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Silicon-containing grain boundary phase modified hydroxyapatite ceramic, bone injury repair material and preparation method of hydroxyapatite ceramic

A hydroxyapatite and silicon crystal technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of rapid degradation and ion dissolution, loose material structure, poor material uniformity, etc., to promote proliferation and osteogenic differentiation. , the effect of improving osteogenic performance

Active Publication Date: 2018-08-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the uniformity of the material in the direct mechanical mixing method is poor. The silicon-containing material modified hydroxyapatite ceramics prepared by the direct mechanical mixing method cannot form a uniform and tight bond between the two phases, resulting in a loose material structure. Significantly lower mechanical properties
At the same time, the inhomogeneous and loose structure makes the degradation of the material and the dissolution of ions faster, causing the pH of the local environment to be too high, which has an adverse effect on the bone repair effect

Method used

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  • Silicon-containing grain boundary phase modified hydroxyapatite ceramic, bone injury repair material and preparation method of hydroxyapatite ceramic
  • Silicon-containing grain boundary phase modified hydroxyapatite ceramic, bone injury repair material and preparation method of hydroxyapatite ceramic
  • Silicon-containing grain boundary phase modified hydroxyapatite ceramic, bone injury repair material and preparation method of hydroxyapatite ceramic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Dissolve tetraethyl silicate in deionized water to obtain a silicon-containing solution, the molar ratio of the tetraethyl silicate to the deionized water is 1:8, the amount of tetraethyl silicate is 67.20ml, and the deionized water The dosage is 43.2ml, use 1mol / L dilute nitric acid solution to adjust the pH value of the silicon-containing solution to 1.5, and stir with a stirrer at a speed of 350r / min for 45min;

[0039] Add triethyl phosphate (TEP, OP (OC 2 h 5 ) 3 ), stirred with a mixer for 45min at a speed of 350r / min;

[0040] Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 0), stir 45min with the speed of 350r / min with agitator, after the solution is clarified, obtain silicon-containing mixed sol, contain SiO in the silicon-containing mixed sol 2 : 60mol%, CaO: 36mol%, P 2 o 5 : 4mol%;

[0041] The molar ratio of tetraethyl silicate, calcium nitrate tetrahydrate and triethyl phosphate is 60:36:8, and the specific dosages are 67.20ml, 42.51g and 6.81ml re...

Embodiment 2

[0058] Dissolve tetramethyl silicate in deionized water to obtain a silicon-containing solution, the molar ratio of the tetramethyl silicate to the deionized water is 1:1, the amount of tetramethyl silicate is 29.76ml, and the deionized water The dosage is 3.6ml, use 1mol / L dilute lactic acid solution to adjust the pH value of the silicon-containing solution to 1.0, and stir with a mixer at a speed of 600r / min for 15min;

[0059] Add triethyl phosphate (TEP, OP (OC 2 h 5 ) 3 ), stirred with a mixer for 15min at a speed of 600r / min;

[0060] Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 0), stir 15min with the speed of 600r / min with the stirrer, after the solution is clarified, obtain silicon-containing mixed sol, silicon-containing mixed sol contains SiO 2 , 40mol%; CaO, 56mol%; P 2 o 5 , 4mol%;

[0061] The molar ratio of tetramethyl silicate, calcium nitrate tetrahydrate and triethyl phosphate is 40:56:8, and the specific dosages are 29.76ml, 66.12g and 6.81ml resp...

Embodiment 3

[0076]Dissolve tetramethyl silicate in deionized water to obtain a silicon-containing solution, the molar ratio of tetramethyl silicate to deionized water is 1:6, the amount of tetramethyl silicate is 59.52ml, deionized The amount of water used is 43.20ml, use 1mol / L dilute acetic acid solution to adjust the pH value of the silicon-containing solution to 2.0, and stir with a mixer at a speed of 300r / min for 40min;

[0077] Add triethyl phosphate (TEP, OP (OC 2 h 5 ) 3 ), stirred with a mixer for 40min at a speed of 300r / min;

[0078] Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 (2), stir 40min with a stirrer at a speed of 300r / min, and after the solution is clarified, obtain a silicon-containing mixed sol, which contains SiO 2 , 80mol%; CaO, 19mol%; P 2 o 5 , 1mol%;

[0079] The molar ratio of tetramethyl silicate, calcium nitrate tetrahydrate and triethyl phosphate is 80:19:2, and the specific dosages are 59.52ml, 22.43g and 1.70ml respectively.

[0080] Fill 0.2g...

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Abstract

The invention belongs to the field of medical materials for bone injury repair and discloses silicon-containing grain boundary phase modified hydroxyapatite ceramic, a bone injury repair material anda preparation method of the hydroxyapatite ceramic. The method comprises the steps as follows: firstly, a silicon source, triethyl phosphate and calcium nitrate tetrahydrate fully react in the ratio to produce silicon-containing mixed sol, then, a pre-sintered hydroxyapatite body is impregnated and permeated with the silicon-containing mixed solution under the vacuum negative-pressure condition, drying and high-temperature sintering are performed, and the silicon-containing grain boundary phase modified hydroxyapatite ceramic is obtained. According to the silicon-containing grain boundary phase modified hydroxyapatite ceramic prepared with a sol permeation method, a silicon-containing grain boundary phase formed during sintering coats hydroxyapatite grains, and combination of hydroxyapatite grains is improved, so that the material has good mechanical performance. The silicon-containing grain boundary phase introduces silicon elements for the hydroxyapatite ceramic, the degradation property of hydroxyapatite is improved, and the osteogenesis performance of the material is improved.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to silicon-containing grain boundary phase-modified hydroxyapatite ceramics, bone damage repairing materials and a preparation method thereof. Background technique [0002] Hydroxyapatite is a calcium phosphate bone repair material that has been widely studied and used. Its composition is similar to the inorganic mineral composition of human bones and teeth, has good biocompatibility, and can bond with bone tissue after implantation in the body. However, hydroxyapatite is the most stable calcium phosphate material, and it hardly biodegrades under the pH value and temperature environment in the organism. Therefore, the biological reaction between hydroxyapatite and tissues is relatively slow, and bone formation The ability is low, which affects the effect of bone repair. [0003] Silicon exists in bone and connective tissue in the body and can ...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622C04B35/64C04B35/16A61L27/12A61L27/10A61L27/58
CPCA61L27/10A61L27/12A61L27/58A61L2430/02C04B35/16C04B35/447C04B35/622C04B35/64
Inventor 叶建东徐玉彬陆特良
Owner SOUTH CHINA UNIV OF TECH
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