Application of cinchonain Ib to preparation of medicament for preventing and treating rheumatoid arthritis

A technology for rheumatoid and arthritis, which is applied in the application field of cinchonine Ib in the preparation of drugs for the prevention and treatment of rheumatoid arthritis, and can solve the problems of toxic side effects affecting patient compliance, high price, and difficulty in popularization
CN108210491AInactive Publication Date: 2018-06-29天津华泰至成医药科技发展有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
天津华泰至成医药科技发展有限公司
Publication Date
2018-06-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of cinchonain Ib to preparation of a medicament for preventing and treating rheumatoid arthritis and a healthy food for preventing rheumatoid arthritis. Experimentsshow that the cinchonain Ib can significantly inhibit the auricle swelling of mice caused by xylene and effectively relieve foot swelling of rats caused by carrageenin. An acetic acid abdominal constriction test and a hot plate test show that the cinchonain Ib has a certain analgesic effect, and the acting effect becomes more remarkable along with the acting time. Moreover, the cinchonain Ib hasa good antagonistic effect on primary plantar swelling induced by adjuvants, which indicates that the cinchonain Ib is to have a very good application prospect in the prevention and treatment of rheumatoid arthritis.
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Description

technical field

[0001] The invention relates to the application of cinchonaine Ib in the preparation of drugs for preventing and treating rheumatoid arthritis. Background technique

[0002] Flavonoid lignans are a new class of flavonoids with C-9 substituents, that is, compounds formed by condensation of flavonoids and phenylpropanoid derivatives. Tumor, bactericidal and other biological activities [1] . Cinchonaine Ib is a flavonoid lignan compound, which is derived from the genus Brasilia of Meliaceae, the genus Panax notoginseng in the family Polygonaceae, the genus Panax notoginseng in the family Polygonaceae, the genus Margarita genus in the family Primulaceae, the genus P. The roots, stems, fruits and seeds of plants belonging to 6 families and 8 genera, including the genus Red Sea Lavender, the genus Candela, the genus Smilax in the family Liliaceae, the genus Smilax in the family Rosaceae, the genus Loquat and the genus Apple, are used as raw materials. Current st...

Claims

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