015] Under the temperature condition of 25°C and the stirring speed of 25r / min, add 250g of sodium carbonate raw powder into 1000mL of distilled water until the sodium carbonate is completely dissolved, the solution is filtered through membrane, the air in the device is removed, and CO is introduced into the reaction device 2 , so that the internal pressure reached 0.01MPa, stirred and reacted at this temperature and pressure for 4h, after the reaction was completed, the crystal slurry was filtered and washed to obtain a wet crude product of sodium bicarbonate. Dissolve the wet crude product in 600mL distilled water, filter, and concentrate the filtrate under reduced pressure at 30°C and -0.04MPa vacuum until a small amount of white crystals precipitate, stop the concentration, crystallize at room temperature for 8h, filter, wash, and store at 30°C After drying for 6 hours, 201.5 g of the final sodium bicarbonate product was obtained, with a yield of 80.6%. The content is 10...
Embodiment 2
[0021] At a temperature of 28°C and a stirring speed of 35r / min, add 225g of sodium carbonate raw powder into 800mL of distilled water until the sodium carbonate is completely dissolved, the solution is filtered through a membrane, the air in the device is removed, and CO is introduced into the reaction device 2 , so that the internal pressure reached 0.02MPa, stirred and reacted at this temperature and pressure for 3h, after the reaction was completed, the magma was filtered and washed to obtain a wet crude product of sodium bicarbonate. Dissolve the wet crude product in 750mL distilled water, filter, and concentrate the filtrate under reduced pressure at 32°C and -0.05MPa vacuum until a small amount of white crystals precipitate, stop the concentration, crystallize at room temperature for 6h, filter, wash, and store at 35°C Drying under high temperature for 4 hours gave 202.8 g of refined sodium bicarbonate with a yield of 81.12%. With reference to the test method of Example...
Embodiment 3
[0023] At a temperature of 30°C and a stirring speed of 40r / min, add 310g of sodium carbonate raw powder into 1200mL of distilled water until the sodium carbonate is completely dissolved, the solution is filtered through a membrane, the air in the device is removed, and CO is introduced into the reaction device 2 , so that the internal pressure reached 0.03MPa, stirred and reacted at this temperature and pressure for 2h, after the reaction was completed, the magma was filtered and washed to obtain a wet crude product of sodium bicarbonate. Dissolve the wet crude product in 800mL distilled water, filter, and concentrate the filtrate under reduced pressure at 25°C and -0.07MPa vacuum until a small amount of white crystals precipitate, stop the concentration, crystallize at room temperature for 5h, filter, wash, and store at 35°C After drying for 4 hours, 258.9 g of refined sodium bicarbonate was obtained, with a yield of 83.51%. With reference to the test method of Example 1, th...
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