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Levofloxacin hydrochloride capsules and preparation method thereof

A technology of levofloxacin hydrochloride and capsules, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of unsatisfactory drug dissolution speed and inability to exert drug effects quickly, and achieve anti-adhesion and help. Good fluidity, improved bioavailability and improved particle hardness

Inactive Publication Date: 2018-06-15
安徽新世纪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a levofloxacin hydrochloride capsule and its preparation method, to solve the problem that the drug dissolution rate of the levofloxacin hydrochloride capsule is not ideal, and then the drug effect cannot be brought into play quickly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A levofloxacin hydrochloride capsule, the components and parts by weight of the capsule include: 25 parts of levofloxacin hydrochloride, 26 parts of starch, 10 parts of dextrin, 4 parts of lactose, 6 parts of low-substituted hydroxypropyl cellulose, and 3 parts of polyethylene glycol , 1 part polysorbate 80, 1 part crospovidone, 2 parts magnesium stearate, 4 parts talc, 1 part high melting point wax.

[0022] A preparation method of levofloxacin hydrochloride capsules, specifically comprising the following steps:

[0023] 1). Sieve starch, dextrin, lactose, low-substituted hydroxypropyl cellulose, polyethylene glycol, polysorbate 80, crospovidone, magnesium stearate, talcum powder and high melting point wax, and carry out Fully mix to obtain the mixed material, and then pass the mixed material through an 80-mesh sieve;

[0024] 2). Grinding levofloxacin hydrochloride through a 90-mesh sieve;

[0025] 3). Fully mix the mixed material obtained in step 1) with the levofl...

Embodiment 2

[0029] A levofloxacin hydrochloride capsule, the components and parts by weight of the capsule include: 88 parts of levofloxacin hydrochloride, 48 parts of starch, 20 parts of dextrin, 8 parts of lactose, 12 parts of low-substituted hydroxypropyl cellulose, and 4 parts of polyethylene glycol , 2 parts of sodium lauryl sulfate, 2 parts of crospovidone, 4 parts of magnesium stearate, 5 parts of talc, 2 parts of high melting point wax.

[0030] A preparation method of levofloxacin hydrochloride capsules, specifically comprising the following steps:

[0031] 1). Sieve starch, dextrin, lactose, low-substituted hydroxypropyl cellulose, polyethylene glycol, surfactant, crospovidone, magnesium stearate, talcum powder and high melting point wax, and fully Mix to obtain the mixed material, then pass the mixed material through an 80-mesh sieve;

[0032] 2). Grinding levofloxacin hydrochloride through a 90-mesh sieve;

[0033] 3). Fully mix the mixed material obtained in the step 1) wit...

Embodiment 3

[0037] A levofloxacin hydrochloride capsule, the components and parts by weight of the capsule include: 56.5 parts of levofloxacin hydrochloride, 37 parts of starch, 15 parts of dextrin, 6 parts of lactose, 9 parts of low-substituted hydroxypropyl cellulose, and 3.5 parts of polyethylene glycol , 0.5 parts of polysorbate 80, 1 part of sodium lauryl sulfate, 1.5 parts of crospovidone, 3 parts of magnesium stearate, 4.5 parts of talc, 1.5 parts of high melting point wax.

[0038] A preparation method of levofloxacin hydrochloride capsules, specifically comprising the following steps:

[0039] 1). Sieve starch, dextrin, lactose, low-substituted hydroxypropyl cellulose, polyethylene glycol, surfactant, crospovidone, magnesium stearate, talcum powder and high melting point wax, and fully Mix to obtain the mixed material, then pass the mixed material through an 80-mesh sieve;

[0040] 2). Grinding levofloxacin hydrochloride through a 90-mesh sieve;

[0041] 3). Fully mix the mixed...

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PUM

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Abstract

The invention discloses levofloxacin hydrochloride capsules and a preparation method thereof. The levofloxacin hydrochloride capsules are prepared from, by weight, 25-88 parts of levofloxacin hydrochloride, 26-48 parts of starch, 10-20 parts of dextrin, 4-8 parts of lactose, 6-12 parts of low-substituted hydroxypropyl cellulose, 3-4 parts of polyethylene glycol, 1-2 parts of surface active agent,1-2 parts of polyvinylpolypyrrolidone, 2-4 parts of magnesium stearate, 4-5 parts of talcum powder, and 1-2 parts of high-melting-point wax. According to the capsules, the low-substituted hydroxypropyl cellulose, the surface active agent, and the polyvinylpolypyrrolidone are selected to serve as disintegrating agents, the magnesium stearate, the talcum powder, and the high-melting-point wax serveas lubricating agents, and the complementary cooperative effects among them enable fast disintegration of particles in the capsules and enable medicine dissolution, so that the capsules take effect quickly, and the time for patients to suffer pain is shortened; the combined disintegrating agents and lubricating agents also have a good effect in the capsules and enable fast medicine dissolution; inaddition, the manufacturing process is simple, the cost is reduced, and the capsules are suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to a levofloxacin hydrochloride capsule and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride is the left-handed body of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. . It has the characteristics of broad antibacterial spectrum and strong antibacterial effect. For most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter and Pseudomonas aeruginosa Gram-negative bacteria such as Monas, Haemophilus influenzae, and Neisseria gonorrhoeae have strong antibacterial activity. It also has a good antibacterial effect on Gram-positive bacteria such as methicillin-sensitive Staphylococcus, Strepto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/5383A61K47/38A61K47/32A61K47/12A61K47/02A61K47/44A61K47/20A61K47/26A61P31/04
CPCA61K9/1611A61K9/1617A61K9/1635A61K9/1641A61K9/1652A61K31/5383
Inventor 周月韦勇冯书影申团结
Owner 安徽新世纪药业有限公司
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