Method for synthesizing glutaric acid from alpha-ketoglutaric acid
A technology of ketoglutaric acid and glutaric acid is applied in the field of preparation of glutaric acid, which can solve the problems of not conforming to the concept of sustainable development of green chemistry, expensive raw material sources, difficult to synthesize and use in large quantities, etc. The effect of safe conditions and mild reaction conditions
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[0031] specific implementation
[0032] In order to understand the present invention, the present invention will be further described below in conjunction with embodiment: following embodiment is illustrative, not limiting, can not limit protection scope of the present invention with following embodiment.
[0033] A method for the synthesis of glutaric acid from alpha-ketoglutaric acid, the steps are as follows:
[0034] 1. Compound 1 (N 1 ,N 1 ,N 5 ,N 5 -tetraethyl-2-oxopentanediamide) synthesis.
[0035]
[0036] Add α-ketoglutaric acid (10.00g, 68.45mmol) and thionyl chloride (15.00ml, 205.34mmol) to a round bottom flask, and place the reaction mixture under reflux for one hour at 80°C. Pressure distilled to dark brown viscous oily liquid. After dissolving in tetrahydrofuran (20.00 ml), diethylamine was slowly added dropwise to the above mixture at a temperature of -10°C, and the reaction was continued overnight at room temperature with stirring. After the reactio...
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