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Branched polyamino acid bacteriostat and application

A technology of polyamino acid and bacteriostatic agent, applied in the direction of application, bactericide, antifungal agent, etc.

Inactive Publication Date: 2018-06-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of branched polyamino acid in the antibacterial field has not been reported so far

Method used

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  • Branched polyamino acid bacteriostat and application
  • Branched polyamino acid bacteriostat and application
  • Branched polyamino acid bacteriostat and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Add 100 grams of arginine into a 500 mL round-bottomed flask, connect the water separator, and pump and replace nitrogen three times for more than 10 minutes each time. Finally, keep a nitrogen atmosphere, stir and heat at 180 ° C for 4 hours, stop heating, and then the reaction system After cooling to room temperature, the polymer was dissolved in methanol and settled into diethyl ether to obtain 82.7 g of hyperbranched polyarginine.

Embodiment 2

[0064] Add 91.32 grams of lysine hydrochloride and 28.05 grams of KOH to a 500 mL round-bottomed flask, connect a water separator, and replace nitrogen three times for more than 10 minutes each time. Finally, keep a nitrogen atmosphere and stir and heat for 1 minute at 250 °C. , the heating was stopped, the polymer was dissolved in methanol and settled into ether to obtain 84 g of hyperbranched polylysine.

[0065] The H NMR spectra of the synthesized branched polyamino acids are as follows: figure 1 shown.

Embodiment 3

[0067] Add 50 g of serine and 50 mL of n-hexanol into a 500 mL round-bottomed flask, connect to a water separator, and under a nitrogen atmosphere, stir and heat for 10 h at 190 °C, stop heating, and then cool the reaction system to room temperature. Dissolve and settle into ether to obtain 28.5 g of hyperbranched polyserine.

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Abstract

The invention provides a branched polyamino acid bacteriostat. The branched polyamino acid bacteriostat comprises branched polyamino acid and is prepared by homopolymerizing one amino acid unit, wherein the amino acid unit has a structure shown as a formula I. The raw material used by the invention is amino acid and is a natural biomaterial; the branched polyamino acid bacteriostat has no toxic and / or side effects, is a green and environment-friendly novel bacteriostat and is easily accepted by a user; with a branched structure of the polyamino acid, the substance has multiple active functional groups and good biocompatibility, and can be further modified. In addition, the bacteriostat can tear a bacterial membrane to cause the death of bacteria and can prevent drug resistance after beingused for a long term.

Description

technical field [0001] The invention relates to the technical field of bacteriostatic agents, in particular to a branched polyamino acid bacteriostatic agent and its application. Background technique [0002] The invention of antibiotics has saved hundreds of millions of lives and spared human beings from the suffering of bacterial infections, which can be said to be a revolution in medicine. However, with the abuse of small-molecule antibiotics, coupled with the short life cycle of bacteria and the characteristics of horizontal gene transfer, various drug-resistant bacteria have emerged. The spread of pathogenic bacteria is a serious threat to people's normal life. If left unchecked, superbugs could kill an estimated 10 million people a year by 2050, according to a new study. Drug-resistant bacteria have become a hot issue of common concern around the world, which is related to global human health, economic development and social stability. [0003] Compared with small-m...

Claims

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Application Information

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IPC IPC(8): C08G69/10C08G69/16C08G69/48A01N37/46A01N47/44A61K31/785A61K31/787A01P1/00A01P3/00A61P31/04A61P31/10A61K8/88A61Q19/00A23L3/3526A23L3/3535A23L3/3544
CPCA01N37/46A01N47/44A23L3/3526A23L3/3535A23L3/3544A61K8/88A61K31/785A61K31/787A61K2800/10A61K2800/524A61Q19/00C08G69/10C08G69/16C08G69/48
Inventor 季生象刘骁韩苗苗刘亚栋郭建伟
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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