A bone graft composite material for alveolar bone augmentation

Abstract

The invention belongs to the technical field of medical treatment, and particularly relates to a bone grafting composite material for alveolar bone augmentation. The bone grafting composite material for alveolar bone augmentation is characterized by being divided into three layers in sequence from interior to exterior, which are an autogenous bone, a support material and a CPC / PLGA compound; the volume ratio of the autogenous bone to the support material is 1:1. The composite material combines application of the autogenous bone, the inorganic element support material, the CPC / PLGA compound andautoblood, on the basis of characteristics of autogenous bone generation and bone induction and the advantages of plasticity, biodegradability and self-solidification-strength of the CPC / PLGA compound, autoblood provides abundant growth factors for bone repair, the bone grafting composite material is ideal, bone regeneration is guided, bone formation is promoted, and the alveolar bone amount is increased.

Description

technical field [0001] The invention belongs to the field of medical technology, in particular to a bone graft composite material used for alveolar bone augmentation. Background technique [0002] Alveolar bone atrophy after tooth extraction is a common clinical problem in stomatology, which seriously hinders the restoration of oral function in patients. Horizontal or vertical bone augmentation surgery is usually required to provide sufficient bone for later implant restoration. Among them, the vertical bone augmentation technique is difficult, and the common vertical bone augmentation techniques in clinical practice include guided bone regeneration (GBR), distraction osteogenesis (DO), and Onlay bone grafting. [0003] (1) Guided bone regeneration (GBR) is a technique in which a bone substitute or the patient's own bone is implanted into the bone defect area around the implant, and then covered and fixed on the surface with a barrier membrane. The barrier membrane acts as ...

AI Technical Summary

Problems solved by technology

Common nonabsorbable barrier membranes in clinical practice include titanium mesh, expanded polytetrafluoroethylene (e-PTFE) membrane, etc. The nonabsorbable barrier membrane has strong supporting force and can provide a relatively stable submembrane space , not easy to collapse, can prevent epithelial and fiber ingrowth, the disadvantage is that the texture is too hard and easy to cause mucosal rupture, wound exposure leads to treatment failure

And because of its non-absorbable nature, a second surgery is required to remove it

[0005] Absorbable membranes are divided into non-linked collagen membranes and cross-linked collagen membranes, among which non-linked collagen membranes are the most widely used clinically, which avoids the defects of secondary operations of non-absorbable membranes. However, collagen membranes have poor support, especially in When repairing vertical bone defects, bone augmentation surgery often fails due to insufficient space for bone growth

[0006] Disadvantages of guided bone regeneration (GBR) technology: (1) non-absorbable membrane: the disadvantage is that the texture is too hard, which can easily lead to mucosal rupture, and wound exposure leads to treatment failure

The treatment period is long, the stretcher can cause discomfort to the patient, affect the daily pronunciation and aesthetics, the oral hygiene is not easy to maintain, which can lead to infection, and the movement of the bone must be detected frequently during the stretching period

[0008] Disadvantages of Distraction Osteogenesis (DO): long treatment cycle, severe discomfort for patients, poor oral hygiene, which may lead to infection

[0010] The disadvantages of Onlay autologous bone grafting technique: (1) The need to open up a second surgical area requires large trauma and limited bone volume; (2) There is a lot of postoperative autologous bone resorption, and the effect on vertical bone augmentation is not good